: Cystic cervical lymph node metastasis is strongly associated with HPV-related tonsillar HNSCC: (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.

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Twenty-three neoplasms arising in major and minor salivary glands have been found to be composed of two types of myoepithelial cells-the plasmacytoid and spindle-cell form. Twelve of these were located within the parotid gland and the submandibular gland and intraoral minor salivary glands accounted for five each. A solitary example was found within the upper lip. Sixteen (70%) of the cases were of the spindle-cell type, four (17%) were composed of plasmacytoid cells, and three cases (13%) contained both cell forms in approximately equal quantity. Differences in behavior, recurrence rate, frequency, age of the patient, and location were not related to cell type. Ultrastructural analysis of selected cases showed myofilament aggregation patterns to vary between the two subtypes. Previously published cases confirmed by electron microscopy have been reviewed and compared with the 23 cases reported. Conservative surgical management is curative. Follow-up information on 16 cases is presented.Cancer 49:562-572, 1982.ERTAIN NEOPLASMS arising in major and minor C salivary glands are composed exclusively of cells of myoepithelial character. Well-documented is a dual cytologic appearance of myoepithelial cells within these tumors, some of which have a plasmacytoid appearance and others are spindle shaped. Tumors may be composed of one cell type or a mixture of both. Twenty-three cases are presented that we believe satisfy the criteria for and are representative of myoepitheliomas of salivary gland origin. Case selection was from the files of the Armed Forces Institute of Pathology covering a period from 1941-1979 and from the Long Island Jewish-Hillside Medical Center covering a period from [1974][1975][1976][1977][1978][1979]. Of all salivary gland tumor accessions in our series, myoepitheliomas accounted for less than 1% of the total. Acceptable cases were selected from those accessioned as myoepithelioma or mixed tumor with spindle-cell or plasmacytoid features. Treatment ranged from simple excision to exci-

No abstract

Oncocytic neoplasia of the parotid gland is a rare form of salivary gland disease with obscure etiology. The presence of multiple oncocytic morphologies in a single specimen is suggestive of transition between forms. Although oncocytic tumorigenesis secondary to acquired mitochondrial dysfunction is a plausible mechanism, few of these tumors actually harbor mtDNA alterations within the control region.

In addition, based upon our observations and review, we propose the notion that oral manifestations of Crohn's disease may be classified as an oligosymptomatic form of MRS.

Malignant odontogenic tumors are rare. They require a multidisciplinary team to determine proper treatment. Long-term surveillance is mandatory and is accomplished by routine physical examinations, along with serial radiographic imaging.

The results suggest that topical application of clobetasol in an adhesive denture paste is an effective drug for symptomatic oral vesiculo-erosive and/or ulcerative lesions.