Toxicological Approaches to the Toxic Metabolites of Fusaria

Sato, Norio; Ueno, Yoshio; Enomoto, Makoto

doi:10.1254/jjp.25.263

Cited by 67 publications

(17 citation statements)

References 11 publications

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“…Hayes and co-worker elegantly demonstrated that the T-2 toxin was suppressing hematopoiesis in the bone marrow and splenic red pulp of the mice, which resulted HCT values were significantly reduced. Another study reported that T-2 toxin administration decreased HCT values[7] and caused cellular damage to bone marrow[89] in cats. Another study, hematological toxicosis (thrombocytopenia and leucopenia) were observed in humans by ingestion of trichothecenes and the study showed that DON is the least myelotoxic and T-2 the most powerful toxin[10] and our study shows similar results where T-2 toxin proved as potential hematotoxic with a comparison of other mycotoxins.…”

Section: Discussionmentioning

confidence: 99%

Comparative hematoxicity of fusirium mycotoxin in experimental sprague-dawley rats

Chattopadhyay¹,

Upadhyay²,

Agnihotri³

et al. 2013

Toxicol Int

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Mycotoxins are fungal toxin and contaminated to human through food-stuffs. Hematological abnormality, mainly thrombocytopenia and leukopenia are induced after consumption of mycotoxin. Experiments were conducted to evaluate the hematotoxicity of trichothecenes mycotoxins in Sprague-Dawley rats. Hematological parameters viz. Hemoglobin, hematocrit, erythrocyte count (RBC), white blood cell count (WBC), lymphocytes, monocytes, neutrophils, eosinophils, basophils, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, mean platelet volume, plateletcrit and platelet distribution width were determined at 0, 6, 12 and 24 h after injection of 0.5 ml of T-2, Deoxynivalenol (DON), nivalenol, zearalenone, neosolaniol, ochratoxin-B mycotoxin equivalent to 1 × 10-3 μg/μl to Sprague-Dawley rats. Experiments showed that trichothecenes toxin produces severe hematological alternation. The reductions of RBC and WBC were observed in all Fusarium mycotoxins treated group. T-2 toxin group shows severe toxicity as compared to other mycotoxin treated group. DON is the least hematotoxicity and T-2 the most.

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Section: Discussionmentioning

confidence: 99%

Comparative hematoxicity of fusirium mycotoxin in experimental sprague-dawley rats

Chattopadhyay¹,

Upadhyay²,

Agnihotri³

et al. 2013

Toxicol Int

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“…Bone marrow was a target organ in guinea pigs (DeNicola et al, 1978). Lymphoid tissues and enteric mucosa were target organs in cats (Sato et al, 1975;Lutskye? al, 1978), and rats (Schoental et al 1979), and haemorrhages and oedema occurred in many organs.…”

Section: Histopathologymentioning

confidence: 99%

Mycotoxicosis produced in broiler chickens by multiple doses of either t‐2 toxin or diacetoxyscirpenol

et al. 1982

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SUMMARYT-2 toxin, a 12, 13-epoxytrichothecene mycotoxin, was given by crop gavage to 7-day-old male broiler chickens as 14 daily doses of 1.5, 2.0, 2.5, and 3.0 mg/kg body weight/day. Diacetoxyscirpenol, also an epoxytrichothecene, was given at doses of 2.5, 3.0,and 3.5 mg/kg/day. Some chickens became dehydrated and emaciated and died. In survivors, body weight and haematocrit were reduced, the feathers were malformed, and the beak and legs were pale yellow. At necropsy, the lymphoid organs were atrophic, bone marrow was pale red or yellow, the liver was discoloured yellow, and the crop mucosa was ulcerated.Microscopic lesions included necrosis and cell depletion in lymphocytic and haematopoietic tissues, and necrosis of hepatocytes, bile ductule epithelium, enteric mucosa, and germinal regions of feather barbs. Other hepatic lesions were fatty change of hepatocytes and hyperplasia of bile ductules. Thyroid follicles were small, contained pale colloid and had tall epithelial cells. T-2 toxin was more detrimental than diacetoxyscirpenol to lymphocytic and haematopoietic tissues.

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“…Toxic metabolites of Fusarium were responsible for a human disease outbreak (alimentary toxic aleukia) and have been implicated as the causative agent in many animal intoxica- tions (10). Trichothecenes such as T-2 toxin are cytostatic for unstimulated and mitogen-stimulated lymphocytes (11), fibroblasts (12), neoplastic cells such as HeLa cells (13), and transformed intestinal cells (14). In addition, Lefarge-Frayssinet et al (15) have shown that T-2 toxin induces severe damage to rat splenic cells in vitro.…”

Section: Introductionmentioning

confidence: 99%