Single spot PDT in patients with circumscribed choroidal haemangioma and near normal visual acuity

Abstract

The present series demonstrates that single spot PDT might be an effective treatment for CCH with a visual acuity > or =20/30, without serious side-effects during a follow-up of at least 18 months.

Photodynamic Therapy Directly Over the Optic Nerve Head to Treat a Papillary Hemangioma

“…Subsequently, a few investigators reported successful use of PDT for choroidal hemangiomas. 9, 10 We treated our patient by placing the spot over the tumor and then directly centered over the optic nerve head. We observed a reduction in the lesion size and also a reduction in the angiographic leakage during follow-up.…”

Photodynamic therapy for choroidal hemangioma

“…In this issue, the same authors have expanded their indications to include patients with slight visual disturbance but with good vision [4]. This is a controversial issue, since some authorities have traditionally believed that this benign vascular tumor should not be treated until it causes visual loss.…”

Photodynamic Therapy for Chorioretinal Diseases: A Practical Approach

“…PDT is considered to be the treatment of choice for choroidal hemangioma, as this treatment modality selectively targets abnormal choroidal vessels without damaging the overlying neurosensory retina. PDT is especially indicated in patients with either evidence of SRF or macular edema [47][48][49][50][51]. When the size of the tumor vessels exceeds the maximum diameter of the spot size that can be used during PDT, multiple treatment spots can be used in one session.…”

“…• 'Standard' protocol: verteporfin is infused over a period of 10 min; PDT treatment is 83 s (standard treatment time) at 600 mW/ cm 2 irradiance, starting exactly 15 min after the start of the verteporfin infusion, compatible with a standard fluence (radiant exposure) of 50 J/m 2 [48]. • 'Bolus' protocol: verteporfin is infused rapidly within 1 min (bolus); PDT treatment is 83 s (standard treatment time) at600 mW/ cm 2 irradiance, starting exactly 6 min after the start of the verteporfin infusion, compatible with a standard fluence (radiant exposure) of 50 J/m 2 [49,50]. ; • 'High fluence' protocol: verteporfin is infused over a period of 10 min; PDT treatment is 166 s (twice the treatment time of the aforementioned protocols) at 600 mW/ cm 2 irradiance, starting exactly 15 min after the start of the verteporfin infusion, compatible with an increased fluence (radiant exposure) of 100 J/m 2 [51].…”

“…3) [52]. The latter two treatment protocols described in aforementioned text appear to have a higher single-treatment longterm success rate in terms of complete resolution of SRF [49][50][51]. The authors of one study reported that the visual outcome of patients with choroidal hemangioma increased from a mean visual acuity of 20/400 in the pre-PDT era to 20/63 in the PDT era [53].…”