Fiber Based Approaches as Medicine Delivery Systems

Sharifi, Farrokh; Sooriyarachchi, Avinash C.; Altural, Hayriye; Montazami, Reza; Rylander, Marissa Nichole; Hashemi, Nastaran

doi:10.1021/acsbiomaterials.6b00281

Cited by 91 publications

(67 citation statements)

References 148 publications

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“…[2][3][4][5][6] Of the ber-forming processes, electrospinning has been widely adopted as a versatile method to produce brous vehicles with ne-tuned morphology for effective delivery of therapeutic agents. [1][2][3]5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20] For example, multi-axial electrospinning has been utilized to produce multi-compartmental bers that allow multiple release stages or multi-drug delivery. 5,10,18 This conguration has a potential application of treating patients who have developed resistance to specic drugs.…”

Section: Introductionmentioning

confidence: 99%

Early stage release control of an anticancer drug by drug-polymer miscibility in a hydrophobic fiber-based drug delivery system

Yuan

Choi

et al. 2018

RSC Adv.

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The drug release profiles of doxorubicin-loaded electrospun fiber mats were investigated with regard to drug-polymer miscibility, fiber wettability and degradability. Doxorubicin in hydrophilic form (Dox-HCl) and hydrophobic free base form (Dox-base) was employed as model drugs, and an aliphatic polyester, poly(lactic acid) (PLA), was used as a drug-carrier matrix. When hydrophilic Dox-HCl was directly mixed with PLA solution, drug molecules formed large aggregates on the fiber surface or in the fiber core, due to poor drug-polymer compatibility. Drug aggregates on the fiber surface contributed to the rapid initial release. The hydrophobic form of Dox-base was dispersed better with PLA matrix compared to Dox-HCl.When dimethyl sulfoxide (DMSO) was used as the solvent for Dox-HCl, the miscibility of drug in the polymer matrix was significantly improved, forming a quasi-monolithic solution scheme. The drug release from this monolithic matrix was slowest, and this slow release led to a lower toxicity to hepatocellular carcinoma. When an enzyme was used to promote PLA degradation, the release rates were closely correlated with degradation rates, demonstrating degradation was the dominant release mechanism. The possible drug release mechanisms were speculated based on the release kinetics. The results suggest that manipulation of drug-polymer miscibility and polymer degradability can be an effective means of designing drug release profiles.

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Section: Introductionmentioning

confidence: 99%

Early stage release control of an anticancer drug by drug-polymer miscibility in a hydrophobic fiber-based drug delivery system

Yuan

Choi

et al. 2018

RSC Adv.

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“…Furthermore, high voltages (5−50 kV) need to be applied for pulling the charged solution, which might damage sensitive biological materials. 32 Wet spinning method has been employed in nerve tissue engineering as well. Siriwardane et al fabricated collagen fibers and treated them by cross-linkers glutaraldehyde and genipin in order to improve the mechanical properties and decrease swelling.…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone Microfibrous Scaffolds to Navigate Neural Stem Cells

et al. 2016

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Fibrous scaffolds have shown promise in tissue engineering due to their ability to improve cell alignment and migration. In this paper, poly(ε-caprolactone) (PCL) fibers are fabricated in different sizes using a microfluidic platform. By using this approach, we demonstrated considerable flexibility in ability to control the size of the fibers. It was shown that the average diameter of the fibers was obtained in the range of 2.6−36.5 μm by selecting the PCL solution flow rate from 1 to 5 μL min −1 and the sheath flow rate from 20 to 400 μL min −1 in the microfluidic channel. The microfibers were used to create 3D microenvironments in order to investigate growth and differentiation of adult hippocampal stem/progenitor cells (AHPCs) in vitro. The results indicated that the 3D topography of the PCL substrates, along with chemical (extracellular matrix) guidance cues supported the adhesion, survival, and differentiation of the AHPCs. Additionally, it was found that the cell deviation angle for 44−66% of cells on different types of fibers was less than 10°. This reveals the functionality of PCL fibrous scaffolds for cell alignment important in applications such as reconnecting serious nerve injuries and guiding the direction of axon growth as well as regenerating blood vessels, tendons, and muscle tissue.

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“…Recently, microfluidic platforms have shown promise to a wide range of applications from biomedical to energy areas . Microfluidic fiber fabrication is versatile, straightforward, cost‐effective, and biocompatible.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] Recently, microfluidic platforms have shown promise to a wide range of applications from biomedical to energy areas. [14][15][16][17][18][19][20] Microfluidic fiber fabrication is versatile, straightforward, cost-effective, and biocompatible. Furthermore, this approach does not require high temperature, pressure, and voltage to fabricate fibers as is necessary for conventional methods.…”

Section: Introductionmentioning

confidence: 99%

3D Microfibrous Scaffolds Selectively Promotes Proliferation and Glial Differentiation of Adult Neural Stem Cells: A Platform to Tune Cellular Behavior in Neural Tissue Engineering

Patel

Sharifi

Stroud

et al. 2018

Macromolecular Bioscience

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Biomaterials are essential for the development of innovative biomedical and therapeutic applications. Biomaterials‐based scaffolds can influence directed cell differentiation to improve cell‐based strategies. Using a novel microfluidics approach, poly (ε‐caprolactone) (PCL), is used to fabricate microfibers with varying diameters (3–40 µm) and topographies (straight and wavy). Multipotent adult rat hippocampal stem/progenitor cells (AHPCs) are cultured on 3D aligned PCL microfibrous scaffolds to investigate their ability to differentiate into neurons, astrocytes, and oligodendrocytes. The results indicate that the PCL microfibers significantly enhance proliferation of the AHPCs compared to control, 2D planar substrates. While the AHPCs maintained their multipotent differentiation capacity when cultured on the PCL scaffolds, there is a significant and dramatic increase in immunolabeling for astrocyte and oligodendrocyte differentiation when compared with growth on planar surfaces. Our results show a 3.5‐fold increase in proliferation and 23.4‐fold increase in astrocyte differentiation for cells on microfibers. Transplantation of neural stem/progenitor cells within a PCL microfiber scaffold may provide important biological and topographic cues that facilitate the survival, selective differentiation, and integration of transplanted cells to improve therapeutic strategies.

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Fiber Based Approaches as Medicine Delivery Systems

Cited by 91 publications

References 148 publications

Early stage release control of an anticancer drug by drug-polymer miscibility in a hydrophobic fiber-based drug delivery system

Early stage release control of an anticancer drug by drug-polymer miscibility in a hydrophobic fiber-based drug delivery system

Polycaprolactone Microfibrous Scaffolds to Navigate Neural Stem Cells

3D Microfibrous Scaffolds Selectively Promotes Proliferation and Glial Differentiation of Adult Neural Stem Cells: A Platform to Tune Cellular Behavior in Neural Tissue Engineering

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