Toxicity of hydrogen sulfide toward sulfate-reducing bacteria Desulfovibrio piger Vib-7

Kushkevych, Ivan; Đorđević, Đani; Vítězová, Monika

doi:10.1007/s00203-019-01625-z

Cited by 72 publications

(66 citation statements)

References 29 publications

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“…The presence of 5 mM H 2 S resulted in two times longer lag phase and generation time was eight times longer. The results are confirming H 2 S concentrations toxicity toward Desulfovibrio [30]. Other research showed that not only hydrogen sulfide and decreased level of LAB in the intestine can be the cause of the disease, but also low pH [31].…”

Section: Resultssupporting

confidence: 76%

Possible methods for evaluation of hydrogen sulfide toxicity against lactic acid bacteria

2019

Biointerface Res Appl Chem

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An integral part of the intestinal microbiota is undoubtedly formed by lactic acid bacteria (LAB). Their presence in the digestive tract is essential for its proper functioning. During inflammatory bowel disease, such as ulcerative colitis (UC), LAB occurrence is reduced while sulfate-reducing bacteria (SRB) occur widely in the intestine resulting in an increase of their metabolite, hydrogen sulfide. Inhibitory concentration and mechanism of action of hydrogen sulfide on LAB are not fully known yet. The aim of this paper is to find the proper testing methods for evaluation of the interaction between hydrogen sulfide and lactic acid bacteria, including minimal inhibitory concentration (MIC) determination. Spectrophotometric, colorimetric, agar plate methods and combination of these methods were tested. Thousands of people from all over the world are affected by inflammatory bowel disease every year. The gained results could help to understand and improve the stability of intestinal microbiome, improve the treatment of bowel inflammation diseases, or prevent bowel disease altogether

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Section: Resultssupporting

confidence: 76%

Possible methods for evaluation of hydrogen sulfide toxicity against lactic acid bacteria

2019

Biointerface Res Appl Chem

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“…This intestinal bacterial group of microorganisms produces hydrogen sulfide in the process of dissimilatory sulfate reduction process. The production of hydrogen sulfide in the high concentration can inhibit other intestinal microbiome including lactic acid bacteria of Lactobacillus genus [62] and also their producers, SRB [63].…”

Section: Enterococcal Impact On Inflammatory Bowel Diseases 71 Impacmentioning

confidence: 99%

The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease

2020

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AbstractThe constantly growing bacterial resistance against antibiotics is recently causing serious problems in the field of human and veterinary medicine as well as in agriculture. The mechanisms of resistance formation and its preventions are not well explored in most bacterial genera. The aim of this review is to analyse recent literature data on the principles of antibiotic resistance formation in bacteria of the Enterococcus genus. Furthermore, the habitat of the Enterococcus genus, its pathogenicity and pathogenicity factors, its epidemiology, genetic and molecular aspects of antibiotic resistance, and the relationship between these bacteria and bowel diseases are discussed. So-called VREfm – vancomycin resistant Enterococcus faecium and its currently rapidly growing resistance as well as the significance of these bacteria in nosocomial diseases is described.

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“…SRB influence the prevalence of IBD, but they are certainly not the only factor. The production of hydrogen sulfide affects the colon environment, but excessive amounts of hydrogen sulfide are also toxic for SRB [5].…”

Section: The Relationship Of Sulfate Reduction Pathways and Inflammatmentioning

confidence: 99%

“…In dissimilatory sulfate reduction (DSR), toxic hydrogen sulfide is produced, and in an assimilatory way, the terminal product is cysteine. One possible hypothesis of intestinal inflammation, including ulcerative colitis, is the effect of high concentrations of hydrogen sulfide on the intestinal epithelium [4][5][6][7][8][9][10]. In recent years, intestinal sulfate-reducing bacteria (SRB) (as a common part of the intestinal microbiome) have been associated with this disease [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria

Kushkevych

Cejnar

Treml

et al. 2020

Cells

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107

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Sulfate is present in foods, beverages, and drinking water. Its reduction and concentration in the gut depend on the intestinal microbiome activity, especially sulfate-reducing bacteria (SRB), which can be involved in inflammatory bowel disease (IBD). Assimilatory sulfate reduction (ASR) is present in all living organisms. In this process, sulfate is reduced to hydrogen sulfide and then included in cysteine and methionine biosynthesis. In contrast to assimilatory sulfate reduction, the dissimilatory process is typical for SRB. A terminal product of this metabolism pathway is hydrogen sulfide, which can be involved in gut inflammation and also causes problems in industries (due to corrosion effects). The aim of the review was to compare assimilatory and dissimilatory sulfate reduction (DSR). These processes occur in some species of intestinal bacteria (e.g., Escherichia and Desulfovibrio genera). The main attention was focused on the description of genes and their location in selected strains. Their coding expression of the enzymes is associated with anabolic processes in various intestinal bacteria. These analyzed recent advances can be important factors for proposing possibilities of metabolic pathway extension from hydrogen sulfide to cysteine in intestinal SRB. The switch from the DSR metabolic pathway to the ASR metabolic pathway is important since toxic sulfide is not produced as a final product.

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Toxicity of hydrogen sulfide toward sulfate-reducing bacteria Desulfovibrio piger Vib-7

Cited by 72 publications

References 29 publications

Possible methods for evaluation of hydrogen sulfide toxicity against lactic acid bacteria

Possible methods for evaluation of hydrogen sulfide toxicity against lactic acid bacteria

The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease

Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria

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