Thyroid Antibodies and Serum Thyrotropin in One Population

Notsu, Kazumi; Sakurami, Takehiko; Hirata, Masana; Goto, Yasuo; NOTE, Shinya; Notsu, Yoshitomo; Kunishi, Hiroyuki; Endo, Jiro

doi:10.1507/endocrine1927.59.3_230

Cited by 4 publications

(2 citation statements)

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“…This variation in reported prevalence seems to be attributable to the differences in the method of detection of autoantibodies, materials, and criteria of positive tests etc. Our results (MCHA:4.4% in males, 12.4% in females, TGHA: 1.9% in males, 5.0% in females) bear resemblance to the report of Notsu et al 21) (MCHA: 5.6% in males, 11.1 % in females, TGHA: 1.4% in males, 3.8% in females) who used similar methods to ours in detection of autoantibody and in criteria of positive tests. There seems to be no bias due to arbitrary allocation of sample numbers in our investigation because we corrected our data as described above.…”

Section: Discussionsupporting

confidence: 91%

The Prevalence of Antithyroid Autoantibodies in Normal Korean Population -Age, Sex Distribution and Its Relation to Thyroid Function-

Lee

Han

et al. 1986

Korean J Intern Med

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The prevalence of antithyroid autoantibodies and the relationship between the presence of autoantibodies and thyroid functions were studied in 848 apparently normal Korean adults with tanned red cell agglutination technique. Results are summarized as follows: 1) The prevalence of antimicrosimal antibody (MCHA) and antithyroglobulin antibody (TGHA) were 4.4% and 1.9% in 458 males, and 12.4% and 5.0% in 390 females, respectively. Both autoantibodies were more prevalent in female (p<0.001, p<0.01). 2) The age-specific prevalence of MCHA was 4.0% in their twenties, 10.1% in their thirties, 12.5% in their forties, 12.0% in their fifties, 8.3% over sixty, and those of TGHA were 2.0% in their twenties, 3.0% in their thirties, 7.0% in their forties, 4.2% in their fifties, 2.5% in subjects over sixty, respectively. Both showed maximal values around forty and fifty and tended to be lower thereafter. 3) Mean T3, T4 and TSH values of high titer group (⩾1:1002) (n=32) were 125 ± 20.6 ng/dl, 9.1 ± 1.7μg/dl and 4.0 ± 1.8 uU/ml, and those of low titer group (<1:1002) (n=44) were 134 ± 24.3 ng/dl, 9.6 ± 1.7 ug/dl and 3.2 ± 1.2 νU/ml. T3 was lower and TSH, higher in high titer group than in low titer group (p<0.05, p<0.05), and no significant difference was observed in T4 level (p<0.1). In conclusion, the prevalence of MCHA and TGHA were higher in apparently normal females than in males with their peaks around forty and fifty, being lower thereafter, and antithyroid autoantibody of high titer (⩾1:1002) was related to alteration of thyroid functions suggesting the existence of “subclinical autoimmune thyroiditis” state.

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Section: Discussionsupporting

confidence: 91%

The Prevalence of Antithyroid Autoantibodies in Normal Korean Population -Age, Sex Distribution and Its Relation to Thyroid Function-

Lee

Han

et al. 1986

Korean J Intern Med

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“…Antithyroid antibodies are considered to be age-dependent autoantibodies (Hooper et al, 1972). In our population survey, the incidence of MCHA gradually increased in those over 40 (Notsu et al, 1983). However, no individual in our survey had the three autoantibodies, ANA, ICA and MCHA.…”

Section: Discussionmentioning

confidence: 54%

Antinuclear antibodies in childhood diabetics.

et al. 1983

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Antinuclear antibodies (ANA) were detected both in type 1 diabetic children and in control subjects. The incidence of ANA in eighty of these diabetics was 16.3%, as determined using two different substrates, human pancreas and human peripheral leucocytes.The incidence and the patterns in the detection of ANA were the same. Four hundred and seventy-three children and one thousand one hundred and twenty-five adults served as the controls.The incidence of ANA in non-diabetic children was 0.8% and that in one adult population was 1.1%.Therefore, the incidence of ANA in childhood diabetics was significantly higher.We studied autoantibodies in childhood diabetics, in normal children and in one adult population.Pancreatic islet cell antibodies (ICA) were detected in 29 out of 80 type 1 diabetics (36.3%) in two out of 473 normal children (0.4%) and in six cases in one population (0.5%).Thyroid microsomal antibodies (MCHA) were detected in 9 out of 80 childhood diabetics and the incidence of MCHA in type 1 diabetics was significantly higher than in the controls.

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