Thyroid function in “Yusho” patients exposed to polychlorinated biphenyls (PCB)

Murai, K; Okamura, Ken; Tsuji, Hiroshi; Kajiwara, Eiji; Watanabe, Hidenori; Akagi, Kenzo; Fujishima, Masatoshi

doi:10.1016/s0013-9351(87)80226-8

Cited by 56 publications

(18 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies have shown strong inverse associations of PCBs with T4, in part related to decreased binding to tranthyretin [55], which accounts for binding of only 10% of T3 and T4 in adult humans. Other studies have not shown consistent associations with TBG [52,56,57]. …”

Section: Discussionmentioning

confidence: 85%

“…Thyroid associations with other forms of PCB exposure are not consistent, but tend to show positive, rather than negative, associations with peripheral thyroid hormones at higher levels of exposure [49-52]. Exposures from industrial sources, like the PCB and chlorinated naphthalene exposure in the current study, are often mixed with other exposures from dioxin like compounds and there is evidence that dioxin-like compounds have different effects than non-dioxin like PCBs that may have, in part, account for some of the differences seen among the studies, as noted in a cohort of occupationally exposed persons, whose exposure was primarily to dioxins, where workers had significantly higher levels of FT4 than the referent group [44].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant

Persky¹,

Piorkowski²,

Turyk³

et al. 2012

Environ Health

View full text Add to dashboard Cite

BackgroundStudies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive associations of polychlorinated biphenyls (PCBs) and inverse associations of selected steroid hormones with diabetes in postmenopausal women previously employed in a capacitor manufacturing plant.MethodsThis paper examines associations of PCBs with diabetes and endogenous hormones in 63 men previously employed at the same plant who in 1996 underwent surveys of their exposure and medical history and collection of bloods and urine for measurements of PCBs, lipids, liver function, hematologic markers and endogenous hormones.ResultsPCB exposure was positively associated with diabetes and age and inversely associated with thyroid stimulating hormone and triiodothyronine-uptake. History of diabetes was significantly related to total PCBs and all PCB functional groupings, but not to quarters worked and job score, after control for potential confounders. None of the exposures were related to insulin resistance (HOMA-IR) in non-diabetic men.ConclusionsAssociations of PCBs with specific endogenous hormones differ in some respects from previous findings in postmenopausal women employed at the capacitor plant. Results from this study, however, do confirm previous reports relating PCB exposure to diabetes and suggest that these associations are not mediated by measured endogenous hormones.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant

Persky¹,

Piorkowski²,

Turyk³

et al. 2012

Environ Health

View full text Add to dashboard Cite

show abstract

“…Murai et al (24) described an increase in serum T3 and T4 levels in adults 16 y after exposure to high levels of PCB and PCDF via food compared with nonexposed controls. Serum FT,, TSH, and T, binding globulin levels were not altered.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants

et al. 1994

View full text Add to dashboard Cite

Dioxins [polychlorinated dibenzo-p-dioxins (PCDD), dibenzofurans (PCDF)] and polychlorinated biphenyls (PCB) are potentially hazardous compounds. Animal studies have demonstrated that PCDD, PCDF, and PCB can alter thyroid hormone homeostasis. We investigated thyroid hormone levels in 105 mother-infant pairs. To estimate maternal and infant exposure, four nonplanar PCB congeners were measured in maternal plasma during the last month of pregnancy and in umbilical cord plasma. Seventeen PCDD and PCDF congeners, three planar PCB congeners, and 23 nonplanar PCB congeners were measured in human milk. Higher PCDD, PCDF, and PCB levels in human milk, expressed as toxic equivalents, correlated significantly with lower plasma levels of maternal total triiodothyronine and total thyroxine, and with higher plasma levels of TSH in the infants in the 2nd wk and 3rd mo after birth. Infants exposed to higher toxic equivalents levels had also lower plasma free thyroxine and total thy-PCDD and PCDF, summarized as dioxins, are tricyclic aromatic compounds. Because the number of chlorine atoms can vary between one and eight, there are potentially 75 different PCDD and 135 PCDF congeners. They are mainly formed as by-products during the synthesis of organochlorine chemicals and during the combustion of municipal and hazardous waste (1). PCB are a compilation of 209 possible congeners with different chlorine substitutions. Because of their unique physical properties and chemical stability, mixtures were used for diverse

show abstract

“…One of the most terrible human exposures to PCBs occurred through contaminated rice oil in the Fukuoka Prefecture, Japan in 1968. The disease, termed Yusho, was subject to much study and the studies showed that growth was affected to some extent (Aoki, 2001;Kuratsune, 1976;Masuda, 2001;Murai et al, 1987;Yoshimura, 1974). Research on growth of Yusho children and of children born to Yusho mothers has been summarized previously (Schell, 1991(Schell, , 1999Schell and Denham, 2003).…”

Section: Persistent Organic Pollutants: Polychlorinated Biphenylsmentioning

confidence: 99%

Effects of Pollution on Human Growth and Development: An Introduction

Schell

Gallo

Denham

et al. 2006

J Physiol Anthropol

View full text Add to dashboard Cite

Pollution is a worldwide problem and its potential to influence the physiology of human populations is great. Studies of human growth and development in relation to pollution have increased in number and quality since the mid-twentieth century. Many studies have found that some pollutants have detrimental effects on human growth, particularly prenatal growth. The heavy metal, lead, is commonly found in human populations and is related to smaller size at birth and studies have reported decrements that range up to about 200 grams. Noise stress from transportation sources also is related to reduced prenatal growth with somewhat smaller decrements reported. Studies of humans exposed to polychlorinated biphenyls, one of the persistent organic pollutants, have reduced size at birth, advanced sexual maturation and altered hormone levels related to thyroid regulation. Thus different pollutants exert effects through different physiological pathways. However, some studies have not observed these effects, which indicates that the situation is complex and requires further study with better study designs. Determining the effects of pollutants on human physiology and growth is difficult as it requires fairly large numbers of subjects who are not purposely exposed but for whom exposure can be measured. These effects of pollutants and the mechanisms of effect require further study to understand and, it is hoped, to blunt or block any detrimental effects on human health and well-being.

show abstract

Thyroid function in “Yusho” patients exposed to polychlorinated biphenyls (PCB)

Cited by 56 publications

References 17 publications

Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant

Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant

Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants

Effects of Pollution on Human Growth and Development: An Introduction

Contact Info

Product

Resources

About