Ten years of contact allergy from acrylic compounds in an occupational dermatology clinic

Abstract

Background Contact allergy from acrylic compounds is a "hot topic". Knowledge on the exact chemical composition of acrylic products is superficial. Aims To retrospectively describe patients with allergic reactions to acrylic compounds. Methods We included patients who had been tested with acrylate patch test series and displayed allergic reactions to at least one acrylic compound. Chemical analyses were often performed when safety data sheets of implicated products failed to reveal acrylic compounds to which the patient tested positive. Results In 2010–2019 a total of 55 patients met the inclusion criteria. Eight cases of allergic contact dermatitis were due to anaerobic sealants, seven to dental products, three to windscreen glues, seven to eyelash glues and/or nail products in the beauty sector, three to UV‐cured printing inks, two to paints/lacquers, and one to polyester resin system. The origin of these contact allergies was occupational with the exception of four beauty sector workers who had developed eyelid symptoms from eyelash extensions glued onto their own eyelashes. We invariably detected methacrylate monomers in 15 chemical analyses of 12 different anaerobic sealants. Conclusions Safety data sheets of anaerobic sealants often lack warnings for skin sensitization, although these products regularly contain sensitizing methacrylates.

Allergic contact dermatitis caused by dipropylene glycol diacrylate in the Omnipod® insulin pump*

“…As different products are used over time and the composition of the individual product can be altered, there is an increased risk of contracting more and more contact allergies throughout life. For individuals already sensitized there is a substantial risk of renewed allergen exposure and ACD elicitation, as acrylates are widespread in the environment in products such as ultraviolet‐cured printing inks and lacquers, 23 paints and varnishes 24 and glues used in MDs or other products 25–27 …”

“…For individuals already sensitized there is a substantial risk of renewed allergen exposure and ACD elicitation, as acrylates are widespread in the environment in products such as ultraviolet-cured printing inks and lacquers, 23 paints and varnishes 24 and glues used in MDs or other products. [25][26][27] There is an urgent need for primary prevention of MDrelated contact allergic reactions. The complex chemical nature of these devices underlines the importance of involving toxicologists with skin expertise in device development.…”

Allergic contact dermatitis caused by 2‐hydroxyethyl methacrylate and ethyl cyanoacrylate contained in cosmetic glues among hairdressers and beauticians who perform nail treatments and eyelash extension as well as hair extension applications: A systematic review

“…Another eight references were found by manually searching references (ie, backward and forward snowballing). A number of studies appeared to meet the inclusion criteria at first, [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] but they had to be omitted because they focused on a population that was inappropriate for this review. Case reports [38][39][40][41] and case series [42][43][44][45][46][47] were not included in the actual review, but compiled and extracted as supplemental information in case they were relevant in terms of including hairdressers and beauticians.…”

Outbreak of occupational allergic contact dermatitis from a smartphone screen protector glue

“…Occupational allergic contact dermatitis (ACD) from constituents of glues and adhesives have been described involving a variety of allergens such as acrylates and epoxy compounds [1][2][3][4][5][6][7] ; biocides (eg, 3-dibromo-2,4-dicyanobutane 8 ; N-methylol-chloroacetamide, chloromethylisothiazolinone/ methylisothiazolinone, 9 1,2-benzisothiazolin-3-one 10 ; colophony, 11 and so on). A variety of professionals has been described to develop ACD from glues such as beauticians, 3,6 cobblers and shoe manufacturers, 7,9 workers performing manual or automatized labeling, 8 carpenters, 9 machinists, 4 physiotherapists, 11 upholsterers, 11 and so on.…”