Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapy

Verbraak, F. D.; Schlingemann, Reinier O.; Keunen, J. E. E.; Smet, Marc D. de

doi:10.1007/s00417-003-0765-y

Cited by 51 publications

(53 citation statements)

References 37 publications

(74 reference statements)

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“…[46] There have been numerous case series describing patients with circumscribed choroidal hemangioma in which the majority of subjects received one PDT treatment. [46][47][48][49][50][51][52][53][54] In two case series, the vast majority of patients required more than one PDT treatment because the treatment goal was complete resolution of the tumor, not just resolution of subretinal and intraretinal fluid. [50,51] Considering several case series on PDT for choroidal hemangioma, the baseline tumor thickness ranged from 2.6 to 3.8 mm.…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

“…All patients displayed tumor regression to some extent, and 7-100% had complete tumor resolution. [46][47][48][49][50][51][52][53][54] More sessions of PDT may increase the risk of choroidal atrophy and neurosensory retinal degeneration. [51] Visual acuity improvement has been shown to be inversely associated with the number of PDT sessions.…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

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Circumscribed choroidal hemangioma

Mashayekhi

Shields

2003

Current Opinion in Ophthalmology

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Circumscribed choroidal hemangiomas are benign vascular hamartomas without systemic associations. Generally, they are orange-red elevated masses, which are found posterior to the equator. Lesions are usually solitary and unilateral. Overlying subretinal fluid, serous retinal detachment and cystoid macular edema are common findings. Intravenous fluorescein angiography, indocyanine green angiography, ultrasonography, optical coherence tomography and enhanced depth imaging are helpful ancillary tests for diagnosis of circumscribed choroidal hemangiomas. Asymptomatic circumscribed choroidal hemangiomas do not require treatment. For symptomatic lesions with exudative retinal detachment or cystoid macular edema, photodynamic therapy has emerged as the treatment of choice with high rates of tumor regression, subretinal fluid resorption and minimal complications. Lens-sparing external beam radiotherapy, plaque brachytherapy, proton beam therapy, stereotactic radiosurgery, transpupillary thermotherapy, laser photocoagulation and anti-VEGF injections are other treatment modalities.

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Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Circumscribed choroidal hemangioma

Mashayekhi

Shields

2003

Current Opinion in Ophthalmology

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“…Recently, treatment of CCH using photodynamic therapy (PDT) has been reported by several groups with overall favorable outcome [6,7,8,9,10,11,12,13,14]. Based on these reports it is apparent that in comparison to other treatment modalities, PDT has the advantages of a low complication rate, a higher chance of a favorable visual outcome, low risk of recurrence, and lower treatment-associated morbidity.…”

Section: Introductionmentioning

confidence: 99%

Application of the Standard Photodynamic Treatment Protocol for Symptomatic Circumscribed Choroidal Hemangioma

et al. 2006

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Purpose: To describe the results of photodynamic therapy (PDT) using a standard protocol, developed for treating choroidal neovascularization (CNV), for the treatment of circumscribed choroidal hemangioma (CCH). Methods: A prospective, uncontrolled, consecutive case series of patients with symptomatic CCH that were treated using the standard PDT protocol was evaluated periodically with ophthalmic exams and echography. Results: Nine CCH patients were included in the study. Mean tumor height decreased from 2.7 mm before treatment to 0.8 mm at the end of the follow-up period. Mean visual acuity improved from 6/15 to 6/12. Six patients required one PDT session, two patients two sessions, and one patient three sessions. Side effects included transient visual disturbances in two patients. One patient, who concomitantly presented with age-related macular degeneration, developed CNV. Conclusions: The standard PDT protocol is effective for the treatment of CCH. Complications are uncommon. Further studies should assess the optimal PDT protocol for the treatment of CCH.

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“…An improvement in VA was observed in all the cases, in 4 cases VA returned to 20/20, as well as disappearance of subretinal or intraretinal fluid. Verbraak et al [12] described the efficacy of limited, low-irradiance, single-spot PDT for the treatment of symptomatic choroidal hemangiomas in 13 consecutive patients.…”

Section: Photodynamic Therapy Of Ocular Tumorsmentioning

confidence: 99%

Ocular Photodynamic Therapy – Standard Applications and New Indications (Part 2)

et al. 2007

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Photodynamic therapy (PDT) has become a well-established treatment for vascular forms of age-related macular degeneration (AMD). The implementation of evidence-based medicine principles into the treatment regimen of AMD seems to be immensly important, since AMD continues to be the most frequent cause of blindness among patients older than 65 years in industrialized countries. Numerous randomized prospective studies demonstrated high levels of evidence for the efficacy of various treatment approaches such as laser photocoagulation, PDT, subretinal surgery or novel anti-angiogenic drugs [Arch Ophthalmol 2006;124:597–599]. The high evidence shown by these studies supported the rationale to use PDT also in additional, less frequent, vasoproliferative diseases. Although these ‘case series’ and ‘individual case control studies’ have a low level of evidence, they give us important information for treatment decisions in these rare conditions. The goal of this survey is to review the current literature regarding PDT in vasoproliferative and exudative ocular diseases outside AMD. Many studies modified the treatment parameters of PDT to address the specific pathology of the underlying disease. Table 1 summarizes the diseases and treatment parameters that are described in this part 2, the entire table of this review is included in part 1 (www.karger.com/doi/10.1159/ 000101922).

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Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapy

Abstract: The present series demonstrates that even limited, low-irradiance, single-spot photodynamic therapy with verteporfin is an effective first-line treatment for choroidal hemangiomas.

Cited by 51 publications

References 37 publications

Circumscribed choroidal hemangioma

Circumscribed choroidal hemangioma

Application of the Standard Photodynamic Treatment Protocol for Symptomatic Circumscribed Choroidal Hemangioma

Ocular Photodynamic Therapy – Standard Applications and New Indications (Part 2)

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