Risk factors for higher anti-HCV positivity in a border city in southern Turkey with unique population characteristics

Özer, Birol; Seydaoğlu, Gülşah; Ozsahin, Akatli Kursat; Demırhındı, Hakan

doi:10.4318/tjg.2012.0554

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…Another study conducted by Ozer et al . found that anti-HCV positivity was higher in married patients [ 20 ]. The seroprevalence of HCV in smaller groups in different parts of Turkey was shown to range between 0 and 3.9% [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Original paper Serological test results of sexually transmitted diseases in patients with condyloma acuminata

Ünal¹,

Gönül

Çakmak

et al. 2015

pdia

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IntroductionHuman papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases (STD). The incidence of condyloma acuminata (CA) has increased in recent years.AimTo determine demographical features and serological test results of STD in patients with CA.Material and methodsA cross-sectional survey was conducted on 94 patients presenting to a dermatology clinic in Ankara, Middle Anatolia, Turkey. Dermatological examinations were made and the patients completed a questionnaire which consisted of questions about their marital status, partners and condom use. In all cases, VDRL/RPR, anti-HIV, HBsAg, anti-HCV and in 57 cases – HSV type 1–2 IgM and IgG were studied. If the value of VDRL or RPR was positive, TPHA was conducted.ResultsIn our study, 83 men and 11 women had CA. We could not analyze whether our cases had multiple partners and a habit of condom use as some of the patients did not answer questions about their sexual life. We observed VDRL and TPHA positivity in 3 (3.1%) cases, none of those cases had clinical findings of syphilis and they denied using any therapy for syphilis. HBsAg positivity was found in 3 cases. No anti-HIV and anti-HCV antibody positivity was detected.ConclusionsThe seroprevalence of HBsAg in our study was similar to that of the general population of Turkey. But as we found positive syphilis serology in 3 patients, we suggest that syphilis serology should be investigated in patients with CA.

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Section: Discussionmentioning

confidence: 99%

Original paper Serological test results of sexually transmitted diseases in patients with condyloma acuminata

Ünal¹,

Gönül

Çakmak

et al. 2015

pdia

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“…Although the Türkiye Hepatitis Prevalence (TURKHEP) study reported a nationwide seroprevalence of 1%, some regions have results as high as 3.1% (25,26). Prevalence increases after the age of 50.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Interleukin-28B Gene rs12979860 C/T Polymorphism in Turkish Chronic Hepatitis C Patients and Healthy Individuals

Taheri¹,

Aygen²,

Korkmaz³

et al. 2015

Balkan Med J

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Background: Host genetic factors can affect the progress of hepatitis-C virus (HCV) infection. Interleukin-28B (IL28B) single nucleotide polymorphisms may play an important role in the clearance of HCV spontaneously or with treatment. Aims: The aim of our study was to evaluate the rate of IL28B genotypes in patients with Chronic Hepatitis-C (CHC) and healthy control subjects and to examine the characteristics of patients in each IL28B subgroup. Study Design: Case-control study. Methods: IL28B polymorphisms were genotyped by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) in all subjects. Results: The mean age was 52.3±10.9 years (33% female) in the CHC patients and 52.5±11.5 years (39.1% female) in the healthy controls. The percentage of patients with a high baseline viral load (≥400,000 IU/mL) was higher in the CT group (69.8%) compared to the C/C (44.4%) and T/T (50%) groups (p=0.021). There was no significant difference in liver fibrosis and liver necroinflammation distribution among the CC, CT and TT genotypes with mild, moderate and severe groups (p=0.058 and p=0.791, respectively). Mean age, gender ratio, body mass index, viral load at baseline, rate of HCV genotypes, baseline ALT levels were not significantly different among the three IL28B subgroups (p>0.05). A significant increase was observed in the frequencies of IL28B rs12979860 TT genotypes in the CHC patients (20.6%) compared to the healthy control group (8.7%) (p=0.033). Conclusion: In the patients with chronic HCV-genotype 1b and 4 infections, the IL28B rs12979860 (C>T) gene polymorphism frequency of the TT genotype and T allele was higher than in healthy control subjects. This result indicates that the TT genotype may be more effective in the progression of HCV infection than other genotypes.

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“…In a study, which is related to risk factors of hepatitis, C in a border city of Southern Anatolia in Turkey it was found that risk factors might vary compared to overall country. Previous dental procedures and working abroad in neigbouring countries seem to play a role in this difference [14]. In a study related to healthcare associated risk factors for Chronic Hepatitis C infection in Korea it was observed that having multiple sex partners play a minor role in transmission [15].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Risk Factors Frequencies of Hepatitis C in Two Provinces

Dagli¹

2016

J Infect Dis Preve Med

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Risk factors for transmission routes of hepatitis C virus (HCV) may vary in countries like Turkey which has geographical, cultural and socioeconomical differences among regions. In this study data from two provinces of Turkey were analysed to evaluate and compare the risk factors frequencies of HCV. From 2007 through 2014, a total of anti-HCV positive 90 patients from Bursa Yuksek Ihtisas Research and Training Hospital located in the west region of Turkey and 100 patients from Kilis State Hospital located in the south east part were included in the study to compare risk factors of HCV infection. Patients were questioned about history of dental treatment, hospitalization, blood transfusion, surgical operation and intravenous drug use which are major risk factors for transmission of HCV. Overall history of previous dental treatment was the most prevalent risk factor in both provinces followed by hospitalization, blood transfusion and operation. The use of intravenous drugs was higher in Kilis with a statistically significant difference. In every patient at least one risk factor was present. Although Kilis has a conservative community and lower socio economical level, this unexpected observation may be related to reflections of border trade of drugs on society. Thus preventive measures should be taken, considering socioeconomical differences among regions.

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Risk factors for higher anti-HCV positivity in a border city in southern Turkey with unique population characteristics

Abstract: p= 0.0001) ve e¤itimsizlerde (5.0%) (OR:2.7, p=0.021)

Cited by 10 publications

References 29 publications

Original paper Serological test results of sexually transmitted diseases in patients with condyloma acuminata

Original paper Serological test results of sexually transmitted diseases in patients with condyloma acuminata

Characterization of the Interleukin-28B Gene rs12979860 C/T Polymorphism in Turkish Chronic Hepatitis C Patients and Healthy Individuals

Comparison of Risk Factors Frequencies of Hepatitis C in Two Provinces

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