Thyroid Profile in Polycystic Ovarian Syndrome

Abstract

METHODS: All the USG proven cases of PCOS were subjected to investigations like FSH, LH, FBS, PPBS, Serum Insulin, TSH, Free T3, Free T4. After an overnight fasting, basal venous blood sample was taken. TFT including TSH, Free T3 and Free T4 was estimated using chemiluminescence method. According to this, TSH normal range was taken as 0.34-4.25 µIU/ml, Free T3 normal range was 2.4-4.2 pg/ml, Free T4 normal range was 0.8-1.7 ng/dl 137. TSH above 4.25 µIU/ml, Free T3 below 2.4 pg/ml and Free T4below 0.8 ng/dl was considered as overt hypothyroidism and high TSH with normal Free T3 and Free T4 are considered as subclinical hypothyroidism. RESULTS: The mean age of presentation was 27.28± 10.56 years. 78.57% of cases had menstrual complaints. 20.40 % 0f cases had Secondary Amenorrhoea, 56.12 % had Oligomenorrhoea, 2.04 % had Polymenorrhoea and 21.42% had normal menstrual cycles. 76.53 % of cases had Hyperandrogenism. 66.32 % had hirsuitism, out of which 69.23 % had mild hirsuitism, 29.23 % had moderate hirsuitism and 1.53 % had severe hirsuitism. 31.63% of cases had Acne.70 % of married cases had Infertility. Out of that 79.59 % had primary infertility and 20.40 % had secondary infertility. 38.77 % had infertility of duration 1-2 years, 51.02 % had infertility of 3-5 years and 10.20 % had infertility of >5 years. 64.28 % of cases had increased BMI (≥25 kg/m 2). The prevalence of hypothyroidism in PCOS was 13.26 %. Out of that 57.69 % had subclinical hypothyroidism and 42.30 % had overt hypothyroidism. 96.15 % of PCOS with hypothyroidism had menstrual irregularities like oligomenorrhoea and secondary Amenorrhoea. This association was found to be statistically significant. 96.15 % of PCOS with hypothyroidism had features of hyperandrogenism like acne and hirsuitism. This association was found to be statistically significant.84.61 % of PCOS with hypothyroidism had increased BMI (≥25 kg/m 2 .) This association was found to be statistically significant. PCOS and Hypothyroidism are closely related. CONCLUSION: There is increased prevalence of hypothyroidism in PCOS. The relationship between thyroid profile and PCOS is being tried to be explored more and thus the problems of PCOS can be solved to some more extent.

MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis

“…Four studies were excluded after reading the full text (18,19,20,21). Two of them investigated the impact of subclinical hypothyroidism on the metabolic profile of PCOS; however, they also have a control group of healthy women without PCOS which does not meet the eligibility criteria (18,20).…”

“…Two of them investigated the impact of subclinical hypothyroidism on the metabolic profile of PCOS; however, they also have a control group of healthy women without PCOS which does not meet the eligibility criteria (18,20). One more study assessed the influence of different parameters on PCOS but did not investigate the outcomes assessed in the present meta-analysis (21). In addition, the last one was excluded as it presents outcomes related to the correlation between PCOS and autoimmune markers (19).…”

Thyroid Disorders in Women with Polycystic Ovary Syndrome

“…Polycystic ovary syndrome (PCOS), the most common endocrinopathy of women is a complex disorder affecting approximately 5% -10% of women in their reproductive age and contributes to a major share of anovulatory infertility [1] [2]. PCOS is associated with 75% of anovulatory infertility.…”

“…PCOS is associated with 75% of anovulatory infertility. Even if they conceive, they can have very high pregnancy loss rates [2]. It can present in women of any ethnicity but more prevalent in South Asian women than in Caucasians [3].…”

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

“…However, there is increase in unbound fractions of oestrogens. 7 The metabolism of oestrogens is also altered with respect to oestradiol and estrone. The luteal phase defect with its inadequate levels of progesterone leads to excessive and irregular bleeding in presence of unopposed high levels of oestrogen causing menstrual irregularities, ovulatory dysfunction with luteal phase defect leading to infertility, recurrent pregnancy loss(RPL) and PCOS.…”