Antibacterial Hydrogels

Li, Shuqiang; Dong, Shujun; Xu, Weiguo; Tu, Shicheng; Yan, Lesan; Zhao, Changwen; Ding, Jianxun; Chen, Xuesi

doi:10.1002/advs.201700527

Cited by 747 publications

(518 citation statements)

References 174 publications

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“…[1][2][3] The incorporation of electroconductive elements to hydrogels is an attractive design approach that combines the viscoelastic and mechanical properties of hydrogels with the conductivity of organic electronics. Various characteristics, such as swelling degree, water content, stiffness, porosity, viscoelastic properties, and biocompatibility can be tailored for different applications.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

Patsis

Hauser

et al. 2019

Advanced Science

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Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity and high biocompatibility, injectability and adhesiveness are important for many biomedical applications but have proven to be very challenging. Recent results show that fascinating material properties can be realized with a bioinspired hybrid network, especially through the synergy between irreversible covalent crosslinking and reversible noncovalent self‐assembly. Herein, a polysaccharide‐based conductive hydrogel crosslinked through noncovalent and reversible covalent reactions is reported. The hybrid material exhibits rheological properties associated with dynamic networks such as self‐healing and stress relaxation. Moreover, through fine‐tuning the network dynamics by varying covalent/noncovalent crosslinking content and incorporating electroconductive polymers, the resulting materials exhibit electroconductivity and reliable adhesive strength, at a similar range to that of clinically used fibrin glue. The conductive soft adhesives exhibit high cytocompatibility in 2D/3D cell cultures and can promote myogenic differentiation of myoblast cells. The heparin‐containing electroconductive adhesive shows high biocompatibility in immunocompetent mice, both for topical application and as injectable materials. The materials could have utilities in many biomedical applications, especially in the area of cardiovascular diseases and wound dressing.

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Section: Introductionmentioning

confidence: 99%

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

Patsis

Hauser

et al. 2019

Advanced Science

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“…It could reflect that OGP–CIP could kill and reduce bacteria count effectively. Previous studies have pointed out that CIP kills bacteria by binding to the DNA gyrases and causing double‐stranded ruptures in bacterial chromosomes …”

Section: Discussionmentioning

confidence: 99%

“…It is worth mentioning that antibiotics (e.g., vancomycin, gentamicin, ciprofloxacin—though may induce bacterial antibiotic resistance) are widely used as they can rapidly and effectively against a broad spectrum of bacteria . Ciprofloxacin (CIP), as a representative synthetic antimicrobial agent, is efficaciously against both Gram‐positive and ‐negative strains, including some strains resistant to penicillin, cephalosporins, and aminoglycosides . Except for the broad spectrum antimicrobial activity, CIP is the least expensive drug in the fluoroquinolone family and is already FDA approved and indicated for bone and joint infections …”

Section: Introductionmentioning

confidence: 99%

“…17,[36][37][38][39] Ciprofloxacin (CIP), as a representative synthetic antimicrobial agent, is efficaciously against both Gram-positive and -negative strains, including some strains resistant to penicillin, cephalosporins, and aminoglycosides. [40][41][42][43] Except for the broad spectrum antimicrobial activity, CIP is the least expensive drug in the fluoroquinolone family and is already FDA approved and indicated for bone and joint infections. 43 Recently, several studies have shown that dual delivery of an antibiotic and a growth factor could address both the microbiological and biological challenges of contaminated bone fractures.…”

Section: Introductionmentioning

confidence: 99%

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Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

Liu

Yang

Tao

et al. 2018

J Biomedical Materials Res

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The inherent bioinertness and potential bacterial infection risk are the two leading causes for Ti implant failure. To improve osseointegration and antibiosis, in this work, a novel antimicrobial osteogenic growth peptide was first synthesized by conjugating osteogenic growth peptide (OGP) and ciprofloxacin (CIP). Then, the synthetic antimicrobial peptide was immobilized onto Ti implant surface for chemoselective binding via the amide reaction. Thereafter, the capabilities of modified Ti implant on osseointegration and antibiosis were measured with cell experiments and antimicrobial activity in vitro. The results showed that antimicrobial osteogenic growth peptide (OGP-CIP) was successfully prepared and grafted onto Ti implant surface. Moreover, the antimicrobial peptide-modified Ti implants could promote osteoblasts spreading and osteodifferentiation compared with unmodified Ti substrates. Meanwhile, in vitro bacteria studies (Staphylococcus aureus and Escherichia coli) proved that the antibacterial property of antimicrobial peptide functionalized Ti implant was improved obviously. The method used in this work is a feasible and promising strategy to win the race against invading bacteria and accelerate bone integration in orthopedic implantation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3021-3033, 2018.

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“…Antibacterial Evaluation : Antibacterial activity of the GHK‐Cu monomers and self‐assembled GHK‐Cu NPs was performed by the standard disc diffusion method . The overnight grown bacterial suspensions of S. aureus and E. coli were swabbed on separate nutrient agar plates using L‐rod.…”

Section: Methodsmentioning

confidence: 99%

Self‐Assembled Fluorescent and Antibacterial GHK‐Cu Nanoparticles for Wound Healing Applications

Sun

et al. 2019

Part & Part Syst Charact

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GHK‐Cu is demonstrated with the abilities to improve wound healing, accelerate anti‐inflammatory activity, and repair DNA damage. However, the instability of the GHK‐Cu in biological fluids is always a big challenge for its long‐term and efficient function at the target site. Therefore, the self‐assembled GHK‐Cu nanoparticles (GHK‐Cu NPs) are investigated in this work to solve the instability issue. The crystalline nanostructure within the GHK‐Cu nanoparticles offers them visible and near‐infrared fluorescent properties. With the excellent self‐assembly performance, the antibacterial properties of GHK‐Cu NPs are demonstrated using E. coli and S. aureus. The L929 dermal fibroblast cells are utilized to prove the good biocompatibility and enhanced wound healing applications of GHK‐Cu NPs. This study could pave the way for the design and elaboration of a new class of fluorescent peptides with various biological functions in biomedical applications.

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Antibacterial Hydrogels

Cited by 747 publications

References 174 publications

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

Self‐Assembled Fluorescent and Antibacterial GHK‐Cu Nanoparticles for Wound Healing Applications

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