Transdermal microgels of gentamicin

Nnamani, Petra O.; Kenechukwu, Franklin Chimaobi; Dibua, Esther Uju; Ogbonna, Chimaobi Samuel; Monemeh, U L; Attama, Anthony A.

doi:10.1016/j.ejpb.2012.11.015

Cited by 23 publications

(41 citation statements)

References 20 publications

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“…Phospholipid‐modified solid lipid microparticles encapsulating GEN were loaded into different polymer hydrogels. Among them, poloxamer 407 microgels displayed the most desirable properties specifically rapid antibacterial activity, in vitro diffusion‐dependent permeation, ability to spread, and appropriate viscosity 78. These results indicated that the same drug can achieve different diffusion speeds on hydrogels due to the different matrices being employed.…”

Section: Antibiotic‐loaded Hydrogelsmentioning

confidence: 98%

Antibacterial Hydrogels

et al. 2018

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Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research. Many advanced antibacterial hydrogels are developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs, and structural diversity. Here, an overview of the structures, performances, mechanisms of action, loading and release behaviors, and applications of various antibacterial hydrogel formulations is provided. Furthermore, the prospects in biomedical research and clinical applications are predicted.

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Section: Antibiotic‐loaded Hydrogelsmentioning

confidence: 98%

Antibacterial Hydrogels

et al. 2018

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“…Solid lipid microparticles (SLMs) combine the advantages of different traditional carriers; for example, they can be produced on a large industrial scale and allow controlled release of incorporated drug (El-Kamel et al, 2007;Kenechukwu et al, 2011;Chime et al, 2012a,b;Umeyor et al, 2012a,c;Nnamani et al, 2013). Homolipids and heterolipids have gained renewed interests as excipients for LBDDS (Attama & Muller-Goymann, 2006.…”

Section: Introductionmentioning

confidence: 97%

Solid lipid micro-dispersions (SLMs) based on PEGylated solidified reverse micellar solutions (SRMS): a novel carrier system for gentamicin

Kenechukwu¹,

Momoh²,

Nnamani³

et al. 2014

Drug Delivery

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The purpose of this study was to formulate and evaluate novel PEGylated solidified reverse micellar solutions (SRMS)-based solid lipid microparticles (SLMs) for improved delivery of gentamicin. Lipid matrix (SRMS) [consisting of 15% w/w Phospholipon® 90G (P90G) in 35% w/w dika wax (Irvingia gabonensis) was formulated and characterized by differential scanning calorimetry (DSC). SLMs were formulated by melt-emulsification using the SRMS, PEG 4000 and gentamicin (1.0, 2.0, 3.0% w/w), and their physicochemical as well as pharmacokinetic parameters determined. In vitro permeation of gentamicin from the SLMs through artificial membrane (0.22 μm pore size) was carried out using Franz's cell and phosphate-buffered saline (PBS, pH 7.4) as acceptor medium, while bioevaluation was performed using clinical isolates of Pseudomonas aeruginosa and Staphylococcus aureus. Stable and irregularly-shaped gentamicin-loaded SLMs of size range 34.49 ± 2.56 to 53.52 ± 3.09 µm were obtained. The SLMs showed sustained drug permeation and exhibited time-dependent and capacity-limited bioactivity. Overall, SLMs containing 2% w/w SRMS, 3% w/w gentamicin and PEG 4000 entrapped the highest amount of drug, gave highest IZD against the test organisms and highest permeation flux (5.239 μg/cm(2).min) and permeation coefficient (1.781 × 10(-6)cm/min) within 420 min, while pure gentamicin gave the least. Preliminary in vivo pharmacokinetic studies also showed an AUC-24 of 1507 µg/h/ml for the optimized formulation, while that of oral drug solution was 678 µg/h/ml. This showed a 2.2-fold increase in the systemic bioavailability of gentamicin from the optimized formulation. PEGylated SRMS-based SLMs prepared with heterolipid from Irvingia gabonensis would likely offer a reliable delivery system for gentamicin.

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“…The increased viscosity of the drug-loaded hydrogels compared with the plain hydrogels may be related to the additional drug content in the formulation compositions of the former. Viscosity of the gel matrix is an important factor to consider in evaluation of drug penetration from gels across the skin or artificial membrane and is used to measure the extrudability of a gel [14]. The decreased viscosity of the hydrogels at high drug loadings (batches A2-C2 and A3-C3) not only implies that these hydrogel formulations would be easily extruded from their containers or packages but also indicates potential improvement in the diffusivity of gentamicin within the hydrogel network which in turn would facilitate flux, consistent with previous report [14].…”

Section: Discussionmentioning

confidence: 99%

“…Stability could be viewed from the degradation of the active ingredients or physical property of the formulation [14]. In order to determine the change in drug content on storage, stability study was carried out on the gentamicin-loaded hydrogels before and after storage for three months.…”

Section: Discussionmentioning

confidence: 99%