Transmission of anti-HCV within the household of haemodialysis patients

Calabrese, G; Vagelli, G; Guaschino, Roberto; Gonella, M.

doi:10.1016/0140-6736(91)92774-v

Cited by 55 publications

(36 citation statements)

References 4 publications

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“…In our study, HCV infection increased with age, as supported by previous studies (24,25). This rate reached 6.2% in subjects between 50-59 years of age and 7.5% in subjects older than 60 years of age.…”

Section: Discussionsupporting

confidence: 92%

Risk factors for higher anti-HCV positivity in a border city in southern Turkey with unique population characteristics

Özer

Seydaoğlu²,

Ozsahin³

et al. 2012

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 92%

Risk factors for higher anti-HCV positivity in a border city in southern Turkey with unique population characteristics

Özer

Seydaoğlu²,

Ozsahin³

et al. 2012

Turk J Gastroenterol

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“…Esses pacientes apresentaram duração de hemodiálise como o principal fator de risco, levando os investigadores a sugerirem a hemodiálise como via de transmissão do vírus C. A observação de que hemodiálise a longo prazo tem importante papel na infecção pelo vírus C é similar a relatos do Japão, Alemanha e Itália (10,18,19,27,30) . CALABRESE et al (3) avaliaram 56 pacientes em unidade de hemodiálise utilizando o ELISA II e RIBA III e detectaram anti-VHC em 29 pacientes (52%), dos quais 5 (18%) tinham provável contaminação através de transfusão e 2 (7%) por cirurgia dentária. Após medidas como o uso de ambiente e máquinas exclusivas para pacientes anti-VHC positivos, os autores relataram redução na incidência anual de soroconversão de 20% para 0%.…”

Section: Discussionunclassified

Anticorpo contra o vírus C da hepatite em pacientes sob programa de hemodiálise em Salvador, BA, Brasil

Santana

Cotrim

Mota

et al. 2001

Arq. Gastroenterol.

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RESUMO -Racional -A prevalência da infecção pelo vírus da hepatite C em pacientes sob programa de hemodiálise tem sido amplamente variável. Objetivos -Determinar a prevalência do anticorpo contra o vírus C da hepatite (anti-VHC INTRODUÇÃODesde as publicações iniciais sobre o vírus da hepatite C (VHC), observou-se que este era o principal agente da hepatite não-A não-B, sobretudo na forma pós-transfusional (2,5,17) e se associa à doença hepática crônica (25) e carcinoma hepatocelular (6,21) . Entre pacientes sob hemodiálise, a prevalência da infecção pelo VHC, reconhecida pela presença do seu anticorpo (anti-VHC), varia de 1 a 48%, de acordo com vários estudos (4,14,18,23) .A prevalência do anti-VHC entre pacientes hemodialisados é inadequada quando se utiliza testes sorológicos que determinam apenas anticorpo para proteína C100-3 como marcador de infecção VHC, uma vez que a reatividade desses pacientes para proteínas estruturais e outras não-estruturais não foi caracterizada. Os estudos mais recentes, utilizando os testes de segunda geração, mostraram soro-positividade de 10% a 30% (20,22) . Os testes confirmatórios por Immunoblotting (RIBA III) também evoluíram, utilizando proteínas virais diferentes,

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“…Some of these advances were the introduction of recombinant erythropoietin for the treatment of anemia that eliminated the need for regular blood transfusion, the routine anti-HCV screening test implemented at the blood centers preventing the transfusion route of HCV transmission, the modernization of new dialysis equipment, and the requirement of periodic anti-HCV screening of all patients undergoing hemodialysis treatment that permitted the individualization of treatment. Calabrese et al (28) and others (29) showed that by dialyzing HCV-positive patients using separate equipment in a dedicated area (but not a separate room) led to a striking reduction in the incidence of HCV infection.…”

Section: Lk Silva Et Almentioning

confidence: 99%

Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil

Silva

Rodart

et al. 2006

Braz J Med Biol Res

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Hepatitis C virus (HCV) infection has been identified as the major cause of chronic liver disease among patients on chronic hemodialysis (HD), despite the important reduction in risks obtained by testing candidate blood donors for anti-HCV antibodies and the use of recombinant erythropoietin to treat anemia. A cross-sectional study was performed to estimate the prevalence of HCV infection and genotypes among HD patients in Salvador, Northeastern Brazil. Anti-HCV seroprevalence was determined by ELISA in 1243 HD patients from all ten different dialysis centers of the city. HCV infection was confirmed by RT-PCR and genotyping was performed by restriction fragment length polymorphism. Anti-HCV seroprevalence among HD patients was 10.5% (95% CI: 8.8-12.3) (Murex anti-HCV, Abbott Murex, Chicago, IL, USA). Blood samples for qualitative HCV detection and genotyping were collected from 125/130 seropositive HD patients (96.2%). HCV-RNA was detected in 92/125 (73.6%) of the anti-HCV-positive patients. HCV genotype 1 (77.9%) was the most prevalent, followed by genotype 3 (10.5%) and genotype 2 (4.6%). Mixed infections of genotypes 1 and 3 were found in 7.0% of the total number of patients. The present results indicate a significant decrease in anti-HCV prevalence from 23.8% detected in a study carried out in 1994 to 10.5% in the present study. The HCV genotype distribution was closely similar to that observed in other hemodialysis populations in Brazil, in local candidate blood donors and in other groups at risk of transfusion-transmitted infection.

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Transmission of anti-HCV within the household of haemodialysis patients

Cited by 55 publications

References 4 publications

Risk factors for higher anti-HCV positivity in a border city in southern Turkey with unique population characteristics

Risk factors for higher anti-HCV positivity in a border city in southern Turkey with unique population characteristics

Anticorpo contra o vírus C da hepatite em pacientes sob programa de hemodiálise em Salvador, BA, Brasil

Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil

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