Topical Delivery of Silver Nanoparticles Promotes Wound Healing

Abstract

Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.

Silver Nanoparticles as Real Topical Bullets for Wound Healing

“…91 Both of these chemokines promote monocyte accumulation, and macrophage inflammatory protein-1a is also a potent neutrophil chemoattractant in mice. 92 Tian et al 93 investigated the effect of silver nanoparticles in the inflammatory response at the wound site and observed that low levels of expression of trasforming growth factor b (TGF-b) coincided temporally with increased levels of interferon (IFN)-g until wound closure in animals treated with silver nanoparticles. As IFN-g has been demonstrated to be a potent antagonist of fibrogenesis through its ability to inhibit fibroblast proliferation and matrix production, its control of TGF-b production may play a role.…”

“…Besides a few mononuclear cells, VEGF expression is not found in other cell types in the wound. 96 Tian et al 93 suggest that keratinocytes in the wound are a major source of VEGF. As VEGF is highly specific for endothelial cells, it is likely to act in a paracrine manner on the sprouting capillaries of the wound edge and granulation tissue.…”

Silver nanoparticles reduce the apoptosis induced by tumor necrosis factor-α

“…It is widely held that nanomaterials induce cytokine signal transduction, leading to a range of in vitro studies focused on the advantages of AgNPs for providing an anti-inflammatory effect and their role in wound healing by lowering the concentrations of inflammatory mediators such as interleukin 1 and interferons [8, 9, and 10]. Several researchers have investigated the effects of AgNPs on the bacterial wall and how AgNPs inhibit bacterial growth [11, 12, and 13].…”

Production of putrescine-capped stable silver nanoparticle: its characterization and antibacterial activity against multidrug-resistant bacterial strains

“…Albeit, recently silver nanoparticles have been studied as biomarkers (Jain et al 2008;Schoefield et al 2006) for their localized surface plasmon resonance. They are mostly popular for their antimicrobial applications like, wound dressings (Tian et al 2007), water treatment (Lv et al 2009), fabrics and textile processing (Vo Ke Thanh and Phuong Phong 2009) and more recently in agronomy (Mandeh et al 2012;Abdi et al 2008;Saha et al 2015). Silver in their nano dimension has been reported to show immense antimicrobial activity without generation of any resistant variety strains.…”