Traditionally used Thai medicinal plants: In vitro anti-inflammatory, anticancer and antioxidant activities

Siriwatanametanon, Nisarat; Fiebich, Bernd L.; Efferth, Thomas; Prieto, José M.; Heinrich, Michael

doi:10.1016/j.jep.2010.04.036

Cited by 167 publications

(104 citation statements)

References 70 publications

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“…In order to eliminate the influence of the moisture content of the plant, the yield of the extracts from B. alba leaves and T. terrestris seeds with different solvents were calculated depending on a dry weight basis and the yields were found to be high. Similar high yield from B. alba leaves has been reported with methanol in successive extraction with petroleum ether, ethyl acetate and methanol (Siriwatanametanon et al, 2010). Maximum yield percentage for T. terrestris seeds was obtained with aqueous extraction in a study using solvents such as petroleum ether, chloroform, acetone, alcohol and water (Asadulla 2011).…”

Section: Resultssupporting

confidence: 58%

“…Aqueous and methanol extracts from the dry leaves of Basella alba, a fast growing vegetable, probably originating from India (Bamidele et al, 2010), has been reported to possess active components that increase testosterone production in adult male rat testes during in vitro studies (Moundipa et al, 1999;Moundipa et al, 2005). This edible plant has also been described to possess nutritional values including androgenecity in traditional medicines of several countries (Siriwatanametanon et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Basella alba and Tribulus terrestris extracts for production of monosex Nile tilapia, Oreochromis niloticus

Ghosal¹,

Mukherjee²,

Hancz³

et al. 2015

J App Pharm Sci

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The present study was aimed to evaluate the efficacy of Basella alba and Tribulus terrestris for induction of masculinisation in Nile tilpia. B. alba leaves and T. terrestris seeds were extracted with water, ethanol, methanol, dichloromethane, hexane and successive methanol and mixed sex juveniles of Nile tilapia were subjected to dietary treatment with the extracts at the concentration of 0.5, 1.0 and 1.5 gm/kg feed. Treatment with both the plants showed no adverse effect on general fish health. There was no significant interaction effects (P>0.05) of solvent and concentration, and solvent and plant material for percentage of males. But, significant interaction effect (P<0.05) of concentration and plant material was observed for percentage of males. Also, there was significant interaction effect (P<0.05) of solvent, concentration and plant material for percentage of males. For dietary administration of B. alba leaves, the highest percentage of males (83.2±0.7) was obtained by treatment with ethanol extract at the concentration of 1.0 gm/kg feed. For all the solvents, the highest percentage of males was observed at the concentration of 1.0 gm/kg. But, in treatment with T. terrestris seeds, the highest percentage of males (88.9±1.1) was obtained with ethanol extract at the concentration of 1.5 gm/kg feed, which was also the highest percentage of males for all the treatment categories.

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Section: Resultssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Efficacy of Basella alba and Tribulus terrestris extracts for production of monosex Nile tilapia, Oreochromis niloticus

Ghosal¹,

Mukherjee²,

Hancz³

et al. 2015

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Siriwatanametanon et al (2010) reported that the methanol extract of the fresh leaves of C. trifolia has more potent DPPH free radical scavenging activity and strongly inhibits lipid peroxidation compared with Pouzolzia indica. A significant difference at p<0.05 was found between the fresh and dried leaf samples using water extraction.…”

Section: Discussionmentioning

confidence: 99%

“…The methanol extract of the leaves of C. trifolia showed the highest antioxidant activity because of the high amount of phenolics, such as cyanic acid and cyaniding (Siriwatanametanon et al 2010). Maisuthisakul et al (2007) reported that phenolic compounds and its derivatives, such as phenolic acids and tannins, are strongly correlated with antioxidant activity.…”

Section: Tpcmentioning

confidence: 99%

Effects of Different Drying Methods on the Antioxidant Activities of Leaves and Berries of Cayratia trifolia

Rabeta¹,

Lin²

2015

JSM

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This study aimed to assess the effects of fresh, thermal drying method (vacuum oven drying), and nonthermal drying method (freeze drying) on the antioxidant activities of leaves and berries of Kajian ini bertujuan menilai kesan kaedah pengeringan yang berbeza terhadap sampel segar, kaedah pengeringan terma (pengeringan ketuhar vakum) dan kaedah pengeringan tak terma (pengeringan beku) ke atas aktiviti antioksida daun dan beri Cayratia trifolia yang diukur melalui asai kuasa antioksidan penurunan ferik (FRAP) dan asai 1,1-difenil-1-pikrilhidrazil (DPPH). Jumlah kandungan fenolik (TPC) dan flavonoid (TFC

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“…Several inflammatory mediators, mainly bradykinin and metabolites of arachidonic acid, are potent pain-producing agents that can excite and sensitize nociceptive primary afferent neurons (Petho, Reeh, 2012). Several plant extracts have been studied for their anti-inflammatory properties, by using in vitro and in vivo models (Ojewole, 2006;Siriwatanametanon et al, 2010;Areej et al, 2013), and existing data suggest that L. divaricata may also have similar characteristics.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark

Rosa

Nardi

Januário

et al. 2014

Braz. J. Pharm. Sci.

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Luehea divaricata (Malvaceae) is a plant widely used for treatment of various inflammatory and infectious conditions; however few reports discuss its biological properties. The aim of this study was to evaluate the anti-inflammatory and analgesic effects as well as the macrophage activity in mice treated with the hydroalcoholic crude extract of L. divaricata (CLD). Thin layer chromatography revealed presence of epicathequin, stigmasterol, lupeol and α,β-amyrin in the extract. To evaluate the anti-inflammatory and analgesic activities, animals were subjected to paw edema induced by carrageenan test, writhing, formalin and capsaicin tests. Immunomodulatory activity was evaluated by adhesion and phagocytic capacity, lysosomal volume, and reactive oxygen species (ROS) production by peritoneal macrophages, after daily treatment with CLD for 15 days. CLD promoted reduction in paw edema (36.8% and 50.2%; p<0.05 at doses of 100 and 300 mg/kg, respectively), inhibited writhing behavior at the higher dose (64.4%, p<0.05), reduced formalin reactivity (81.2% and 91.6% at doses of 100 and 300 mg/kg, respectively, p<0.05), and reduced capsaicin reactivity by 63.9% (300 mg/kg). CLD (200 mg·kg -1 ·day -1 ) increased phagocytosis capacity of macrophages (~3 fold, p<0.05), neutral red uptake (~50%, p<0.001), and ROS production (~90%, p<0.001). These data suggest that CLD possesses anti-inflammatory, analgesic and immunostimulatory properties. Luehea divaricata (Malvaceae) é utilizada para o tratamento de várias condições patológicas, entretanto, há poucos relatos sobre sua bioatividade. O objetivo deste estudo foi avaliar o efeito anti-inflamatório e analgésico, bem como a atividade de macrófagos em camundongos tratados com extrato bruto hidroalcoólico (CLD) da planta. Cromatografia em camada delgada revelou a presença de epicatequina, estigmasterol, lupeol e α,β-amirina no material. Para avaliar a atividade anti-inflamatória e analgésica, animais foram submetidos a teste de edema de pata induzido por carragenana, teste de contorções, da formalina e da capsaicina. A atividade imunomodulatória foi avaliada pela capacidade de adesão e de fagocitose dos macrófagos, volume lisossômico e produção de espécies reativas de oxigênio (ROS), após tratamento diário com CLD por 15 dias. CLD promoveu redução do edema de pata (36,8% e 50,2%; 100 e 300 mg/kg, respectivamente; p<0,05), redução do número de contorções (64,4%; 300 mg/kg; p<0,05), redução da reatividade no teste da formalina (81,2% e 91,6%; 100 e 300 mg/kg, respectivamente; p<0,05), e no teste da capsaicina em 63,9% (300 mg/kg). CLD (200 mg·kg Uniterms: Luehea divaricata

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Traditionally used Thai medicinal plants: In vitro anti-inflammatory, anticancer and antioxidant activities

Abstract: This study provides in vitro evidence for the use of the Thai plants, most importantly Gynura pseudochina var. hispida, Oroxylum indicum and Muehlenbeckia platyclada as Thai anti-inflammatory remedies and these plants are now a priority for further phytochemical research.

Cited by 167 publications

References 70 publications

Efficacy of Basella alba and Tribulus terrestris extracts for production of monosex Nile tilapia, Oreochromis niloticus

Efficacy of Basella alba and Tribulus terrestris extracts for production of monosex Nile tilapia, Oreochromis niloticus

Effects of Different Drying Methods on the Antioxidant Activities of Leaves and Berries of Cayratia trifolia

Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark

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