Pulmonary Biodistribution of Platelet-Derived Regenerative Exosomes in a Porcine Model
Skylar A. Rizzo,
Monique S. Bagwell,
Paige Schiebel
et al.
Abstract:The purpose of this study was to evaluate the biodistribution of a platelet-derived exosome product (PEP), previously shown to promote regeneration in the setting of wound healing, in a porcine model delivered through various approaches. Exosomes were labeled with DiR far-red lipophilic dye to track and quantify exosomes in tissue, following delivery via intravenous, pulmonary artery balloon catheter, or nebulization in sus scrofa domestic pigs. Following euthanasia, far-red dye was detected by Xenogen IVUS im… Show more
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