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Patients with chronic MRSA are treated more intensely than age, gender and Pseudomonas aeruginosa matched MSSA-positive patients but clinical characteristics within MRSA patients vary depending on MRSA types.

SummaryBtrc,/qrorrrid: Elevation of acute phase proteins [C-reactive protein (CRP) and serum amyloid type A (SAA)I has been denionstrated in unstable angina with an adverse clinical prognosis.H\porlie.sis: The study was undertalien to detetinine the effect of angioplasty on the levels of SAA arid the cotIelation with postangioplasty restenosis.Mcthods: In a university-aftiliated tertiary niedical center, a prospective case study was undertaken in 55 patients who underwent successful percutaneous transluininal coronary angioplasty (PTCA) of a single coronary lesion for angina pectotis. Three groups of patients were clinically characterized according to Braunwaltl's classification of anginal syndrome:111; Group B: class I; Group C: stable angina. Serum amyloid type A was measured by an ELlSA method bef'ore PTCA and after 24 h, I , and 3 months. Patients were followed clinically for 12 months. A thallium stress perfusion sciin was performed 3 months after PTCA and coronary angiography was repeated in patients with an abnortnal thallium petl'usion scan. R(1.sirlt.v: Serum aniyluid type A levels > I 0 0 p g h l could identify Group A patients with a high sensitivity and specificity ( I = 0.85 and 0.86. respectively). Of the patients studied. 75'4 increased their SAA level 24 h at'ter angioplasty. An increiisc of SAA by >100% was associated with an increased risk ofrestenosis, with ii relative risk of6.4 (p < 0.05).Co/ichaiori: Increased levels of SAA charactetix patients with unstable anginapectoris with a high specificity aiid sensitivity. Levels of SAA that increase > loOc% 24 h after angiopla.\ly may serve as a marker ofrestenosis.

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types were calculated by comparing results to the patient infected status (PIS) algorithm of wet mount and TV culture. Results Results from 838 participants were available for evaluation. The overall prevalence of TV in this population was 120/838 (14.3%). Using the self-collected vaginal swab as the reference comparator, there was excellent agreement between vaginal swabs, neat and UPT urine, and endocervical swabs (kappa 0.93-0.95). Of these specimen types, endocervical had the lowest yield but still had excellent agreement with vaginal specimens. Conclusions Vaginal, urine, and endocervical samples showed excellent agreement for diagnosis of TV and are all acceptable specimens for use with the BD Viper™ System in extracted mode. The development of NAATS testing for TV, especially with the potential use of self-collected vaginal swab and urine specimens should greatly facilitate screening for this common STI. Background Trichomonas vaginalis (TV) is a sexually transmitted organism associated with vaginitis, cervicitis, urethritis, low birth weight, preterm delivery, pelvic inflammatory disease and HIV transmission and acquisition. Nucleic acid amplification testing improves the sensitivity for detection of pathogens. The performance of the BD ProbeTec™ TV Q x (TVQ) Amplified DNA Assay and the Gen-Probe Aptima TV assay were compared to patient infected status (PIS) established by the InPouch TV culture and wet mount for the detection of trichomonas in women. Methods Participants with symptoms of trichomonas or presenting for routine visit were enrolled from seven geographically diverse centres. First void urine, a patient collected vaginal swab, and three clinician-collected vaginal swabs were obtained from each participant. Urine was aliquoted into BD neat and UPT tubes as well as an Aptima UTT tube. The first two clinician-collected vaginal swabs were randomised for wet mount and InPouch TV culture. The third was used for the Aptima TV assay. Results There were a total of 1034 compliant participants with evaluable PIS. Specimen and instrument level exclusions resulted in 830 compliant vaginal result sets and 733 neat, UPT and UTT urine result sets for evaluation. For vaginal specimens, the sensitivity (specificity) of the TVQ Assay and the Aptima TV Assay compared to PIS were 98.3% (99%) and 100% (98.3%), respectively. For BD neat and UPT urine specimens, the sensitivity (specificity) of the TVQ Assay compared to PIS were 95.5% (98.7%) and 94.6% (98.6%). For the Aptima UTT urine specimen, the sensitivity and specificity of the Aptima TV Assay compared to PIS were 97.3% and 98.7%. Conclusion The BD ProbeTec™ Trichomonas vaginalis Q x Amplified DNA Assay on the BD Viper™ System in extracted mode demonstrated excellent performance characteristics that were comparable to the only commercially available nucleic acid amplification assay for the detection of Trichomonas vaginalis. Introduction Trichomonas vaginalis (TV) is a protozoan parasite that infects the genitourinary tract of 250 million individuals annually,...