Abstract:The prevalence of antithyroid autoantibodies and the relationship between the presence of autoantibodies and thyroid functions were studied in 848 apparently normal Korean adults with tanned red cell agglutination technique. Results are summarized as follows: 1) The prevalence of antimicrosimal antibody (MCHA) and antithyroglobulin antibody (TGHA) were 4.4% and 1.9% in 458 males, and 12.4% and 5.0% in 390 females, respectively. Both autoantibodies were more prevalent in female (p<0.001, p<0.01). 2) The age-spe… Show more
“…Another thyroid‐related autoantibody, Tg Ab, did not differ between NSV and SV. However, the Tg Ab positivity rate was higher in both groups than in the normal Korean population . The Tg Ab positivity rate was significantly higher in the late‐onset than in the early‐onset group.…”
Section: Discussionmentioning
confidence: 69%
“…This was the only one of the three tested autoantibodies that differed significantly; however, this difference was only just significant ( P = 0.048). The rate of TPO Ab positivity was previously shown to be higher in both types of vitiligo than in the normal population . Additional analyses according to subject characteristics other than the type of vitiligo revealed significantly higher rates of TPO Ab positivity in patients with late‐onset vitiligo and in female patients.…”
Section: Discussionmentioning
confidence: 80%
“…However, the Tg Ab positivity rate was higher in both groups than in the normal Korean population. 7 The Tg Ab positivity rate was significantly higher in the late-onset than in the early-onset group. Most patients with autoimmune thyroiditis have high serum concentrations of Tg Abs and TPO Abs.…”
Section: Discussionmentioning
confidence: 85%
“…The rate of TPO Ab positivity was previously shown to be higher in both types of vitiligo than in the normal population. 7 Additional analyses according to subject characteristics other than the type of vitiligo revealed significantly higher rates of TPO Ab positivity in patients with late-onset vitiligo and in female patients. TPO Ab, historically referred to as antimicrosomal antibody, is an antibody against TPO, which has an important role in the formation of thyroid hormones via iodination of tyrosine residues in thyroglobulin.…”
The positivity rates for the three autoantibodies showed differences according to age of onset and sex. The rates of Tg Ab and ANA positivity showed no significant differences according to clinical type, but the TPO Ab positivity rate was significantly different between SV and NSV. It appears likely that an autoimmune mechanism contributes to the pathogenesis of SV.
“…Another thyroid‐related autoantibody, Tg Ab, did not differ between NSV and SV. However, the Tg Ab positivity rate was higher in both groups than in the normal Korean population . The Tg Ab positivity rate was significantly higher in the late‐onset than in the early‐onset group.…”
Section: Discussionmentioning
confidence: 69%
“…This was the only one of the three tested autoantibodies that differed significantly; however, this difference was only just significant ( P = 0.048). The rate of TPO Ab positivity was previously shown to be higher in both types of vitiligo than in the normal population . Additional analyses according to subject characteristics other than the type of vitiligo revealed significantly higher rates of TPO Ab positivity in patients with late‐onset vitiligo and in female patients.…”
Section: Discussionmentioning
confidence: 80%
“…However, the Tg Ab positivity rate was higher in both groups than in the normal Korean population. 7 The Tg Ab positivity rate was significantly higher in the late-onset than in the early-onset group. Most patients with autoimmune thyroiditis have high serum concentrations of Tg Abs and TPO Abs.…”
Section: Discussionmentioning
confidence: 85%
“…The rate of TPO Ab positivity was previously shown to be higher in both types of vitiligo than in the normal population. 7 Additional analyses according to subject characteristics other than the type of vitiligo revealed significantly higher rates of TPO Ab positivity in patients with late-onset vitiligo and in female patients. TPO Ab, historically referred to as antimicrosomal antibody, is an antibody against TPO, which has an important role in the formation of thyroid hormones via iodination of tyrosine residues in thyroglobulin.…”
The positivity rates for the three autoantibodies showed differences according to age of onset and sex. The rates of Tg Ab and ANA positivity showed no significant differences according to clinical type, but the TPO Ab positivity rate was significantly different between SV and NSV. It appears likely that an autoimmune mechanism contributes to the pathogenesis of SV.
“…In a large American survey which for anti-TPO and anti-TG respectively, and women aged 30 to 39 had a prevalence of 12.6% and 13.6% [35] . An earlier Korean study by Lee et al on 390 women, the prevalence of anti-TG was 5% [36] . In a more recent survey, Amouzegar et al measured anti-TPO antibodies in 3390 normal women, and 541 (16%) were found positive [37] .…”
Excess iodine was prevalent in Korean children and adolescents, and it may be associated with SCH. Therefore, monitoring the iodine status and education on adequate intake are needed in iodine-rich areas.
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