Toxicological evaluation of jimson weed (Datura stramonium) seed

Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium

“…In our experiment, we observed a fairly significant increase in the absolute or relative weights of organs, especially the liver, in the alkaloid-treated group. Through this result, we noticed a significant similarity with the results of Duggan et al (1989) [9]. Where they have found in turn, a significant increase in the relative weight of the liver, brain, heart and spleen.…”

Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium

“…In our experiment, we observed a fairly significant increase in the absolute or relative weights of organs, especially the liver, in the alkaloid-treated group. Through this result, we noticed a significant similarity with the results of Duggan et al (1989) [9]. Where they have found in turn, a significant increase in the relative weight of the liver, brain, heart and spleen.…”

Mutagenicity of toxic weed seeds in the Ames test: jimson weed (Datura stramonium), velvetleaf (Abutilon theophrasti), morning glory (Ipomoea spp.), and sicklepod (Cassia obtusifolia)

“…The overall goal is to assess the possible significance of genotoxicity for the purpose of setting tolerance levels of the weed seeds in edible grain such as wheat and soybeans. This study complements previously described analytical, compositional, chemical, nutritional, and toxicological studies of some of these same seeds ; ; Dugan et al, 1989; Friedman and Levin, 1989; Friedman and Dao, 1990; .…”

“…Jimson weed seeds containing the toxic tropane alkaloids atropine and scopolamine occasionally contaminate commercial grain (Friedman and Levin, 1989). A recent 90- day feeding study in rats showed that jimson weed seeds produce adverse physiological effects, i.e., weight loss and changes in plasma enzymes, but no observable clastogenic (chromosome-damaging) activity in the bone marrow micronucleus test (Dugan et al, 1989). Negative micronucleus test results have also been observed with scopolamine given intraperitoneally to mice (data not shown).…”

Composition of jimson weed (Datura stramonium) seeds

“…They also found that alkali refining effectively removed atropine added to soybean oil. Subchronic 90-day toxicity studies with laboratory rats were conducted to establish safe levels of jimson weed seeds (Dugan et al, 1989). Dose-related adverse effects were observed at 0.5% or more in the diet.…”

Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium

“…In our experiment, we observed a fairly significant increase in the absolute or relative weights of organs, especially the liver, in the alkaloid-treated group. Through this result, we noticed a significant similarity with the results of Duggan et al (1989) [9]. Where they have found in turn, a significant increase in the relative weight of the liver, brain, heart and spleen.…”

Mutagenicity of toxic weed seeds in the Ames test: jimson weed (Datura stramonium), velvetleaf (Abutilon theophrasti), morning glory (Ipomoea spp.), and sicklepod (Cassia obtusifolia)

“…The overall goal is to assess the possible significance of genotoxicity for the purpose of setting tolerance levels of the weed seeds in edible grain such as wheat and soybeans. This study complements previously described analytical, compositional, chemical, nutritional, and toxicological studies of some of these same seeds ; ; Dugan et al, 1989; Friedman and Levin, 1989; Friedman and Dao, 1990; .…”

“…Jimson weed seeds containing the toxic tropane alkaloids atropine and scopolamine occasionally contaminate commercial grain (Friedman and Levin, 1989). A recent 90- day feeding study in rats showed that jimson weed seeds produce adverse physiological effects, i.e., weight loss and changes in plasma enzymes, but no observable clastogenic (chromosome-damaging) activity in the bone marrow micronucleus test (Dugan et al, 1989). Negative micronucleus test results have also been observed with scopolamine given intraperitoneally to mice (data not shown).…”

Composition of jimson weed (Datura stramonium) seeds

“…They also found that alkali refining effectively removed atropine added to soybean oil. Subchronic 90-day toxicity studies with laboratory rats were conducted to establish safe levels of jimson weed seeds (Dugan et al, 1989). Dose-related adverse effects were observed at 0.5% or more in the diet.…”

Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium

“…In our experiment, we observed a fairly significant increase in the absolute or relative weights of organs, especially the liver, in the alkaloid-treated group. Through this result, we noticed a significant similarity with the results of Duggan et al (1989) [9]. Where they have found in turn, a significant increase in the relative weight of the liver, brain, heart and spleen.…”

Mutagenicity of toxic weed seeds in the Ames test: jimson weed (Datura stramonium), velvetleaf (Abutilon theophrasti), morning glory (Ipomoea spp.), and sicklepod (Cassia obtusifolia)

“…The overall goal is to assess the possible significance of genotoxicity for the purpose of setting tolerance levels of the weed seeds in edible grain such as wheat and soybeans. This study complements previously described analytical, compositional, chemical, nutritional, and toxicological studies of some of these same seeds ; ; Dugan et al, 1989; Friedman and Levin, 1989; Friedman and Dao, 1990; .…”

“…Jimson weed seeds containing the toxic tropane alkaloids atropine and scopolamine occasionally contaminate commercial grain (Friedman and Levin, 1989). A recent 90- day feeding study in rats showed that jimson weed seeds produce adverse physiological effects, i.e., weight loss and changes in plasma enzymes, but no observable clastogenic (chromosome-damaging) activity in the bone marrow micronucleus test (Dugan et al, 1989). Negative micronucleus test results have also been observed with scopolamine given intraperitoneally to mice (data not shown).…”

Composition of jimson weed (Datura stramonium) seeds

“…They also found that alkali refining effectively removed atropine added to soybean oil. Subchronic 90-day toxicity studies with laboratory rats were conducted to establish safe levels of jimson weed seeds (Dugan et al, 1989). Dose-related adverse effects were observed at 0.5% or more in the diet.…”