Transpupillary thermotherapy (TTT) in circumscribed choroidal hemangioma

Abstract

Our preliminary results suggest that TTT may be used effectively to treat some choroidal hemangiomas in the first instance and prevent fluid leakage provided the lesion does not involve the fovea. However, long-term follow-up and more cases are needed to evaluate the long-term visual outcome and potential risks.

Single spot PDT in patients with circumscribed choroidal haemangioma and near normal visual acuity

“…The tumour becomes symptomatic when leakage leads to a serous detachment involving the fovea, or following a hyperopic shift caused by increasing tumour size within the macula area, in which case visual acuity drops, usually occurring in the 3rd or 4th decade. Several therapies have been advocated, such as argon laser treatment, radiation (external beam, photon irradiation, brachytherapy), and hyperthermia (microwave thermotherapy, transpupillary thermotherapy) [2,3,9,17,20]. However, even initially successful treatment strategies were unable to prevent progressive loss of visual acuity in the long run [16].…”

Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapy

“…If the patient is asymptomatic no treatment is indicated. If the visual acuity drops, usually occurring in the third or fourth decade, several therapies have been advocated, such as argon laser treatment [7,8,18,30], radiation (external beam, photon irradiation, brachytherapy) [12,13,14,19,21,32,41,42], and hyperthermia (microwave thermo therapy, transpupillary thermotherapy) [9,10,11,16,25,28]. In 2000, Barbazetto and Schmidt-Erfurth used photodynamic therapy with verteporfin in two patients [6].…”

Sınırlı ve Difüz Koroid Hemanjiomlarında Tedavi Sonuçlarımız

“…nın 1-2 (ortalama 1,2) seans TTT (300-1100 mW) uyguladığı 10 sınırlı koroid hemanjiomlu olgunun %80'inde subretinal sıvı gerilemiştir. 18 Kliniğimizde daha önce yapılan bir çalışmada ise sınırlı koroid hemanjiomu nedeniyle 1-3 seans TTT (300-1200 mW) uygulanan 38 olgunun (literatür taraması ile elde edilen 28 olgu ve yazar tarafından takip edilen 10 olgu) tamamında subretinal sıvının kaybolduğu, %95'inde ise tümör kalınlığının azaldığı belirtilmiştir. 8 Çalışmamızda TTT uygulanan olguların %64'ünde görme keskinliğinde artış saptanırken, %27'sinde değişiklik olmamıştır.…”