Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats

Gelen, Volkan; Şengül, Emin; Gedikli, Semin; Gür, Cihan; Özkanlar, Seçkin

doi:10.1016/j.biopha.2017.02.057

Cited by 23 publications

(18 citation statements)

References 24 publications

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“…Gelen et al (24) reported that quercetin protected renal function in a rat model of obesity, while Yuksel et al (25) demonstrated that quercetin was able to reduce methotrexate-induced oxidative stress in rat models, suggesting that quercetin can alleviate methotrexate-induced renal damage and restore renal function. Elbe et al (26) revealed that quercetin is able to reduce ciprofloxacin-induced oxidative stress in rats, suggesting that quercetin may be an effective treatment for injuries.…”

Section: Discussionmentioning

confidence: 99%

Quercetin is able to alleviate TGF‑β‑induced fibrosis in renal tubular epithelial cells by suppressing miR‑21

Cao

Jianying

et al. 2018

Exp Ther Med

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Patients with chronic kidney disease (CKD) are characterized by a gradual loss of kidney function over time. A number of studies have indicated that tubule interstitial fibrosis (TIF) is associated with the occurrence and development of CKD. The aim of the present study was to investigate the effect of quercetin treatment on the fibrosis of renal tubular epithelial cells and to determine whether the anti-fibrotic effects of quercetin are achieved via microRNA (miR)-21. Human tubular epithelial HK-2 cells were cultured with transforming growth factor (TGF)-β to induce fibrosis and the expression of fibrotic markers collagen I, fibronectin, α-smooth muscle actin (SMA) and epithelial-cadherin were measured using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting. Cells were treated with 7.5, 15 or 30 mg/ml quercetin, following which fibrosis and miR-21 expression were evaluated. Quercetin-treated cells were transfected with miR-21 mimics and the expression of fibrotic markers was examined using RT-qPCR. Finally, the expression of fibrosis-associated miR-21 target genes, phosphatase and tensin homolog (PTEN) and TIMP Metallopeptidase Inhibitor 3 (TIMP3), was measured in cells treated with quercetin with or without miR-21 mimics using RT-qPCR, western blotting and immunocytochemistry. The results revealed that TGF-β treatment induced a significant increase in the expression of fibrotic markers in HK-2 cells, while quercetin treatment partially inhibited the fibrosis of HK-2 cells. Furthermore, quercetin treatment significantly inhibited TGF-β-induced miR-21 upregulation and transfection with miR-21 mimics reversed the anti-fibrotic effects of quercetin. Quercetin treatment markedly upregulated PTEN and TIMP3 expression, whereas transfection with miR-21 mimics reversed this effect. The results of the present study suggest that quercetin is able to alleviate TGF-β-induced fibrosis in HK-2 cells via suppressing the miR-21 and upregulating PTEN and TIMP3. Quercetin may have potential as an anti-fibrotic treatment for patients with renal fibrosis.

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Section: Discussionmentioning

confidence: 99%

Quercetin is able to alleviate TGF‑β‑induced fibrosis in renal tubular epithelial cells by suppressing miR‑21

Cao

Jianying

et al. 2018

Exp Ther Med

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“…Polyphenols are widely distributed in fruits, vegetables, herbs, seeds, cereals, honey and beverages (Hossen et al, 2017). Among the polyphenols present in foods, quercetin (QUE) and resveratrol (RES) have received increased interest because of their antioxidant and anti-inflammatory properties and evidence associating their intake with the prevention of non-communicable diseases, such as diabetes, obesity and cardiovascular disorders (Dolinsky et al, 2013; Gelen et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Polyphenols may exert health benefits at a local level when they act directly during passage through the gastrointestinal tract or at a systemic level after their absorption (Gelen et al, 2017). The digestion and absorption of dietary polyphenols are limited, being estimated that only 5–10% of total ingested polyphenols can be absorbed in the small intestine (Cueva et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of Quercetin and Resveratrol on in vitro Properties Related to the Functionality of Potentially Probiotic Lactobacillus Strains

et al. 2019

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The ability of probiotics to exert benefits on host has been associated with different physiological functionalities in these microorganisms, namely cell surface hydrophobicity, autoaggregation, coaggregation with pathogens, antagonistic activity against pathogens and ability to survive the exposure to gastrointestinal conditions. This study assessed the effects of different concentrations of quercetin (QUE) and resveratrol (RES) on the ability of six potentially probiotic Lactobacillus strains to tolerate different pH values and bile salt concentrations, to autoaggregate, coaggregate with and antagonize pathogens and survive the exposure to simulated gastrointestinal conditions. QUE and RES presented low inhibitory effects on all tested Lactobacillus strains, with minimum inhibitory concentration (MIC) ranging from 512 to >1024 μg/mL. In most cases, QUE and RES at all tested concentrations (i.e., MIC, 1/2 MIC, and 1/4 MIC) did not affect the tolerance of the Lactobacillus strains to acidic pH and bile salts. QUE increased cell surface hydrophobicity of most of the tested Lactobacillus strains and increases or decreases in cell surface hydrophobicity varied in the presence of different RES concentrations among some strains. QUE and RES increased the ability of tested Lactobacillus strains to autoaggregate and coaggregate with pathogens. QUE and RES did not negatively affect the antagonistic activity of the tested Lactobacillus strains against pathogens and did not decrease their survival rates when exposed to in vitro gastrointestinal conditions. In a few cases, the ability of some tested Lactobacillus strains to antagonize pathogens, as well as to survive specific steps of the in vitro digestion was increased by QUE and RES. QUE exerted overall better protective effects on the measured in vitro properties of tested Lactobacillus strains than RES, and L. fermentum and L. plantarum strains presented better responses when treated with QUE or RES. These results showed that probiotic Lactobacillus strains could present low susceptibility to QUE and RES. Combined use of QUE and RES with probiotic Lactobacillus could improve their functionalities on the host; however, the concentration of these polyphenols should be carefully selected to achieve the desirable effects and vary according to the selected probiotic strain.

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“…Unfortunately, as well as its beneficial antitumor effects, 5-FU also have the some toxicities which cardiotoxicity is one of these toxicities (23). The some flavonoids are widely used in researches for to prevent or treat the possible side effects of anticancer agents (24)(25)(26)(27)(28). The Q and Rutin compounds used for this purpose is found in the structure of many fruits and plants (18,19).…”

Section: Discussionmentioning

confidence: 99%

The effects of rutin and quercetin on ECG parameters in 5-FU-induced cardiotoxicity rat model

Gelen¹,

Şengül²,

Çınar³

2021

World J. Adv. Res. Rev.

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5‐fluorouracil (5-FU), a pyrimidine analogue anticarcinogenic agent, is widely used in the solid tumors treatment. Use of the 5-FU causes cardiotoxicity. Our aim in this study investigations effects of Quercetin and Rutin on ECG parameters in the 5-FU-induced cardiotoxicity in rats. In the present study used male rats. Rats were divided randomly to eight group. The control group was given intragastric corn oil for 14 days. The 5-FU group rats were given ig corn oil for 14 days and injected intraperitoneal the single dose of 5-FU(50 mg/kg) on the eleventh day. The Q50+5-FU and Q100+5-FU groups were given ig 50 mg/kg and 100 mg/kg Q for 14 days, respectively and these groups were injected single dose of 5-FU(50 mg/kg) on the 11th days of Q application. The group Q100 was Q(100 mg/kg-ig) for 14 days. The Rutin50+5-FU and Rutin100+5-FU groups were injected ig 50 mg/kg and 100 mg/kg of the Rutin for 14 days, respectively. These groups were injected single dose of 5-FU(50 mg/kg) in the 11th days of Rutin application. The Rutin 100 group was given Rutin(100 mg/kg-ig) for 14 days. In the end of experimental application recorded to ECGs of the rats. 5-FU administration rats were observed that it was caused sinus tachycardia and ST elevation. Also, in the 5-FU group QRS segment was shorter and the duration and amplitude of the P was different from other groups. In both doses of Q and Rutin were prevented these changes and our findings were seen the consistent with the literature.

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Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats

Cited by 23 publications

References 24 publications

Quercetin is able to alleviate TGF‑β‑induced fibrosis in renal tubular epithelial cells by suppressing miR‑21

Quercetin is able to alleviate TGF‑β‑induced fibrosis in renal tubular epithelial cells by suppressing miR‑21

Effects of Quercetin and Resveratrol on in vitro Properties Related to the Functionality of Potentially Probiotic Lactobacillus Strains

The effects of rutin and quercetin on ECG parameters in 5-FU-induced cardiotoxicity rat model

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