Toxic Effect of Babesiosis in Cattle and Chemotherapiotic Treatment in Egypt

Abstract

Babesia bigemina plays an important role in causing liver and kidney dysfunction in affected animals. The aim of this study evaluating the toxic effect of babesiosis on liver and kidney by measuring biochemical parameters and pathological tissue changes in infected animals with B. Bigemina and chose the best method of treatment. A total of 40 cattle age 1-3 years 30 were suffered from increase in temperatures, off food, Hemoglobin urea, red water from endemic area with babesia. Take sample from infected animals & examine it with microscopic examination found babesia bigemina and confirm by inoculation of heparinized blood from this animals in rats and found rats death at fifth day from infection and histopathological exam found babesia in piroplasma form in pathological tissue of rat's liver & kidney. The infected animals were divided into three groups each group 10 animals untreated group use as control positive and treated groups divided into two groups first group treated with imidocarb only and the second group use imidocarb and lincomcyn as antibiotic drug and compare between two groups by measuring liver& kidney function improvement and compare two groups with negative and positive group which method of treatment more effective in treatment of babesia & decrease toxic effect of babesia.

Direct blood PCR detection of Babesia bigemina and its effect on haematological and biochemical profile in crossbred cattle of eastern Haryana

“…Serum samples of B. bigemina infected crossbred cows showed significantly higher (p<0.01) values of ALT (78.83±8.95), AST (104.7±8.32), BUN (24.42±1.34), creatinine (1.93±0.1) and total bilirubin (1.42±0.06) than that of healthy control (Table 2). These results are in agreement with previous reports (Allen and Kuttler, 1981;Camacho, et al, 2005;Hamoda et al, 2014). The increase in enzymes activity and total bilirubin may attribute to severe anaemia that leads to hypoxic and toxic liver damages.…”

“…Substantial haemolysis in conjunction with hypoxia may lead to hepatic cell degeneration and glomerular dysfunction leading to increase in AST, ALT, BUN and creatinine. Significant (p<0.001) increase of both BUN and creatinine level observed in the present study is in accordance with the result obtained in earlier studies (Camacho et al, 2005;Hamoda et al, 2014). Comparison of lipid profile of healthy and infected groups revealed no significant difference (p>0.05) except at the level of HDL (p<0.05) ( Table 2).…”

Biochemical, Pathological and Molecular Studies on Babesiosis in Calves

“…The spleen showed extensive heamorrhage with necrosis of lymphoid tissue, neutrophilic infiltration with golden yellow to brown hemosiderine pigments. These results were in agreement with Bock et al, (2004), Schneider et al, (2011) and Hamoda et al, (2014). These results may be due to hemolysis of erythrocytes so lead to production of erythrocytes from bone marrow to compensate decrease in erythrocytes level.…”

Optimization of Conditions for Cultivation of Babesia bigemina -infected RBCs

“…Optimization of Conditions for Cultivation of Babesia bigemina -infected RBCs concurrent with previously reported study (Hamoda et al, 2014). Another study on cattle infected with B. bigemina showed a significant decrease (P<0.05) in HDL level and a non-significant decrease in the levels of other serum lipids (Ganguly et al, 2017).…”