Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment

Rahimian, Sana; Najafi, Hossein; Afzali, Baran; Doroudian, Mohammad

doi:10.3390/biomedicines12010123

Cited by 6 publications

(3 citation statements)

References 165 publications

(211 reference statements)

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“…These nano-sized vesicles are secreted by a variety of cell types and have the unique ability to encapsulate a variety of biomolecules, cross biological barriers, and are designed to target specific molecules. This makes them very promising for the development of diagnostic markers and precise drug delivery systems for cancer cells ( 87 ). Lung cancer, especially at advanced stages, often poses significant challenges for effective treatment.…”

Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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BackgroundLung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of its pathogenesis and discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting tumor growth, and metastasis through the release of exosomes. Exosomes are small vesicles secreted by cells and contain a variety of bioactive molecules such as proteins, nucleic acids, and metabolites. This paper presents a comprehensive review of exosome research in lung cancer and its progress through bibliometric analysis.MethodsPublications related to exosomes in lung cancer patients were systematically searched on the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviwers, CiteSpace, and the R package “Bibliometrics”. Publications were quantitatively analyzed using Microsoft Office Excel 2019. The language of publication was restricted to “English” and the search strategy employed TS=(exosomes or exosomes or exosomes) and TS=(lung cancer). The search period commenced on January 1, 2004, and concluded on November 12, 2023, at noon. The selected literature types included Articles and Reviews.ResultsThe study encompassed 1699 papers from 521 journals across 71 countries and 2105 institutions. Analysis revealed a consistent upward trend in lung cancer exosome research over the years, with a notable surge in recent times. This surge indicates a growing interest and depth of inquiry into lung cancer exosomes. Major research institutions in China and the United States, including Nanjing Medical University, Shanghai Jiao Tong University, Chinese Academy Of Sciences, and Utmd Anderson Cancer Center, emerged as crucial research hubs. The annual publication count in this field witnessed a continuous rise, particularly in recent years. Key terms such as lung cancer, non-small cell lung cancer (NSCLC), microvesicles, intercellular communication, exosomal miRNAs, and oncology dominated the research landscape. Fields like cell biology, biochemistry, biotechnology, and oncology exhibited close relation with this research. Clotilde Théry emerged as the most cited author in the field, underlining her significant contributions. These results demonstrate the broad impact of exosome research in lung cancer, with key terms covering not only disease-specific aspects such as lung cancer and NSCLC but also basic biological concepts like microvesicles and intercellular communication. Explorations into exosomal microRNAs and oncology have opened new avenues for lung cancer exosome research. In summary, lung cancer exosome research is poised to continue receiving attention, potentially leading to breakthroughs in treatment and prevention.ConclusionPublications on lung cancer exosomes show a rising trend year by year, with China and the United States ranking first and second in terms of the number of publications. However, there is insufficient academic learning cooperation and exchanges between the two sides, and Chinese universities account for a large proportion of research institutions in this field. Jing Li is the most productive author, Clotilde Théry is the most co-cited author, and Cancers is the journal with the highest number of publications. The current focus in the field of lung cancer exosomes is on biomarkers, liquid biopsies, immunotherapy, and tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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“…HEK293T-derived EVs loaded with Wnt protein can induce epithelial cell regeneration in a murine model of emphysema [ 19 ]. Extracellular vesicles derived from various cell types carrying chemotherapeutics, miRNAs, or tumor antigens are already being developed and have shown efficacy against lung cancer [ 20 ]. Specific testing of these delivery methods with additional types of extracellular vesicles is needed to determine if the efficacy is similar to that of platelet-derived exosomes.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Biodistribution of Platelet-Derived Regenerative Exosomes in a Porcine Model

Rizzo,

Bagwell,

Schiebel

et al. 2024

IJMS

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The purpose of this study was to evaluate the biodistribution of a platelet-derived exosome product (PEP), previously shown to promote regeneration in the setting of wound healing, in a porcine model delivered through various approaches. Exosomes were labeled with DiR far-red lipophilic dye to track and quantify exosomes in tissue, following delivery via intravenous, pulmonary artery balloon catheter, or nebulization in sus scrofa domestic pigs. Following euthanasia, far-red dye was detected by Xenogen IVUS imaging, while exosomal protein CD63 was detected by Western blot and immunohistochemistry. Nebulization and intravenous delivery both resulted in global uptake of exosomes within the lung parenchyma. However, nebulization resulted in the greatest degree of exosome uptake. Pulmonary artery balloon catheter-guided delivery provided the further ability to localize pulmonary delivery. No off-target absorption was noted in the heart, spleen, or kidney. However, the liver demonstrated uptake primarily in nebulization-treated animals. Nebulization also resulted in uptake in the trachea, without significant absorption in the esophagus. Overall, this study demonstrated the feasibility of pulmonary delivery of exosomes using nebulization or intravenous infusion to accomplish global delivery or pulmonary artery balloon catheter-guided delivery for localized delivery.

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“…In addition to nanomaterials, extracellular vesicles are frequently used to encapsulate and deliver diverse biological substances, including microRNAs (miRNAs), mRNAs, and proteins [ 120 , 121 ]. These vesicles exhibit a double-membrane structure with diameters ranging from 40 nm to 1,000 nm [ 122 ].…”

Section: Nano-delivery System For Pulmonary Diseases Treatmentmentioning

confidence: 99%

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases

Lei,

Pan,

Shou

et al. 2024

J Nanobiotechnol

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The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This review discusses the utilization of nanomaterial-assisted gene editing tools and synthetic biology techniques to promote the development of more precise and efficient treatments for pulmonary diseases. First, we briefly outline the characterization of the respiratory system and succinctly describe the principal applications of diverse nanomaterials in lung ailment treatment. Second, we elaborate on gene-editing tools, their configurations, and assorted delivery methods, while delving into the present state of nanomaterial-facilitated gene-editing interventions for a spectrum of pulmonary diseases. Subsequently, we briefly expound on synthetic biology and its deployment in biomedicine, focusing on research advances in the diagnosis and treatment of pulmonary conditions against the backdrop of the coronavirus disease 2019 pandemic. Finally, we summarize the extant lacunae in current research and delineate prospects for advancement in this domain. This holistic approach augments the development of pioneering solutions in lung disease treatment, thereby endowing patients with more efficacious and personalized therapeutic alternatives.

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Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment

Cited by 6 publications

References 165 publications

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Pulmonary Biodistribution of Platelet-Derived Regenerative Exosomes in a Porcine Model

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases

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