Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines

Abstract

Abstract:Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.

Active Transiency: A Novel Approach to Expedite Degradation in Transient Electronics

“…Early works on transient materials and electronics can be divided into three main categories: (i) electronics on bioresorbable substrates [11], (ii) partially transient electronics with specific degradable components [2], and (iii) fully dissolvable electronics [12]. Most of the previous studies in this field have focused on dissolution based transiency [1,[12][13][14][15][16][17][18]. Thermally and optically triggered transiency have also been studied [19][20][21], yet to a lesser extent.…”

“…Gelatin is used as a means to increase the stiffness of precursor film due to the presence of triple helixes in its structure, and thus facilitate PVA-gelatin's powder formation [14]. PEO was intended to enhance the flexibility of the substrate due to its low molecular weight [13]. Findings reported here could be extended to other material systems, consisting of different matrices and gas-forming agents, to enhance selectivity and limit transiency to more specific conditions such as pH and temperature, among others.…”

“…Gelatin is used as a means to increase the stiffness of precursor film due to the presence of triple helixes in its structure, and thus facilitate PVA-gelatin's powder formation [14]. PEO was intended to enhance the flexibility of the substrate due to its low molecular weight [13]. Materials 2020, 12, x FOR PEER REVIEW 2 of 10 Author Contributions: Conceptualization, R.M.…”

Fiber Based Approaches as Medicine Delivery Systems

“…Therefore, the success of an extant or potential application of a drug delivery system innately depends on the choice of the drug carrier. [1][2][3][4] Researchers have considered numerous carriers over the past few decades, 5,6 and micro and nanofibers have become an attractive prospective carrier option. [7][8][9][10][11][12][13] This could be attributed to both the nature of the material used to fabricate the fiber and the nature of this very fabrication process.…”

High performance transient organic solar cells on biodegradable polyvinyl alcohol composite substrates

“…PVA, which is insulated and can be processed in water at a low temperature, is utilized as the substrate due to its desirable optical transmittance, exibility, mechanically robust and high water-solubility. 34 Importantly, the dissolution and transiency of PVA lms can be programmed by introduction of llers to the PVA polymer matrix. Also, the ability of PVA to be served as substrates and encapsulation layers for various transient electronic devices has been demonstrated.…”