Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven, Sibusiso; Aderibigbe, Blessing Atim

doi:10.3390/ijms21249656

Cited by 168 publications

(90 citation statements)

References 152 publications

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“…Among biopolymers, chitosan is an attractive material, owing to its biocompatibility, antimicrobial activity, cheapness, and low toxicity. It has been widely used in the pharmaceutical industry (e.g., drug delivery carrier) [ 3 , 4 ], for biomedical applications (e.g., wound dressing) [ 5 , 6 ], the cosmetic industry (e.g., encapsulation of essential oils) [ 7 ], and the food packaging industry (e.g., antimicrobial film) [ 8 ]. Chitosan is a biopolymer in the category of polysaccharides, and comprises glucosamine and N-acetylglucosamine linked by β (1–4) bonds.…”

Section: Introductionmentioning

confidence: 99%

High Substitution Synthesis of Carboxymethyl Chitosan for Properties Improvement of Carboxymethyl Chitosan Films Depending on Particle Sizes

et al. 2021

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This study investigated the effect of chitosan particle sizes on the properties of carboxymethyl chitosan (CMCh) powders and films. Chitosan powders with different particle sizes (75, 125, 250, 450 and 850 µm) were used to synthesize the CMCh powders. The yield, degree of substitution (DS), and water solubility of the CMCh powders were then determined. The CMCh films prepared with CMCh based on chitosan with different particle sizes were fabricated by a solution casting technique. The water solubility, mechanical properties, and water vapor transmission rate (WVTR) of the CMCh films were measured. As the chitosan particle size decreased, the yield, DS, and water solubility of the synthesized CMCh powders increased. The increase in water solubility was due to an increase in the polarity of the CMCh powder, from a higher conversion of chitosan into CMCh. In addition, the higher conversion of chitosan was also related to a higher surface area in the substitution reaction provided by chitosan powder with a smaller particle size. As the particle size of chitosan decreased, the tensile strength, elongation at break, and WVTR of the CMCh films increased. This study demonstrated that a greater improvement in water solubility of the CMCh powders and films can be achieved by using chitosan powder with a smaller size.

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Section: Introductionmentioning

confidence: 99%

High Substitution Synthesis of Carboxymethyl Chitosan for Properties Improvement of Carboxymethyl Chitosan Films Depending on Particle Sizes

et al. 2021

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“…and natural polymers (such as hyaluronic acid/gelatin/pectin/cellulose/starch/dextran/konjac glucomannan etc.) [53,268,301,330,354,[362][363][364][365][366][367][368].…”

Section: Mps Hydrogelmentioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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“…Wounds are classified based on their time of healing and depth. The wounds are classified based on their duration of healing as acute and chronic wounds [ 12 ]. Acute wounds heal between a period of about 2 to 3 months [ 13 ].…”

Section: Classification Of Wounds and The Phases Of The Wound Healing Processmentioning

confidence: 99%

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Alven

Aderibigbe

2021

Polymers

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The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

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Chitosan and Cellulose-Based Hydrogels for Wound Management

Cited by 168 publications

References 152 publications

High Substitution Synthesis of Carboxymethyl Chitosan for Properties Improvement of Carboxymethyl Chitosan Films Depending on Particle Sizes

High Substitution Synthesis of Carboxymethyl Chitosan for Properties Improvement of Carboxymethyl Chitosan Films Depending on Particle Sizes

Marine Polysaccharides for Wound Dressings Application: An Overview

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

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