Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma, Chetna; Negi, Poonam; Pathania, Deepak; Sethi, Vipula; Gupta, Bhuvanesh

doi:10.1002/pi.5739

Cited by 25 publications

(21 citation statements)

References 45 publications

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“…Graft polymers are also known as graft copolymers and comprise of at least two different types of monomer parts, such as the grafted side chains that are structurally different from the main chain. The monomer to be grafted may be of one or more than one kind; thus, the graft chains in the grafted copolymer may be homopolymers or copolymers [ 54 ].…”

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

196

111

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Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.

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Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

196

111

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“…The resultant TG-g-PIA (GTG) was dried under vacuum oven at 80C to a constant weight. The degree of grafting was determined as per the following equation [10].…”

Section: Graft Polymerizationmentioning

confidence: 99%

“…Therefore, it becomes difficult to investigate the fraction of water being absorbed by each of the functional groups. We have been working on the development of functional hydrogels by graft polymerization of itaconic acid on TG by microwave irradiation and chemical initiation [10,11]. We have been working on the development of tragacanth gum-gpolyitaconic acid hydrogels which may exhibit pHsensitive nature a in a system.…”

Section: Introductionmentioning

confidence: 99%

Water Management within Tragacanth gum-g-polyitaconic Acid Hydrogels

Verma

2019

Adv. Mater. Lett.

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In our investigation, we have studied the interaction of the water molecules with the hydrophilic sites in itaconic acid grafted Tragacanth gum copolymer. The water existed in two different states within the hydrogel matrix. There is one fraction of water which has close interaction with functional groups and does not undergo freezing during cooling. Besides, this the other type of water undergoes thermal transitions and freezes at-50°C. The water management within the grafted matrix seems to be strongly governed by hydrophilicity, crosslinked density and functionality. The water uptake by the hydrogel increased significantly as the degree of grafting increased, in spite of the increasing crosslink density of the matrix. Results have been explained in terms of the carboxylic groups and their ionization which has an overriding influencing the hydrogel structure leading to a more amenable structure for the water diffusion.

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“…The chemical stimulus contains the pH value, chemical agents, and ions, and it responds to the interaction between the functional groups contained in the polymer chain and the solvent. The different response behaviors of hydrogels can be divided into the several types [ 11 ], like temperature-sensitive hydrogel [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ], pH-sensitive hydrogel [ 6 , 19 , 20 , 21 , 22 , 23 , 24 ], ionic strength hydrogel [ 19 ], glucose sensing hydrogel [ 25 ], and light-sensitive hydrogel [ 26 ]. A pH-sensitive hydrogel is a polymer hydrogel that can change in volume with changes in the environmental pH and ionic strength.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of pH Sensitive Chitosan/3-Glycidyloxypropyl Trimethoxysilane (GPTMS) Hydrogels by Sol-Gel Method

Weng

Huang

2020

Polymers

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pH responsive chitosan and 3-Glycidyloxypropyl trimethoxysilane (GPTMS) hydrogels were synthesized by the sol-gel crosslinking reaction. GPTMS was introduced to influence several behaviors of the chitosan hydrogels, such as the swelling ratio, mechanical properties, swelling thermodynamics, kinetics, and expansion mechanism. The functional groups of Chitosan/GPTMS hybrid hydrogels were verified by FT-IR spectrometer. Differential scanning calorimetry (DSC) and the thermogravimetric analysis (TGA) were used to analyzed the thermal behavior of water molecules, the expansion of thermodynamics, and the content of water molecules in the hydrogel. The results show that hydrogel consists of 50 wt.% GPTMS (CG50) and has good mechanical properties and sensitivity to pH response characteristics in the acidic/alkaline buffer solution. The increase of GPTMS content leads to the increase of hydrophobic groups in the hydrogel and causes the decrease of the overall water content and the freezing bond water content. When the hydrogels were immersed in acid solution, the interaction force parameter was smaller than that of DI-water and alkaline. It means that the interaction forces between hydrogel and water molecules are relatively strong. The swelling kinetics of hybrid hydrogels were investigated to inspect the swelling mechanism. The result is consistent with the Fisk’s diffusion mechanism, meaning that the rate of water penetration is adjustable. The biodegradable hydrogel (CG50) in this study has good environmental sensitivity and mechanical properties. It is suitable to be applied in the fields of drug release or biomedical technology.

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Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Cited by 25 publications

References 45 publications

Chitosan and Cellulose-Based Hydrogels for Wound Management

Chitosan and Cellulose-Based Hydrogels for Wound Management

Water Management within Tragacanth gum-g-polyitaconic Acid Hydrogels

Preparation and Characterization of pH Sensitive Chitosan/3-Glycidyloxypropyl Trimethoxysilane (GPTMS) Hydrogels by Sol-Gel Method

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