Tragacanth gum  as a natural polymeric wall for producing antimicrobial nanocapsules loaded with plant extract

Ghayempour, Soraya; Montazer, Majid; Rad, Mahnaz Mahmoudi

doi:10.1016/j.ijbiomac.2015.08.041

Cited by 87 publications

(35 citation statements)

References 30 publications

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“…Then they were incubated into a humidified incubator containing 5% CO2 at 37 °C. Afterwards cells were sub-cultured into 96-well plates and 6-well plates throughout different steps of the work [18,19].…”

Section: Caco-2 Cell Culturementioning

confidence: 99%

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Attenuation of Intestinal Efflux Pump thru Polymers and Preservatives

Zakeri–Milani¹,

Baradaran²,

Yousefi³

et al. 2019

jrp

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P-glycoprotein (P-gp), the efflux membrane protein found in the upper exterior of epithelial cells in human intestine, is capable of exhibiting variations in the intestinal transport. This study was set with the purpose of testing the capability often pharmaceutical excipients namely Carbopol, Xanthan, Tragacanth, Sodium Benzoate, Hydroxypropyl methylcellulose, Methylparaben, Methylcellulose, Cetyltrimethylammonium bromide and Vitamin E in regulating P-gp protein expression and the multidrug resistance (MDR1) gene, by means of a monolayer of human colon cancer cell line (Caco-2). Using MTT test, the least sub-toxic concentrations of mentioned excipients were assessed in Caco-2 cells. Subsequently the impact of the excipients on P-gp activity was evaluated by quantifying the amount of Rhodamine-123 uptake into cells. Besides, P-glycoprotein expression was scrutinized via Western-blotting. Among the tested excipients, Tragacanth and Xanthan showed a similar western blotting and Rhodamine-123 assay results as the control group. Carbopol 934, Vitamin E, and Methylcellulose showed 27.2%, 43% and 50.9% increase in Rhodamine accumulation, respectively. According to the obtained results it is concluded that using appropriate concentrations of the Carbopol 934, Vitamin E and Methylcellulose can attenuate the P-gp activity and expression where such reduction ought to be taken into consideration due to its role in the changes of permeability and absorption of the pharmaceutical compounds.

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Section: Caco-2 Cell Culturementioning

confidence: 99%

“…Tragacanth gum which is a biodegradable and biocompatible polymer that is used as an emulsifying agent, rheology enhancer, etc. [18]. Carbopol Polymer is a self-wetting, rheology modifier designed to be used as a thickener, suspending agent and stabilizer in cosmetic manufacturing.…”

mentioning

confidence: 99%

Attenuation of Intestinal Efflux Pump thru Polymers and Preservatives

Zakeri–Milani¹,

Baradaran²,

Yousefi³

et al. 2019

jrp

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“…However, additional functionality in the hydrogel may be created by graft polymerization of specific monomers with desired chemistry. Graft polymerization is the process where a monomer undergoes polymerization in the vicinity of a polymer chain so that a branched structure is created where the branches are formed along the polymer backbone . The beauty of this system is that desired features may be incorporated within the graft copolymer via the precise selection of the monomer while the base polymer still retains most of its inherent characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…Graft polymerization is the process where a monomer undergoes polymerization in the vicinity of a polymer chain so that a branched structure is created where the branches are formed along the polymer backbone. 2 The beauty of this system is that desired features may be incorporated within the graft copolymer via the precise selection of the monomer while the base polymer still retains most of its inherent characteristics. The physicochemical nature of a graft copolymer therefore depends on the extent of the grafting which in turn is governed by the grafting parameters.…”

Section: Introductionmentioning

confidence: 99%

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma

Negi

Pathania

et al. 2018

Polymer International

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Graft polymerization of itaconic acid on tragacanth gum (TG) was carried out using potassium persulfate as initiator to develop smart hydrogels for drug delivery systems. The effect of the grafting parameters on the degree of grafting was investigated. The grafting was significantly influenced by the reaction medium, the reaction temperature and the monomer concentration. The monomer dependency of the system was found to be 1.52. The hydrogels were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry and X‐ray diffraction. The grafted TG had an amorphous nature and exhibited excellent swelling in water and strong dependence on the pH of the medium. The grafted TG showed pH‐dependent release of ciprofloxacin which offers the possibility of using these materials in colon‐specific drug targeting for human healthcare systems. © 2018 Society of Chemical Industry

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“…Tragacanth gum (TG), a natural polysaccharide, is widely utilized as stabilizer, emulsifier and thickener due to its stability in a wide range of pH and temperature and high viscosity [1,22,23]. Darroudi et al used TG to synthesize ZnO nanoparticles by sol-gel method at different calcination temperatures and evaluated its cytotoxic effects [24,25].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound irradiation based in-situ synthesis of star-like Tragacanth gum/zinc oxide nanoparticles on cotton fabric

Ghayempour

Montazer

2017

Ultrasonics Sonochemistry

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103

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Application of natural biopolymers for green and safe synthesis of zinc oxide nanoparticles on the textiles is a novel and interesting approach. The present study offers the use of natural biopolymer, Tragacanth gum, as the reducing, stabilizing and binding agent for in-situ synthesis of zinc oxide nanoparticles on the cotton fabric. Ultrasonic irradiation leads to clean and easy synthesis of zinc oxide nanoparticles in short-time at low-temperature. FESEM/EDX, XRD, FT-IR spectroscopy, DSC, photocatalytic activities and antimicrobial assay are used to characterize Tragacanth gum/zinc oxide nanoparticles coated cotton fabric. The analysis confirmed synthesis of star-like zinc oxide nanoparticles with hexagonal wurtzite structure on the cotton fabric with the average particle size of 62nm. The finished cotton fabric showed a good photocatalytic activity on degradation of methylene blue and 100% antimicrobial properties with inhibition zone of 3.3±0.1, 3.1±0.1 and 3.0±0.1mm against Staphylococcus aureus, Escherichia coli and Candida albicans.

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Tragacanth gum as a natural polymeric wall for producing antimicrobial nanocapsules loaded with plant extract

Cited by 87 publications

References 30 publications

Attenuation of Intestinal Efflux Pump thru Polymers and Preservatives

Attenuation of Intestinal Efflux Pump thru Polymers and Preservatives

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Ultrasound irradiation based in-situ synthesis of star-like Tragacanth gum/zinc oxide nanoparticles on cotton fabric

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