Toxic Epidermal Necrolysis Following Allergic Contact Dermatitis Caused by Occupational Exposure to Ultraviolet-cured Inks

Abstract

Erythema multiforme is a relatively common skin disorder; the most common cause is herpes simplex infection, but topical sensitivities reportedly also provoke this reaction. We report here a case that progressed to toxic epidermal necrolysis due to contact with ultraviolet (UV)-cured inks. The diagnosis was confirmed by patch tests to acrylates in the UV-cured inks, histopathological studies of the lesions, and positive patch test to 1,6-hexanediol diacrylate.

Dermatitis de contacto ocupacional por tintas gráficas de curado ultravioleta (UV)

“…Se ha comunicado que el HDDA puede causar eritema similar al multiforme por contacto en trabajadores de imprenta con tintes UV curados 9 . El paciente también tenía sensibilización al tetrahidrofurfuril metilacrilato (THFMA), un acrilato multifuncional muy utilizado en adhesivos médicos, cementos odontológicos y óseos, y también empleado en la industria de impresiones gráficas 10 .…”

Ten years of contact allergy from acrylic compounds in an occupational dermatology clinic

“…Exposure to either 1,6‐HDDA or ethyleneglycol‐based acrylates could be found matching their allergic reactions (1,6‐HDDA, DEGDA, and TREGDA). There are several reports of 1,6‐HDDA sensitization in the printing industry 16,17 …”

Occupational toxic epidermal necrolysis associated with dalbergia cochinchinensis: a retrospective comparative study of eight cases in China

“…Other medication‐related factors that have been hypothesized to induce TEN include HIV, radiotherapy, and lupus erythematosus . Furthermore, there are some rare cases caused by occupational exposure to chemicals such as dendrimers, thiourea dioxide, and ultraviolet‐cured inks …”