Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling

Oryan, Ahmad; Mohammadalipour, Adel; Moshiri, Ali; Tabandeh, Mohammad Reza

doi:10.1097/sap.0000000000000239

Cited by 97 publications

(56 citation statements)

References 34 publications

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“…This property is cited in the literature in both topical and systemic applications; however, controversial results have been described. Some studies that investigated the topical use of Aloe Vera showed acceleration of wound healing (Choonhakarn et al, ; Eshghi et al, ; Heggers et al, ; Khorasani et al, ; Oryan et al, ; Rahmani et al, ), but in other studies wound healing was delayed (Schmidt and Greenspoon, ; Paulsen et al, ). The aim of this study was to evaluate the clinical and histopathological aspects of topical treatment with 0.5% Aloe Vera hydroalcoholic extract in oral wound healing in rats.…”

Section: Introductionmentioning

confidence: 99%

Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats

Coelho

Salvadori

Rados

et al. 2015

Phytotherapy Research

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The effect of topical application of Aloe Vera (Aloe barbadensis Miller) extract was assessed on the healing of rat oral wounds in an in vivo model using 72 male Wistar rats divided into three groups (n = 24): control, placebo and Aloe Vera (0.5% extract hydroalcoholic). Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool. The Aloe Vera and placebo group received two daily applications. The animals were sacrificed after 1, 5, 10 and 14 days. Clinical analysis (ulcer area and percentage of repair) and histopathological analysis (degree of re-epithelialization and inflammation) were performed. The comparison of the differences between scores based on group and experimental period, both in quantitative and semi-quantitative analyses, was performed using the Kruskal-Wallis test. The significance level was 5%. On day 1, all groups showed predominantly acute inflammatory infiltrate. On day 5, there was partial epithelialization and chronic inflammatory infiltrate. On the days 10 and 14 total repair of ulcers was observed. There was no significant difference between groups in the repair of mouth ulcers. It is concluded that treatment using Aloe Vera as an herbal formulation did not accelerate oral wound healing in rats.

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Section: Introductionmentioning

confidence: 99%

Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats

Coelho

Salvadori

Rados

et al. 2015

Phytotherapy Research

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“…Thus, topical application of L. inermis rapidly initiated inflammation by higher inflammatory cell infiltration and subsequently reduced the inflammatory phase compared to the control animals. Neutrophils, macrophages, and lymphocytes are infiltrated to the site of wound during inflammatory stage . On the other hand, the plant extracts prevent monocyte‐to‐macrophage differentiation .…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophils, macrophages, and lymphocytes are infiltrated to the site of wound during inflammatory stage. 19 On the other hand, the plant extracts prevent monocyte-to-macrophage differentiation. 20 Thus, L. inermis may decrease inflammatory phase by inhibiting monocyte-to-macrophage differentiation.…”

Section: Discussionmentioning

confidence: 99%

Topical administration of hydroethanolic extract of Lawsonia inermis (henna) accelerates excisional wound healing process by reducing tissue inflammation and amplifying glucose uptake

Daemi

Farahpour

Oryan

et al. 2019

The Kaohsiung J of Med Scie

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Several studies have reported the beneficial effects of Lawsonia inermis on wound healing, but the mechanism of action is still unknown. This study aimed to investigate the effectiveness of a new ointment formulation of hydroethanolic extract leaves of L. inermis on wound healing by gene expression of glucose transporter‐1 (Glut‐1) and insulin‐like growth factor I (Igf‐1) in Wistar rats. The animals were topically treated with different doses of L. inermis. An experimentally induced circular excisional wound model of 314 mm2 surface area was surgically created. The percentage of wound contraction and histopathological changes was assessed at different time points following wound induction. The expression of Glut‐1 and Igf‐1 was evaluated by reverse‐transcription PCR. Topical administration of L. inermis, dose dependently, shortened inflammatory phase, accelerated cellular proliferation, and enhanced wound contraction ratio. It also improved revascularization, collagen deposition, and re‐epithelialization rate and promoted intracytoplasmic carbohydrate storage (P < 0.05). Moreover, the mRNA levels of Igf‐1 and Glut‐1 were significantly higher in the L. inermis‐treated groups than the control group (P < 0.05). Topical administration of L. inermis promoted the healing process by reducing tissue inflammation and increasing glucose uptake, which was mediated by up‐regulating the expression of Igf‐1 and Glut‐1.

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“…insulin, phagocytosis, wound healing 1 | INTRODUCTION Wound healing is a complex process that consists of several phases including hemostasis and inflammation, proliferation or fibroplasia, and remodeling or maturation phases. 1,2 These wounds account for an increasingly significant economic burden as their prevalence is raising commensurate with an aging population, and an increase in obesity and diabetes. 3 Wound coverage is the best choice for small wound defects, but it is difficult to treat wounds such as diabetes, chronic, infection, burns, and large-area wound defects.…”

Section: Introductionmentioning

confidence: 99%

The molecular mechanism study of insulin in promoting wound healing under high‐glucose conditions

Wang

Bai

Jiang

et al. 2019

J of Cellular Biochemistry

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Background Wound healing is a complex process in bone development. The aim of this study was to explore the molecular mechanism study of insulin in promoting wound healing. Methods Firstly, the acute human monocyte leukemia cell lines were induced to differentiate into macrophages. Secondly, the porphyromonas gingivalis was applied to mix with the differentiated macrophages. Thirdly, the effect of different concentrations of insulin (0 ng/mL, 5 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL, and 1,000 ng/mL) on the phagocytosis of macrophages and production of reactive oxygen species was investigated. Depending on these experiments, the optimal insulin concentration was used to treat the macrophages at different time points (0 hours and 0.5 hours) to identify the differentially expressed mRNAs. Finally, functional analysis including gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein‐protein interaction (PPI) analysis was carried out to explore the biological function of these differentially expressed mRNAs. Results The test of phagocytosis function and production of reactive oxygen species showed that 200 ng/mL insulin treatment had a significant influence on antibacterial and production of reactive oxygen species. In RNA sequencing, a total of 415 (245 upregulated and 170 downregulated) differentially expressed mRNAs were identified between different time points. Two important signaling pathways including endocytosis and systemic lupus erythematosus were found in the KEGG enrichment analysis. In the PPI network, several hub proteins encoded by differentially expressed mRNA including ALB, HIP1R, RAB5A, HIST1H2BJ, HIST1H3G, and HIST1H2BO were identified. Conclusion Our work demonstrated that several differentially expressed mRNAs, such as EGR1, RAB34, ALB, HIP1R, RAB5A, HIST1H2BJ, HIST1H3G, and HIST1H2BO and two important signaling pathways including endocytosis and systemic lupus erythematosus may play important roles in the bone wound healing.

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Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling

Abstract: Topical application of A. vera improved the biochemical, morphological, and biomechanical characteristics of the healing cutaneous wounds in rats. This treatment option may be valuable in clinical practice.

Cited by 97 publications

References 34 publications

Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats

Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats

Topical administration of hydroethanolic extract of Lawsonia inermis (henna) accelerates excisional wound healing process by reducing tissue inflammation and amplifying glucose uptake

The molecular mechanism study of insulin in promoting wound healing under high‐glucose conditions

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