A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

Abstract

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.

Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

“…Phellinus linteus is a famous medicinal mushroom that is widely used in Korea, Japan, China, and other Asian countries [ 22 ]. The various components including polyphenols, pyrans, polysaccharides, and triterpenoids play a significant role in improving the health condition [ 23 , 24 ]. Above all, Phellinus linteus mycelium (PLM) was used as medicines or healthy foods to treat several diseases such as infections, ulcer, cancer, and diabetes [ 25 ].…”

Safety evaluation of aqueous extracts of Sanghuangporus vaninii fruiting body in Sprague–Dawley rats

“…Sanghuangporus vaninii , a species of Sanghuang, is a traditional medicinal fungus. The fruiting body of S. vaninii can be used as a traditional Chinese medicine for daily health preservation and adjuvant therapy (Chen et al., 2019). However, its safety had not been assessed.…”

“…Chen et al. (2019) found that Sanghuang were mainly rich in polysaccharides, triterpenoids, and polyphenols. We found the aqueous extracts of S. vaninii fruiting body were rich in polysaccharides, nucleotides, and polyphenols (Figure 2), these polyphenols were representative compounds in Sanghuang (Chen et al., 2019).…”

“…Sanghuang have been used in Chinese traditional medicine for over 2000 years to treat various diseases. In recent years, modern pharmacological researches display that Sanghuang have multifunction such as anti‐carcinogenesis, anti‐inflammatory, anti‐oxidative, anti‐fungal, and immunomodulatory activities (Cai et al., 2019; Chen et al., 2019; Huo et al., 2020; Zhu & Cui, 2016). These active effects provided great potential for their application in medicinal and food industries.…”

Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice

“…FBR, a brown rice product, which is fermented with Aspergillus oryzae, also displayed a stronger suppressor activity against colonic carcinogenesis in DSS-treated Apc min mice [21], and Fisher 344 rats [22]. anti-inflammatory, anti-allergic, anti-angiogenic and antioxidant effects [31,32], and also effectively reduced the growth of human colon carcinoma cells [33][34][35]. Curcuma longa has also been used as a traditional herbal medicine due to its antiatherosclerotic, antidiabetic, antimutagenic, anticancer, and antioxidant effects [36].…”