Antinuclear antibodies in childhood diabetics.

Notsu, Kazumi; Nabeya, Noboru; Kuno, Shotaro; Sakurami, Takehiko

doi:10.1507/endocrj1954.30.469

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…ICA, CF-ICA and ANA were detected by indirect immunoflurescence using cryostat sections of human pancreas of blood type O and rat livers, respectively [11][12][13][14]. Human pancreas were obtained from patients with gastric or pancreatic cancer who received pancreatectomy.…”

Section: Methodsmentioning

confidence: 99%

Islet cell antibodies in the Japanese population and subjects with Type 1 (insulin-dependent) diabetes

Notsu¹,

Oka²,

NOTE³

et al. 1985

Diabetologia

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Islet cell antibodies were studied in 1,112 non-diabetic adults, 473 normal school children and 162 Type 1 (insulin-dependent) diabetic patients in a Japanese population. The prevalence of islet cell antibodies was 0.5%, 0.4% and 32%, respectively. Most islet cell antibodies positive subjects with Type 1 diabetes had short duration of the disease. No patients who had over 10 years from the onset had islet cell antibodies. Six non-diabetic adults with islet cell antibodies were followed for 4 years. Only one with Hashimoto's thyroiditis showed a diabetic pattern in her oral glucose tolerance test. However, none developed overt insulin-dependent diabetes until 1984. Two out of these six subjects continued to be positive for both islet cell antibodies and antithyroid antibodies or antinuclear antibodies. Islet cell antibodies in the remaining four patients disappeared during the second year. It is difficult to predict the onset of Type 1 diabetes by islet cell antibodies in non-diabetic individuals because they may be transient.

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Section: Methodsmentioning

confidence: 99%

Islet cell antibodies in the Japanese population and subjects with Type 1 (insulin-dependent) diabetes

Notsu¹,

Oka²,

NOTE³

et al. 1985

Diabetologia

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“…Similarly, the combination of HA with type 1 diabetes appears to be exceptional. ANA, in contrast, are found in about 15% of children at onset of type 1 diabetes, while are present in only 1% of normal controls (42,43). Despite the rarity of the coexistence of SLE and type 1 (autoimmune) diabetes, there is good evidence that, at least for loci within the MHC, some alleles confer susceptibility to both diseases.…”

Section: Discussionmentioning

confidence: 99%

Linkage Analysis of Systemic Lupus Erythematosus Induced in Diabetes-Prone Nonobese Diabetic Mice byMycobacterium bovis

Jordan

Silveira

Shepherd

et al. 2000

The Journal of Immunology

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Systemic lupus erythematosus induced by Mycobacterium bovis in diabetes-prone nonobese diabetic mice was mapped in a backcross to the BALB/c strain. The subphenotypes—hemolytic anemia, antinuclear autoantibodies, and glomerular immune complex deposition—did not cosegregate, and linkage analysis for each trait was performed independently. Hemolytic anemia mapped to two loci: Bah1 at the MHC on chromosome 17 and Bah2 on distal chromosome 16. Antinuclear autoantibodies mapped to three loci: Bana1 at the MHC on chromosome 17, Bana2 on chromosome 10, and Bana3 on distal chromosome 1. Glomerular immune complex deposition did not show significant linkage to any genomic region. Mapping of autoantibodies (Coombs’ or antinuclear autoantibodies) identified two loci: Babs1 at the MHC and Babs2 on distal chromosome 1. It has previously been reported that genes conferring susceptibility to different autoimmune diseases map nonrandomly to defined regions of the genome. One possible explanation for this clustering is that some alleles at loci within these regions confer susceptibility to multiple autoimmune diseases—the “common gene” hypothesis. With the exception of the H2, this study failed to provide direct support for the common gene hypothesis, because the loci identified as conferring susceptibility to systemic lupus erythematosus did not colocalize with those previously implicated in diabetes. However, three of the four regions identified had been previously implicated in other autoimmune diseases.

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“…Other examples of such non-organ-specific autoantibodies reported to be increased in type I diabetes include antibodies to DNA, lymphocytes, and albumin (23)(24)(25). The increased prevalence and elevated levels .i of anti-lg antibodies in type I diabetic subjects compared with normal controls may reflect the heightened immune responsiveness and high-responder status that underlie the basic autoimmune diathesis of type I diabetes and related disorders.…”

Section: Discussionmentioning

confidence: 99%

Circulating Anti-Immunoglobulin Antibodies in Recent-Onset Type I Diabetic Patients

Mario

Dotta²,

Crisá³

et al. 1988

Diabetes

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Human sera from 51 recent-onset insulin-dependent (type I) diabetic patients and 47 unrelated control subjects were screened for the possible presence of circulating factors reacting with several anti-pancreatic islet monoclonal antibodies (MoAb.ISL) in solid-phase radioimmunoassay methods (the original goal being the detection of anti-idiotypic islet cell antibodies and/or specific islet cell antigen-bearing immune complexes). MoAbs from the parental myeloma cell line and purified immunoglobulins (Igs) from different animal species were controls. Type I diabetic sera showed significantly increased binding to MoAb.ISL-coated wells compared with normal subjects (P less than .001). However, the same sera also tended to show a higher binding to the control (non-islet-related) MoAb. Sera from type I diabetic patients also reacted with horse, bovine, pig, rabbit, and goat IgG. Displacement of the binding has been obtained by F(ab')2 and/or Fc fragments of IgG. Evidence has been obtained regarding a similar reaction with human IgM. All the sera were negative when tested for rheumatoid factor by nephelometry. The circulating antibodies described have been proven to be different from islet cell autoantibodies. An anti-Ig antibody is thus present in the sera of recent-onset diabetic patients and represents an additional immunological phenomenon with possible physiopathological and clinical significance.

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Antinuclear antibodies in childhood diabetics.

Cited by 13 publications

References 17 publications

Islet cell antibodies in the Japanese population and subjects with Type 1 (insulin-dependent) diabetes

Islet cell antibodies in the Japanese population and subjects with Type 1 (insulin-dependent) diabetes

Linkage Analysis of Systemic Lupus Erythematosus Induced in Diabetes-Prone Nonobese Diabetic Mice byMycobacterium bovis

Circulating Anti-Immunoglobulin Antibodies in Recent-Onset Type I Diabetic Patients

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