Transungual iontophoresis of lithium and sodium: Effect of pH and co-ion competition on cationic transport numbers

Dutet, Julie; Delgado‐Charro, M. Begoña

doi:10.1016/j.jconrel.2010.02.010

Cited by 16 publications

(2 citation statements)

References 24 publications

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“…SF being more hydrophilic (MW=376.28 Da, logP = -0.67) and present as a single ion in the donor was, a priori, considered a much better candidate for iontophoretic delivery. However, the SF donor solution had a pH ~ 8 to promote the marker ionization state and this could have provided the nail with a negative charge [31][32][33][34], thus SF delivery took place through a cation-selective nail. On the other hand, the NBC donor solution had a pH ~ 3, suggesting a positively charged nail which would be anion-selective.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Iontophoretic and Passive Ungual Penetration by Laser Scanning Confocal Microscopy

Dutet

Delgado‐Charro

2012

Pharm Res

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Section: Discussionmentioning

confidence: 99%

Assessment of Iontophoretic and Passive Ungual Penetration by Laser Scanning Confocal Microscopy

Dutet

Delgado‐Charro

2012

Pharm Res

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“…A linear relationship between increase in cation transport number with its molar fraction as well as with increase in pH (from 4 to 7) was observed. This illustrated that nail cation permselectivity exists at pH 7 [53]. Similarly, Smith et al (2010) studied effect of pH on water uptake, water permeation and transport of ions across the nail plates.…”

Section: Effect Of Phmentioning

confidence: 91%

Transungual delivery: deliberations and creeds

Thatai

Sapra

2014

Intern J of Cosmetic Sci

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SynopsisAlthough considered as trifling illness, nail diseases have a reasonably high occurrence and a noteworthy impact on the patients' quality of life. Furthermore, there is a need to improve the topical treatment for nail diseases to avoid drug interactions and to reduce side effects associated with oral therapy. Topical drug delivery to the nails has established amplified consideration lately. Strategies (such as chemical enhancers, formulation strategies, physical and mechanical methods) are being investigated in order to improve drug permeability across the nail plate. The rationale of this review is to present contemporary information on the structure of human nail along with its comparison with animal hooves. Precincts of nail permeability have been briefly discussed with respect to factors like permeant's molecular size, hydrophilicity, charge and the nature of the vehicle. These factors affect drug uptake and permeation through the nail. Formulations like nail lacquers which mimic cosmetic varnish and colloidal carriers along with nail substitutes that can be utilized for transungual delivery have also been discussed. R esum eBien que consid er e comme etant une maladie insignifiante, les affection des ongles sont relativement fr equentes et ont un impact notable sur la qualit e de vie des patients. En outre, il s'av ere n ecessaire d'am eliorer le traitement topique des maladies des ongles pour eviter les interactions m edicamenteuses et de r eduire les effets secondaires associ es a une th erapie orale. L'administration de m edicaments topiques pour les ongles a rec ßu une consid eration amplifi ee ces derniers temps. Diverses strat egies (activateurs chimiques, des strat egies de formulation, des m ethodes physiques et m ecaniques) sont a l' etude afin d'am eliorer la perm eabilit e de la drogue a travers la plaque de l'ongle. La justification de cette revue est de pr esenter des informations contemporaines sur la structure de l'ongle humain, en la comparant avec les sabots des animaux. Les pr eceptes de perm eabilit e des ongles vontêtre bri evement discut es par rapport a des facteurs comme la taille mol eculaire du perm eant, l'hydrophilie, la charge et la nature du v ehicule, etc. Ces facteurs affectent l'absorption du m edicament et la perm eation a travers l'ongle. Des formulations comme les vernis a ongles qui imitent les vernis cosm etiques et des vecteurs collo€ ıdaux ainsi que les substituts des ongles qui peuventêtre utilis es pour la livraison TU (transungueale) sont egalement examin es.

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Science of the Nail Apparatus

Berker

Baran

2012

Baran &Amp; Dawber's Diseases of the Nails and Their Management

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Transungual iontophoresis of lithium and sodium: Effect of pH and co-ion competition on cationic transport numbers

Cited by 16 publications

References 24 publications

Assessment of Iontophoretic and Passive Ungual Penetration by Laser Scanning Confocal Microscopy

Assessment of Iontophoretic and Passive Ungual Penetration by Laser Scanning Confocal Microscopy

Transungual delivery: deliberations and creeds

Science of the Nail Apparatus

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