Occupational toxic epidermal necrolysis associated with dalbergia cochinchinensis: a retrospective comparative study of eight cases in China

Yang, Yue; Zhang, Zhen; Lu, Xiaonian; Zhu, Xiao‐Dong; Huang, Qiong; Liang, Jun; Xu, Jianhua

doi:10.1111/ijd.12784

Cited by 7 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the evaluation of combined therapies is more prone to errors than that of a single treatment. The results of this study suggest a reduction in mortality in patients treated with combined IVIG + CE therapy compared to those treated only with CE, 25,38,55,60‐62 IVIG alone 25 or just compared to the predicted mortality 41,63,64 . The EuroSCAR cohort study found a lower mortality in 40 patients treated with IVIG + CE compared with 35 patients treated with IVIG alone (mortality 18% vs 34%, respectively) 53 .…”

Section: Discussionmentioning

confidence: 64%

Systemic therapies for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN‐based systematic review and meta‐analysis

Torres‐Navarro

Briz‐Redón

Botella‐Estrada

2020

Acad Dermatol Venereol

View full text Add to dashboard Cite

BackgroundThe SCORTEN score is a specific predictor of mortality for patients with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). There is little evidence in support of the common immunomodulating therapies for SJS/TEN.ObjectivesTo systematically assess the effectiveness of several therapies for SJS/TEN through the SCORTEN score.MethodsDatabases were searched for original studies on the use of SCORTEN. Six meta‐analyses were carried out on patients with SJS/TEN who received supportive care only or in combination with immunomodulating drugs: corticosteroids, cyclosporine, etanercept, immunoglobulins or a combination of corticosteroids with immunoglobulins. A multivariate meta‐regression and a network meta‐analysis were also performed.ResultsOf 3893 studies identified, fifty‐two involving 2466 patients with SJS/TEN were preselected. Data from thirty‐eight of these studies (1827 patients) were finally pooled, and results [log(SMR)] from meta‐analyses were as follows: −0.13 (95% CI, −0.42,0.16) for corticosteroids, −0.39 (95% CI, −0.87,0.09) for immunoglobulins, 0.13 (95% CI, −0.15,0.40) for supportive treatment, −0.88 (95% CI, −1.47, −0.29) for cyclosporine, −0.95 (95% CI, −1.82, −0.07) for etanercept and − 0.56 (95% CI, −0.94, −0.19) for immunoglobulins plus corticosteroids. The meta‐regression analysis confirmed that cyclosporine and immunoglobulins plus corticosteroids were associated with less deaths than predicted by SCORTEN. In the network meta‐analysis, no treatment achieved a significant reduction in the SMR.LimitationsHeterogeneity and quality of the included studies.ConclusionsSome treatments for SJS/TEN show a better performance, but there is not sufficient evidence to recommend its widespread use in all patients.

show abstract

Section: Discussionmentioning

confidence: 64%

Systemic therapies for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN‐based systematic review and meta‐analysis

Torres‐Navarro

Briz‐Redón

Botella‐Estrada

2020

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…3 Obat penyebab tersering adalah obat antiinflamasi nonsteroid (OAINS), 4,5 golongan sulfa, 6,7 antibiotik laktam, antikonvulsan (misalnya karbamazepin, fenobarbital, dan fenitoin), antiretrovirus, agen kontras, alopurinol, dan lainlain. 8,9 Kerusakan jaringan pada NE terjadi akibat apoptosis sel keratinosit yang diinduksi oleh stimulus stres, kerusakan DNA, dan sitokin intraselular. 2,3 Insidens terjadinya SSJ diperkirakan 1-6,5 kasus per juta orang per tahun.…”

Section: Pendahuluanunclassified

Faktor Risiko Prediktor Bakteremia pada Pasien Nekrolisis Epidermal: Evidence-Based Case Report

Anindya¹,

Muhammad²,

Budianti³

2022

J. Kdokt Meditek

View full text Add to dashboard Cite

Nekrolisis epidermal (NE) yang terbagi atas Sindrom Stevens-Johnson (SSJ) dan nekrolisis epidermal toksik (NET) merupakan reaksi simpang obat berat dengan mortalitas tinggi. Penyebab kematian terbanyak pada NE adalah sepsis, namun gejala sepsis tidak spesifik pada NE dan hasil kultur darah membutuhkan waktu lama. Oleh karena itu penting mengetahui prediktor yang berpengaruh terhadap peningkatan risiko bakteremia pada pasien dengan NE. Evidence-based case report ini bertujuan mengetahui faktor prediktor terjadinya bakteremia pada pasien NE berdasarkan literatur. Pencarian artikel menggunakan basis data PubMed, Cochrane, dan Scopus yang relevan dengan pertanyaan klinis untuk kemudian ditelaah. Didapatkan dua artikel kohort yang sesuai. Studi Koh dkk. mendapatkan tiga prediktor yang berpengaruh terhadap kejadian bakteremia pada pasien NE; yaitu hemoglobin ≤ 10 g/dL (odds ratio [OR] 2,4; interval kepercayaan [IK] 95% 2,2-2,6), luas epidermolisis ≥ 10% (OR 14,3; IK 95% 13,4-15,2) dan penyakit komorbid kardiovaskular (OR 2,1; IK 95% 2,0-2,3). Studi De Prost dkk. mendapatkan tiga prediktor yaitu usia > 40 tahun (hazard ratio [HR] 2,5; IK 95% 1,35-4,63), leukosit > 10.000/mm3 (HR 1,9; IK 95% 0,96-3,61), serta LPB ≥ 30% (HR 2,5; IK 95% 1,13-5,47). Epidermolisis yang lebih luas merupakan faktor prediktor terjadinya bakteremia pada NE di kedua studi. Faktor risiko lainnya memerlukan penelitian lebih lanjut.

show abstract

“…Chemical constituents from the heartwood of D. cochinchinensis were isolated [7][8][9], e.g., 6,4 -dihydroxy-7-methoxyflavan [9]. From a clinical perspective, occupational toxic epidermal necrolysis was associated with D. cochinchinensis [10], and some compounds showed inhibitory activity towards 5α-dihydrotestosterone [9].The impact of isolated compounds of D. cochinchinensis to modulate an inflammatory response is rather unknown.…”

Section: Introductionmentioning

confidence: 99%

Heartwood of Dalbergia cochinchinensis: 4,7,2′-Trihydroxy-4′-methoxyisoflavanol and 6,4′-Dihydroxy-7-methoxyflavane Reduce Cytokine and Chemokine Expression In Vitro

et al. 2022

View full text Add to dashboard Cite

Dalbergia cochinchinensis has been widely used in traditional medicine because of its flavonoids; however, the impact of the flavonoids to modulate the inflammatory response to oral cells remains to be described. For this aim, we isolated 4,7,2’-trihydroxy-4’-methoxyisoflavanol (472T4MIF) and 6,4’-dihydroxy-7-methoxyflavane (64D7MF) from the heartwood of D.cochinchinensis and confirmed the chemical structure by nuclear magnetic resonance. We show here that both flavonoids are inhibitors of an inflammatory response of murine RAW 264.7 inflammatory macrophages stimulated by LPS. This is indicated by interleukin (IL)1, IL6, and chemokine CCL2 production besides the phosphorylation of p65. Consistently, in primary murine macrophages, both flavonoids decreased the inflammatory response by lowering LPS-induced IL1 and IL6 expression. To introduce oral cells, we have used human gingival fibroblasts and provoked the inflammatory response by exposing them to IL1β and TNFα. Under these conditions, 472T4MIF, but not 64D7MF, reduced the expression of chemokines CXCL1 and CXCL2. Taken together, we identified two flavonoids that can reduce the expression of cytokines and chemokines in macrophages and fibroblastic cells.

show abstract

Occupational toxic epidermal necrolysis associated with dalbergia cochinchinensis: a retrospective comparative study of eight cases in China

Abstract: Occupational TEN has a longer progression than TEN caused by drugs, and there is more difficulty in its treatment. Clinicians should pay attention to this disease. However, its mechanism and target therapy remain unclear.

Cited by 7 publications

References 18 publications

Systemic therapies for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN‐based systematic review and meta‐analysis

Systemic therapies for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN‐based systematic review and meta‐analysis

Faktor Risiko Prediktor Bakteremia pada Pasien Nekrolisis Epidermal: Evidence-Based Case Report

Heartwood of Dalbergia cochinchinensis: 4,7,2′-Trihydroxy-4′-methoxyisoflavanol and 6,4′-Dihydroxy-7-methoxyflavane Reduce Cytokine and Chemokine Expression In Vitro

Contact Info

Product

Resources

About