Toxicological evaluation of an ethanolic extract from Chiococca alba roots

Gazda, Valeria E.; Gomes-Carneiro, Maria Regina; Barbi, Nancy S.; Paumgartten, Francisco José Roma

doi:10.1016/j.jep.2005.10.017

Cited by 19 publications

(14 citation statements)

References 11 publications

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“…A similar attenuation of body weight gain has been shown in rats given extracts of the root of Chicococca alba (Gazda et al, 2006) and stem bark of Stryphnodendron adstringens (Martius) Coville (L.) (Rebecca et al, 2002). Although, a decrease in body weight has been used as an indicator of adverse effects of drugs and chemicals (Raza et al, 2002;Teo et al, 2002), the suppression of body weight gain in this study may very well be as a result of decreased appetite (not ascertained in the present study) and thereby lower caloric intake by the animals, as has been shown for certain plants and their constituents, such as ephedrine, Ma Huang, and other active compounds in the genus Ephedra plants (Avula et al, 2006), and P57 from Hoodia gordonii (Avula et al, 2006), saponin from Korean red ginseng (Kim et al, 2005), and galegine from Verbesina encelioides (Lopez et al, 1996).…”

Section: Discussionsupporting

confidence: 74%

Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents

Rhiouani

El-Hilaly

Israili

et al. 2008

Journal of Ethnopharmacology

175

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Section: Discussionsupporting

confidence: 74%

Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents

Rhiouani

El-Hilaly

Israili

et al. 2008

Journal of Ethnopharmacology

175

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“…Other studies have also shown the weight reduction of rats after oral administration of the Chicococca alba extract [12] and Stryphnodendron adstringens [13].…”

Section: Effect Of Eear On the Weight Of Wistar Rats And Their Organsmentioning

confidence: 88%

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Guinnin

Klotoé

Atègbo

2017

Int J Pharm Pharm Sci

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Objective: Aristolochia albida Duch is frequently used by alternative medicine to treat some pathologies like hepatitis. Our main objective was to evaluate the acute oral toxicity of the ethanolic extract of this plant.Methods: Exploratory tests for acute oral toxicity are performed in vivo on Wistar albino rats in a limit test of 2000 mg/kg for 14 d in accordance with the OECD Guidelines 423. The clinical signs were observed every day, followed by measurement of body weight change, the haematological and biochemical examinations were executed and statistical analysis was performed. Results:The various clinical signs observed after administration and for 14 d were recorded and no mortality was observed. With the exception of white blood cells, mean cell volume and platelets with statistically significant difference in control (p<0.05), all the haematological parameters showed an insignificant statistical difference to the control ratio (p>0.05). For biochemical parameters, except blood glucose and total protein of control batches, which show a significant statistical difference after 14 d (p>0.05), all the biochemical parameters show the statistically insignificant difference for test and controls batches (p>0.05) as well as the weight variation of the animals. Conclusion:The ethanolic extract of the leaves of A. albida Duch (EEAr) had not toxic effect on the biochemical and hematological parameters studied at a dose of 2000 mg/kg. The lethal dose is therefore over 2000 mg/kg.

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“…This loss of weight can be explained by a reduction consumption, or by the possibility of dose/absorption interactions and the reduction of the quantity of food absorbed. Other studies have also shown the weight reduction of rats after oral administration of the Chicococca alba extract (Gazda et al, 2006) and Stryphnodendron adstringens (Rebecca et al, 2002). Organ body weight ratio is a useful index of swelling, atrophy or hypertrophy (Amresh et al, 2008).…”

Section: Discussionmentioning

confidence: 97%

Preliminary study of physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus in rats

Amina¹,

̈ne²,

Justin³

et al. 2018

J. Physiol. Pathophysiol.

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The present work aimed to investigate physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus (EEt(OH) P.a. Exploratory tests are performed in vivo on Wistar albino rats. Analysis of the variation in body weight at the level of the batch having received, and the control group showed a slight weight drop 7 d after treatment. This variation is not significant (p>0.05). The means relative organ weights show that there were no significant changes between control and treated groups (P ˃ 0.05). No obvious clinical signs (tremor, breathing rate, paralysis). Slightly greater differences were noted for WBC of the Control group and rats treaded with EEt(OH) P.a (5000 mg/kg b.w.) on day 14 after the administration. These differences were statistically significant (p<0.05). Similarly, the platelet count was slightly lower for the control rats compared to the rats treaded. The various biochemical parameters explored, Glucose, Bilirubin (BIL), Alanine amino transferase (ALT), Aspartate amino transferase (AST), Total protein (TP), alkaline phosphatase (ALP), urea (URE), creatinine (CR), Total bilirubin (TBIL) and Indirect bilirubin (IBIL), have informed us about the probable effects of the stem leaves of Phyllanthus amarus in the liver and kidney. There was no significant differences (p>0.05) in glucose, total protein, urea, creatinine levels between control and experiemental groups at 14 d. Total bilirubin (TBIL) and Indirect bilirubin (IBIL), however, were statistically significant (p<0.05). Other biochemical parameters such as ALT, AST, ALP show statistically insignificant difference (p>0.05) in test and control batch.

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Toxicological evaluation of an ethanolic extract from Chiococca alba roots

Cited by 19 publications

References 11 publications

Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents

Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Preliminary study of physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus in rats

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