The effects of rutin and quercetin on ECG parameters in 5-FU-induced cardiotoxicity rat model

Abstract

5‐fluorouracil (5-FU), a pyrimidine analogue anticarcinogenic agent, is widely used in the solid tumors treatment. Use of the 5-FU causes cardiotoxicity. Our aim in this study investigations effects of Quercetin and Rutin on ECG parameters in the 5-FU-induced cardiotoxicity in rats. In the present study used male rats. Rats were divided randomly to eight group. The control group was given intragastric corn oil for 14 days. The 5-FU group rats were given ig corn oil for 14 days and injected intraperitoneal the single dose of 5-FU(50 mg/kg) on the eleventh day. The Q50+5-FU and Q100+5-FU groups were given ig 50 mg/kg and 100 mg/kg Q for 14 days, respectively and these groups were injected single dose of 5-FU(50 mg/kg) on the 11th days of Q application. The group Q100 was Q(100 mg/kg-ig) for 14 days. The Rutin50+5-FU and Rutin100+5-FU groups were injected ig 50 mg/kg and 100 mg/kg of the Rutin for 14 days, respectively. These groups were injected single dose of 5-FU(50 mg/kg) in the 11th days of Rutin application. The Rutin 100 group was given Rutin(100 mg/kg-ig) for 14 days. In the end of experimental application recorded to ECGs of the rats. 5-FU administration rats were observed that it was caused sinus tachycardia and ST elevation. Also, in the 5-FU group QRS segment was shorter and the duration and amplitude of the P was different from other groups. In both doses of Q and Rutin were prevented these changes and our findings were seen the consistent with the literature.

Cardioprotective effect of silymarin nanoemulsion on 5‐fluorouracil‐induced cardiotoxicity in rats

“…At both doses, rutin and quercetin (Q) reduced these changes, and our findings were in parallel with this study in which treatment with flavonoids such as Q and rutin could prevent these changes. [ 32 ] Also, 5‐FU (50 mg/kg, at weekly ips for six consecutive weeks) can reduce HR, prolong the RR interval duration, and increase ST. [ 33 ] In contrast, SIL (60 mg/kg, orally) has been found to reduce the harmful effects of doxorubicin (DOX) on myocardial function, including morphological and functional alterations in the heart, improve heart failure, and reduce ECG disorders, [ 34 ] which is consistent with our data.…”

Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation?

“…Various studies have shown that the use of some natural substances with anti-inflammatory properties can prevent inflammation-induced tissue damage [58][59][60][61][62][63][64][65]. Flavonoids are one of these natural ingredients.…”

Sensitive Marker Affected by All Systemic Abnormalities—troponine

“… 15 In the study of Gelen et al, in addition to severe myocardial damage, ECG changes were observed in rats given 5-FU. 16 Multitargeted kinase inhibitors targeting BCR-ABLs such as imatinib, bosutinib, and dasatinib can cause pleural and pericardial effusion and heart failure. 17 Taxifolin is protective against these effects.…”