Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Guinnin, Félix F.D.; Klotoé, Jean Robert; Atègbo, Jean Marc

doi:10.22159/ijpps.2017v9i7.16887

Cited by 7 publications

(8 citation statements)

References 16 publications

(17 reference statements)

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“…The biochemical findings (disturbance of biochemical parameters) are confirmed by those obtained from histological examination of kidney and liver. Moreover, our results were compared to those discussed in the chronic toxicity of A. manshuriensis in which the authors reported that the absence of any significant biochemical variation after feeding mice with organic extract for eight weeks [14–23]. Thus, the organic extract of A. manshuriensis was responsible for hepatic necrosis [19].…”

Section: Discussionmentioning

confidence: 81%

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Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence

Bourhia

Said

Chaanoun

et al. 2019

Journal of Toxicology

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Aristolochia baetica (A. baetica) is a wild species of Aristolochiaceae family; its roots are used by Moroccan people against cancer for many years ago. The objective of the study was to investigate the phytochemical screening, acute and subacute toxicity of A. baetica roots growing in the north of Morocco. Qualitative and quantitative analyses of A. baetica roots were performed using standard methods; the acute toxicity of the root extract of the studied plant was assessed in mice by gavage of single doses of 1, 2, and 4 g/kg body weight for 14 days; by the time the subacute toxicity was done using repeated doses 1, 1.5, and 2 g/kg/day for 28 days. Histological changes and biochemical parameters as markers of kidney and liver function were evaluated. The results of phytochemical screening showed the presence of polyphenols, tannins, alkaloids, flavonoids, saponins, and the absence of anthraquinones, sterols, and terpenes. The results of acute toxicity showed the absence of mortality and signs of toxicity in groups treated with 1 and 2 g/kg; however, the clinical signs of toxicity were important and the rate of mortality was estimated at 16 % in the group treated with 4 g/kg. The results of subacute toxicity showed several changes of serum parameters registered in groups treated with 1.5 and 2 g/kg/day, respectively. The results showed also the absence of histological injuries in groups treated with 1 and 1.5 g/kg/day; meanwhile, the histological alterations were remarkable in treated group with the highest dose administered of 2 g/kg/day. The outcome of this work showed that the roots’ extract of the studied plant was toxic in mice with repeated doses, but no toxic effect was observed with a single dose under 4g/kg.

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Section: Discussionmentioning

confidence: 81%

“…The filtrate was concentrated in a rotary vacuum evaporator. The crude extract reconstituted on a daily basis in distilled water for final concentrations required for oral administration [14].…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence

Bourhia

Said

Chaanoun

et al. 2019

Journal of Toxicology

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“…Acute oral toxicity is usually carried out in small groups of animal's gives information about the toxic profile of the plant extract. In any pharmaceutical preparation, acute oral toxicity studies are necessary to use in humans [14][15][16]. In the present study, the acute oral toxicity of ethanolic extract of A. grossus (L.f.) Goetgh.…”

Section: Discussionmentioning

confidence: 94%

Acute Oral Toxicity Study of Ethanolic Extract of Actinoscirpus Grossus (L.F.) Goetgh. And D.A. Simpson

Ganapathi

Holla

et al. 2018

Asian J Pharm Clin Res

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Objective: To study the acute oral toxicity of ethanolic extract of Actinoscirpus grossus (L.f.) Goetgh. and D.A. Simpson in Wistar albino rats.Methods: Ethanolic extract of the plant was assessed for single dose acute toxicity by employing Organisation for Economic Co-Operation and Development(OECD) guidelines 425 using Acute Oral Toxicity(AOT) software. The dosed (up or down as per the requirement) rats were observed for 14 days for general appearance, behavior, mortality, and necropsy. A total of 5 healthy female rats of body weight 225±25 g were used.Results: The test substance did not produce any mortality up to the dose of 2000 mg/kg per oral.Conclusion: Test substance is without any toxic potential even at the dose of 2000 mg/kg in animals and the Lethal Dose (LD50) value of A. grossus (L.f.) Goetgh. and D.A. Simpson was found to be more than 2000 mg/kg body weight.

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“…Thus, traditional medicine is a field that is still in a great demand for research [2]. The traditional medicine aslo safe and no toxic compared to conventional medicine [3,4].…”

Section: Introductionmentioning

confidence: 99%

Relaxation Activity of Tetanus (Leea Aequata L.) Leaf Ethanolic Extract on Guinea Pig Isolated Trachea

Ginting

Suwarso

Rumapea

et al. 2018

Asian J Pharm Clin Res

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Objective: The aim of this study is to determine the relaxation activity of the ethanolic extract of tetanus leaf (EETL) against contracting isolated guinea pig trachea induced by acetylcholine.Methods: Isolated trachea was equilibrated for 45 min until a stable condition in the Creb’s solution with a temperature of 37°C aerated with carbogen gas (O2:CO2=95%:5%). Test of the relaxation effect conducted after guinea pig trachea contracted with maximum acetylcholine concentration (EC80: 2.0449×10–3 mol) and then a cumulative with concentration of EETL (0.5 mg/mL–4 mg/mL) and concentration of atropine sulfate (6.95×10-6 mg/mL–2.08×10–2 mg/mL).Results: The results showed that EETL could lower the contraction smooth muscle of guinea pig trachea induced by acetylcholine. EETL at a concentration of 3.5 mg/mL had the ability to relax the muscle. It was not significantly different compared to that of atropine sulfate 6.95×10-3 mg/ mL (p>0.005).Conclusion: EETL has a relaxation effect on smooth muscle of guinea pig isolated trachea.

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Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Cited by 7 publications

References 16 publications

Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence

Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence

Acute Oral Toxicity Study of Ethanolic Extract of Actinoscirpus Grossus (L.F.) Goetgh. And D.A. Simpson

Relaxation Activity of Tetanus (Leea Aequata L.) Leaf Ethanolic Extract on Guinea Pig Isolated Trachea

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