Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar, Ramin Yousefpour; Fakhr, Zahra Ahmadi; Abbasgholinejad, Elham; Doroudian, Mohammad

doi:10.1002/adtp.202300275

Cited by 4 publications

(3 citation statements)

References 240 publications

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“…Furthermore, a diverse array of nanomaterials is already being used to overcome the limitations of lung therapies. The substantial absorption, extensive circulation, and permeability of the lungs promote nanoparticles (NPs) accumulation in the airways and lungs [ 49 ]. These unique characteristics make nanomaterials potential tools for lung therapy.…”

Section: Nano-delivery System For Pulmonary Diseases Treatmentmentioning

confidence: 99%

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases

Lei,

Pan,

Shou

et al. 2024

J Nanobiotechnol

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The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This review discusses the utilization of nanomaterial-assisted gene editing tools and synthetic biology techniques to promote the development of more precise and efficient treatments for pulmonary diseases. First, we briefly outline the characterization of the respiratory system and succinctly describe the principal applications of diverse nanomaterials in lung ailment treatment. Second, we elaborate on gene-editing tools, their configurations, and assorted delivery methods, while delving into the present state of nanomaterial-facilitated gene-editing interventions for a spectrum of pulmonary diseases. Subsequently, we briefly expound on synthetic biology and its deployment in biomedicine, focusing on research advances in the diagnosis and treatment of pulmonary conditions against the backdrop of the coronavirus disease 2019 pandemic. Finally, we summarize the extant lacunae in current research and delineate prospects for advancement in this domain. This holistic approach augments the development of pioneering solutions in lung disease treatment, thereby endowing patients with more efficacious and personalized therapeutic alternatives.

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Section: Nano-delivery System For Pulmonary Diseases Treatmentmentioning

confidence: 99%

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases

Lei,

Pan,

Shou

et al. 2024

J Nanobiotechnol

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“…Solid-lipid nanoparticles are the best nano-carrier system for targeted drug administration because they combine the qualities of polymeric nanoparticles, liposomes, and fat emulsion carriers [46,47].…”

Section: [4] Polymeric Micellesmentioning

confidence: 99%

Developments in Nanotechnology for Lung Cancer Treatment: A Comprehensive Strategy

Khera,

Singh,

Deopa

2024

Int. J. Res. Publ. Rev.

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Lung cancer is a significant worldwide health concern that demands novel approaches to its management. The field of nanotechnology has shown great promise for revolutionizing the treatment of this illness. An overview of the many applications of nanotechnology in lung cancer treatment is given in this abstract. For the treatment of lung cancer, drug delivery has been transformed using nanotechnology. Chemotherapy medicines can be specifically and precisely released at the tumor location by using nanoparticles that have been designed to encapsulate them. Patients receiving treatment benefit from this focused approach's dual benefits of minimizing systemic toxicity and increasing therapeutic effect, all of which improve patient quality of life. Furthermore, a major obstacle in the treatment of lung cancer is drug resistance, which nanoparticles help to overcome. The role of important receptors as well as the targeting types have also been discussed.Nanotechnology provides fresh ways to counter resistance mechanisms and boost treatment regimen efficacy through the creation of creative medication formulations and combination therapies.

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“…Cancer, as stated by the World Health Organization (WHO), stands as a leading cause of mortality worldwide [1]. Specifically, lung cancer is among the most reported cancerrelated deaths globally [2,3], constituting 11.6% of new cancer diagnoses and accounting for 19.8% of cancer-related fatalities [4,5].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment

Rahimian,

Najafi,

Afzali

et al. 2024

Biomedicines

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Lung cancer demands innovative approaches for early detection and targeted treatment. In addressing this urgent need, exosomes play a pivotal role in revolutionizing both the early detection and targeted treatment of lung cancer. Their remarkable capacity to encapsulate a diverse range of biomolecules, traverse biological barriers, and be engineered with specific targeting molecules makes them highly promising for both diagnostic markers and precise drug delivery to cancer cells. Furthermore, an in-depth analysis of exosomal content and biogenesis offers crucial insights into the molecular profile of lung tumors. This knowledge holds significant potential for the development of targeted therapies and innovative diagnostic strategies for cancer. Despite notable progress in this field, challenges in standardization and cargo loading persist. Collaborative research efforts are imperative to maximize the potential of exosomes and advance the field of precision medicine for the benefit of lung cancer patients.

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Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Cited by 4 publications

References 240 publications

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases

Developments in Nanotechnology for Lung Cancer Treatment: A Comprehensive Strategy

Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment

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