Treatment intensity and characteristics of MRSA infection in CF

Muhlebach, Marianne S.; Miller, Meredith; LaVange, Lisa M.; Mayhew, Gregory M.; Goodrich, Jennifer S.; Miller, Melissa B.

doi:10.1016/j.jcf.2011.02.004

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…[27][28][29] Furthermore, older patients with CF are more likely to harbor hospitalassociated clones, suggesting acquisition prior to the widespread onset of CA MRSA. 30 Support for acquisition of MRSA in health-care settings is provided by a report that found that more stringent infection prevention and control strategies, which included universal contact precautions, significantly reduced MRSA in a pediatric CF clinic. 31 Studies to find effective therapeutic approaches to eradication are ongoing.…”

Section: Discussionmentioning

confidence: 99%

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

Salsgiver

Fink

Knapp

et al. 2016

Chest

199

166

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Section: Discussionmentioning

confidence: 99%

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

Salsgiver

Fink

Knapp

et al. 2016

Chest

199

166

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“…FEV 1 percent predicted did not differ among patients colonized with MRSA or with MSSA, even after adjusting for Pseudomonas colonization, age, and gender. While MRSA patients did require more pulmonary maintenance therapy (i.e., mucolytics, inhaled steroids, and chronic antimicrobial suppressive therapy), they did not require a greater number of antibiotic courses than did MSSA patients (65). In another cohort, MRSA-colonized patients had a faster decline in lung function even before acquisition of MRSA, suggesting that MRSA was not the cause of this decline but may have been a proxy marker (66).…”

Section: Cystic Fibrosis (Cf) Mrsa Carriage and Disease Progressionmentioning

confidence: 92%

Update on Epidemiology and Treatment of MRSA Infections in Children

David

Daum

2013

Curr Pediatr Rep

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In 2000-10 the epidemiology of pediatric MRSA infections in the United States was transformed with an epidemic of CA-MRSA infections. We review the epidemiology of MRSA in the community and in the health care setting, including intensive care units, among infants and CF patients, and in households as well as the impact that the CA-MRSA epidemic has had on hospitalization with MRSA infections. Risk factors for carriage, transmission, and initial and recurrent infection with MRSA are discussed. New studies on the treatment of pediatric MRSA infections and on the efficacy of MRSA decolonization are reviewed.

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“…219 The latter group consisted of younger individuals. In a multicenter study conducted in the United States from 2008 to 2010, SCCmec type II strains were more common than SCCmec type IV strains, accounting for 71% of MRSA isolates, and 84% of SCCmec type IV strains that harbored Panton-Valentine leukocidin were USA300, the most common community-associated MRSA clone.…”

Section: Iiia3 Other Gram-negative Bacteriamentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

344

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Treatment intensity and characteristics of MRSA infection in CF

Abstract: Patients with chronic MRSA are treated more intensely than age, gender and Pseudomonas aeruginosa matched MSSA-positive patients but clinical characteristics within MRSA patients vary depending on MRSA types.

Cited by 34 publications

References 29 publications

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

Update on Epidemiology and Treatment of MRSA Infections in Children

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

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