2020
DOI: 10.3390/cells9030698
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Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria

Abstract: Sulfate is present in foods, beverages, and drinking water. Its reduction and concentration in the gut depend on the intestinal microbiome activity, especially sulfate-reducing bacteria (SRB), which can be involved in inflammatory bowel disease (IBD). Assimilatory sulfate reduction (ASR) is present in all living organisms. In this process, sulfate is reduced to hydrogen sulfide and then included in cysteine and methionine biosynthesis. In contrast to assimilatory sulfate reduction, the dissimilatory process is… Show more

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Cited by 129 publications
(100 citation statements)
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“…Sulfate consumption, H 2 S production, lactate consumption and acetate accumulation play an important role in the environment, concerning the development of the intestinal bowel diseases [17,35,50,51]. Desulfovibrio spp.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Sulfate consumption, H 2 S production, lactate consumption and acetate accumulation play an important role in the environment, concerning the development of the intestinal bowel diseases [17,35,50,51]. Desulfovibrio spp.…”
Section: Discussionmentioning
confidence: 99%
“…are related to the occurrence and development of the IBD since it can be very often found in the intestines and feces of people and animals with this ailment. SRB use sulfate as a terminal electron acceptor [21,50,51]. These facts can lead us to the conclusion that sulfate present in different food commodities (some bread, soy flour, dried fruits, brassicas and sausages, as well as some beers, ciders and wines) [49] could be an important factor in the development of bowel disease.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, a reduction of sulfate became a dominant biological process in the water environment (oceans and deposits), resulting in sulfidic anoxic conditions from 2.5 to 0.6 billion years ago [54,55]. Currently, it is well known that SRB are able to colonize habitats that are different from the aquatic anaerobic environment where microorganisms have existed for a long time; in particular, the intestinal tract of animals (sea urchins, rodents, cows) and humans [56,57], where microorganisms need to adapt to new living conditions. The confirmation of this is that affinity data for substrates indicate that high affinity was shown for sulfite by SRB strains isolated from natural ecotopes, mainly in the soil environment.…”
Section: Discussionmentioning
confidence: 99%
“…This enzyme is also found in some phototrophic and chemotrophic sulfur oxidizers, where it is proposed to operate in the reverse direction (reverse sulfite reductase, rDSR) [54,70]. To confirm this, a recombinant Vib-7M strain was constructed that contained gene CysK coded O-acetyl-serine(thiol)lyase, which is an enzyme catalyzing the reaction of inorganic sulfide with O-acetyl-serine to form the S-containing amino acid l-cysteine [56]. Mutant strains are capable of higher speeds (1.5 times) using sulfate compared with the strains that are in the intestines of animals with colitis.…”
Section: Discussionmentioning
confidence: 99%
“…In connection to the observed increase of incidence of SRB in the oral cavity in patients with periodontitis, the possibility of toxic effects of H 2 S on oral epithelial cells is being considered, which could lead to the onset and further development of the disease [5][6][7]17]. H 2 S acts as an inhibitor of cellular cytochrome oxidase, and may also have a secondary effect, by breaking down disulfide bonds in proteins, which affects granulocytes and their function within the immune system [18,19].…”
Section: Introductionmentioning
confidence: 99%