Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review

Chen, Hua; Tian, Ting; Miao, Hua; Zhao, Ying-Yong

doi:10.1016/j.fitote.2016.06.009

Cited by 111 publications

(74 citation statements)

References 181 publications

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“…The mass spectrum exhibited a parent ion at m/z 308 consistent with the molecular formula C20H36O2. Previously, many species of Phellinus were reported as producing bioactive compounds like polysaccharides [22], flavones, triterpenes, aromatic acid, and amino acids [14]. These results were similar to those reported by Chinese scientists discovering active compounds from Phellinus species including palmitoleic acid, linoleic acid, oleic acid, hexadecanoic acid, and stearic acid [23].…”

Section: Gas Chromatography-mass Spectrometry Analysissupporting

confidence: 84%

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Structure Characterization and Evaluation Potential of Antimicrobial Extracts From Phellinus Linteus Against Skin Infectious Pathogens, Staphylococcus Epidermidis Atcc12228 and Propionibacterium Acnes Dmst14916

Techaoei

Eakwaropas

Jarmkom

et al. 2017

Int J Pharm Pharm Sci

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Objective: The objective of this study was to investigate the antimicrobial activity of Phellinus linteus against skin infectious pathogens, Staphylococcus epidermidis ATCC12228 and Propionibacterium acnes DMST 14916. Methods:Fungal fruiting bodies were extracted with 95% ethanol and ethyl acetate, and then, vaporized. The antimicrobial activities were determined by the disc diffusion method against Propionibacterium acnes DMST 14916 and Staphylococcus epidermidis ATCC12228 skin infectious pathogens. A minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) for those crude extracts were determined. Finally, the chemical profile of crude extract was determined by using thin layer chromatography and GC-MS. Results:The result demonstrated that the ethanolic extraction had more active fractions with an MIC of 0.5 mg/ml against the growth of Propionibacterium acnes DMST 14916 and Staphylococcus epidermidis ATCC12228 and also showed a minimum inhibitory concentration (MBC) at a concentration of 1.0 mg/ml, while ethyl acetate-based solvents failed to develop on TLC according to Retention factor (Rf) values of 0.71-0.76. The GC-MS was applied to investigate the chemical profile of crude extract of Phellinus linteus, revealing a component of hexadecanoic acid and 9, 12-octadecadienoic acid. Conclusion:Phellinus linteus fruiting body extracts have great potential as antimicrobial compounds against Propionibacterium acnes DMST 14916 and Staphylococcus epidermidis ATCC12228. Thus, they can be used in the treatment of infectious diseases caused by bacterial pathogens.

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Section: Gas Chromatography-mass Spectrometry Analysissupporting

confidence: 84%

“…All experiments were performed in triplicate. The results were represented by mean±standard deviation [14].…”

Section: Determination Of Minimum Inhibitory Concentration (Mic) and mentioning

confidence: 99%

Structure Characterization and Evaluation Potential of Antimicrobial Extracts From Phellinus Linteus Against Skin Infectious Pathogens, Staphylococcus Epidermidis Atcc12228 and Propionibacterium Acnes Dmst14916

Techaoei

Eakwaropas

Jarmkom

et al. 2017

Int J Pharm Pharm Sci

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show abstract

“…Many studies have reported that this mushroom exhibits various pharmacological effects on several ailments including tumors, diabetes, inflammation and obesity. 4 Experimental demonstrations of antitumor, 5 immunomodulatory, 6 anti-inflammatory 7 and antioxidant 8 activities of P. linteus have also been reported. Moreover, a large number of bioactive compounds have been isolated and extracted from this medicinal mushroom.…”

Section: Introductionmentioning

confidence: 98%

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Ph ellinus linteus and their absolute structure determination

et al. 2017

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“…In mycelia of PL, the content of protein, amino acid, total sugar, reducing sugar, polysaccharide and saturated fatty acid were more abundant as compared with the fruiting body (Chen et al, 2016). There are several literatures to reported that polysaccharides might play an important role in the activity of alleviating the myocardial IR injuries (Lu and Zhao, 2010; Zhang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The mycelial culture of PL was be found its polysaccharide might have effect on anti-inflammation, which was believed that it resulted from the structures of the high molecule weight could stimulate the reticulo-endothelial system (Song et al, 1995; Baker et al, 2008). Antioxidant such as hispidin was found in PLM (Chen et al, 2016). Hispidin was identified and could scavenge the free radicals (Lee and Yun, 2007; Jung et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation

Su¹,

Chu

Liao

et al. 2017

Front. Pharmacol.

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The incidence of myocardial ischemia-reperfusion (IR) injury is rapidly increasing around the world and this disease is a major contributor to global morbidity and mortality. It is known that regulation of programmed cell death including apoptosis and autophagy reduces the impact of myocardial IR injury. In this study, the cardioprotective effects and underlying mechanisms of Phellinus linteus (Berk. and Curt.) Teng, Hymenochaetaceae (PL), a type of medicinal mushroom, were examined in rats subjected to myocardial IR injury. The left main coronary artery of rats was ligated for 1 h and reperfused for 3 h. The arrhythmia levels were monitored during the entire process and the infarct size was evaluated after myocardial IR injury. Furthermore, the expression levels of proteins in apoptotic and autophagic pathways were observed. Pretreatment with PL mycelium (PLM) significantly reduced ventricular arrhythmia and mortality due to myocardial IR injury. PLM also significantly decreased myocardial infarct size and plasma lactate dehydrogenase level after myocardial IR injury. Moreover, PLM administration resulted in decreased caspase 3 and caspase 9 activation and increased Bcl-2/Bax ratio. Phosphorylation level of AMPK was elevated while mTOR level was reduced. Becline-1 and p62 levels decreased. These findings suggest that PLM is effective in protecting the myocardium against IR injury. The mechanism involves mediation through suppressed pro-apoptotic signaling and regulation of autophagic signaling, including stimulation of AMPK-dependent pathway and inhibition of beclin-1-dependent pathway, resulting in enhancement of protective autophagy and inhibition of excessive autophagy.

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Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review

Cited by 111 publications

References 181 publications

Structure Characterization and Evaluation Potential of Antimicrobial Extracts From Phellinus Linteus Against Skin Infectious Pathogens, Staphylococcus Epidermidis Atcc12228 and Propionibacterium Acnes Dmst14916

Structure Characterization and Evaluation Potential of Antimicrobial Extracts From Phellinus Linteus Against Skin Infectious Pathogens, Staphylococcus Epidermidis Atcc12228 and Propionibacterium Acnes Dmst14916

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Ph ellinus linteus and their absolute structure determination

Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation

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