Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats

Abstract

The effect of topical application of Aloe Vera (Aloe barbadensis Miller) extract was assessed on the healing of rat oral wounds in an in vivo model using 72 male Wistar rats divided into three groups (n = 24): control, placebo and Aloe Vera (0.5% extract hydroalcoholic). Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool. The Aloe Vera and placebo group received two daily applications. The animals were sacrificed after 1, 5, 10 and 14 days. Clinical analysis (ulcer area and percentage of repair) and histopathological analysis (degree of re-epithelialization and inflammation) were performed. The comparison of the differences between scores based on group and experimental period, both in quantitative and semi-quantitative analyses, was performed using the Kruskal-Wallis test. The significance level was 5%. On day 1, all groups showed predominantly acute inflammatory infiltrate. On day 5, there was partial epithelialization and chronic inflammatory infiltrate. On the days 10 and 14 total repair of ulcers was observed. There was no significant difference between groups in the repair of mouth ulcers. It is concluded that treatment using Aloe Vera as an herbal formulation did not accelerate oral wound healing in rats.

Wound Healing with Botanicals: a Review and Future Perspectives

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Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation

“…Several studies have investigated the development of an ideal healing agent, although there is still no widely accepted or gold standard treatment for the management of oral ulcers. Different strategies are often combined and involve the use of corticosteroids (Oliveira et al, ), antibiotics (Teixeira et al, ), laser therapy (Wagner et al, ), and natural compound formulations (Coelho et al, ; Lim et al, ). However, these alternatives may not have significant benefits or can even lead to unwanted side effects (Coelho et al, ; Oliveira et al, ).…”

Main anthraquinone components in Aloe vera and their inhibitory effects on the formation of advanced glycation end-products

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