Topical Glaucoma Therapy as a Risk Factor for Nasolacrimal Duct Obstruction

Seider, Nir; Miller, Benjamin; Beiran, Itzchak

doi:10.1016/j.ajo.2007.07.033

Cited by 41 publications

(20 citation statements)

References 14 publications

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“…Preoperative subclinical inflammation induced by previous exposure to long-term topical ocular glaucoma medication was felt to be the cause of this inflammation and higher surgical failure rate. Punctal stenosis is not uncommon from chronic exposure to topical ocular medication [40, 41]. In the NR, there are numerous cases of unilateral punctual stenosis occurring only on the side of the patient's monocular glaucoma.…”

Section: Hypothesis 5: Long-term Topical Ocular Medications With Tmentioning

confidence: 99%

The Role of Medications in Causing Dry Eye

Fraunfelder

Sciubba²,

Mathers

2012

Journal of Ophthalmology

101

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The purpose of this paper is to review the possible role of polypharmacy in causing dry eye disease (DED), reflecting the complex interactions and complications associated with the use of multiple systemic and topical ocular medications. The pharmacological, physiological, anatomical, and histological mechanisms causing dry mouth differ little from those causing dry eye. Oral polypharmacy is the most common cause of dry mouth, but has not been investigated as a cause of dry eye. Topical ocular polypharmacy has been shown to cause DED. Information on drugs that likely cause or aggravate DED and the controversial role of preservatives in topical ocular medications are examined. Systemic or topical ocular medications and preservatives used in topical ocular drugs may cause dry eye through the drug's therapeutic action, ocular surface effects, or preservatives, and the effects probably are additive. Long-term use of topical ocular medications, especially those containing preservatives such as BAK, may play an important role in DED and the role of polypharmacy needs further study. We review possible ways to decrease the risk of medication-related dry eye.

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Section: Hypothesis 5: Long-term Topical Ocular Medications With Tmentioning

confidence: 99%

The Role of Medications in Causing Dry Eye

Fraunfelder

Sciubba²,

Mathers

2012

Journal of Ophthalmology

101

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“…There are, however, a few reports on antihypertensive medications as a cause of NLDO or lacrimal canalicular obstruction. Seider et al [16] reported that chronic use of timolol-containing topical glaucoma therapy preparations in glaucoma patients is associated with an increased risk of developing NLDO. Kashkouli et al and McNab [17, 18] demonstrated that the punctum and canaliculus are the main anatomical sites of lacrimal drainage system obstruction associated with topical antihypertensive medications.…”

Section: Discussionmentioning

confidence: 99%

External Dacryocystorhinostomy: Characteristics and Surgical Outcomes in Patients with and without Previous Dacryocystitis

Rabina

Golan

Neudorfer

et al. 2013

Journal of Ophthalmology

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Objective. To compare pre- and postoperative characteristics and surgical success rates of patients with and without previous episodes of dacryocystitis, who underwent external dacryocystorhinostomy (DCR) for nasolacrimal duct obstruction (NLDO). Methods. The medical files of all patients who underwent external DCR between 2006 and 2011 in our institution were reviewed. The retrieved data of patients with and without previous episodes of dacryocystitis were compared. Surgical success was determined by postoperative followup of at least 6 months. Results. A total of 185 patients with NLDO underwent external DCR of whom 152 (100 females and 52 males, mean age 67 ± 15 years) met the inclusion criteria. Sixty had previous episodes of dacryocystitis and 92 did not. Left-side obstruction was more common than right-side obstruction among patients with previous episodes of dacryocystitis (48.3% versus 31.7%, resp., P = 0.031). Glaucoma patients were significantly more likely to develop dacryocystitis than patients without glaucoma (P = 0.002). The success rate of external DCR was 94.4% for patients with previous episodes of dacryocystitis and 86.7% for patients without (P = 0.337). Conclusions. The surgical outcomes of external DCR in patients with or without a previous episode of dacryocystitis were similar. Patients with glaucoma and NLDO had a significantly higher risk of developing dacryocystitis.

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“…Increased incidence of NLDO in patients being treated for glaucoma with eye drops containing timolol is also to be reported. As a matter of fact, the drug induces conjunctival inflammation and fibrosis, fostering conditions to nasolacrimal duct stenosis 4 .…”

Section: Introductionmentioning

confidence: 99%

Nasolacrimal duct obstruction: the relationship with nasal allergy

Passàli

Politi

Chen

et al. 2017

Romanian Journal of Rhinology

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Nasolacrimal duct obstruction (NLDO) is a common event in clinical practice. The authors, all members of the Italian Society of Rhinology, analysed 100 cases from different ENT Departments. The causes of NLDO, according to the etiology, can be divided into two classes: idiopathic primary acquired nasolacrimal duct obstruction and secondary. The aim of the study was to describe an association between the sign and symptoms of chronic rhinosinusitis and a complaint of epiphora.

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Topical Glaucoma Therapy as a Risk Factor for Nasolacrimal Duct Obstruction

Cited by 41 publications

References 14 publications

The Role of Medications in Causing Dry Eye

The Role of Medications in Causing Dry Eye

External Dacryocystorhinostomy: Characteristics and Surgical Outcomes in Patients with and without Previous Dacryocystitis

Nasolacrimal duct obstruction: the relationship with nasal allergy

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