γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Ph ellinus linteus and their absolute structure determination

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

“…To date, phytochemists have discovered 13 kinds of terpenoids from the mycelium of P. linteus with pharmacological activity [29,30,40,69]. It was reported that phellilane L ( 16 ), phellidene E ( 17 ), and (−)- trans -γ-monocyclofarnesol ( 18 ) exhibited antimicrobial activities against P. gingivalis [29,30]. In addition, atractylenolide I ( 19 ) was revealed to have antitumor activity [40].…”

“…An evaluation of the antimicrobial activity of phellilane L—isolated from the medicinal mushroom of P. linteus —against the periodontal bacteria Porphyromonas gingivalis had an MIC value of 278 μg/mL, lower than those of hinokitiol and triclosan that were used as positive controls (MIC of 25.0 and 3.13 μg/mL, respectively) in an antimicrobial assay [29]. γ-Ionylidene sesquiterpenoid from the mycelium of P. linteus was also shown to have antimicrobial activity against P. gingivalis [30]. The results revealed that (−)- trans -γ-monocyclofarnesol displayed significant antimicrobial activity against P. gingivalis with an MIC value of 5.9 μg/mL, while (+)-γ-ionylideneacetic acid and phellidene E had weak effects on the growth of P. gingivalis .…”

“…This role has been attributed to the biological activity of its various components, including polysaccharides, triterpenoids, polyphenols, and pyrans. Based on modern pharmacological studies, P. linteus is reported to have multifaceted biological activities, including anti-inflammatory [6,7,8,9,10,11,12,13,14], immunomodulatory [15,16,17,18,19], antioxidative [20,21,22,23,24,25,26], antimicrobial, and antiviral [27,28,29,30,31,32,33], as well as anticancer [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57], antidiabetic [58,59,60,61,62,63,64,65,66,67], hepatoprotective […”

Phellilane L, Sesquiterpene Metabolite of Phellinus linteus: Isolation, Structure Elucidation, and Asymmetric Total Synthesis

“…In the course of fractionation studies of cultured mycelia of P . linteus , a unique sesquiterpenoid, phellilane L ( 1 ), possessing a trans -cyclopropane ring was isolated (Figure ).…”

Study on the potential of Sanghuangporus sanghuang and its components as COVID-19 spike protein receptor binding domain inhibitors

“…Sanghuangporus sanghuang (SS) is a well-known medicinal polypore with a long history in China, Japan and Korea [19] . In previous pharmacological studies, SS has been demonstrated to have antitumor, antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective and immunomodulatory properties [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] . In this article, we investigated the impact of SS and its phenolic compounds on the protein expression of ACE2 and TMPRSS2 in vivo and in vitro.…”