The variability between individuals as a measure of senescence: A study of the number of eggs laid and the percentage of hatched eggs in the case of Drosophila melanogaster

David, Jean R.; Cohet, Y.; Fouillet, P.

doi:10.1016/0531-5565(75)90011-x

Cited by 51 publications

(35 citation statements)

References 28 publications

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“…With regular exposure to males, daily fecundity changes with age. It rapidly increases peaking at >60 eggs/day (range of 65-104 eggs/day in different genetic backgrounds) around 4-7 d pe followed by a progressive decline with fecundity levels half of peak levels 22 d-28 d pe and resulting in either infertility by 50 d pe 14,15,27,58,59 or a fecundity plateau. 60,61 Changes in fecundity over time have recently been modeled with more precision using 3 different recently wild-caught populations.…”

Section: Fecunditymentioning

confidence: 99%

“…A common marker of reproductive success in D. melanogaster is fecundity, which is experimentally measured as the number of eggs laid (e.g., 14,27,48,49,57 ). While a female's capacity to produce eggs is not the only determinant of reproductive success, it is critical, because it sets an upper-limit to fertility.…”

Section: Fecunditymentioning

confidence: 99%

“…2,[5][6][7] However, many laboratory studies characterizing female reproductive physiology or testing hypotheses related to sexual selection focus only on young females in their reproductive prime (e.g., [8][9][10][11][12][13] ) and/or allow both male and female age to increase concurrently. [14][15][16] Since male reproductive physiology also changes with increasing age, 17,18 controlling for male age in experiments helps distinguish the effects of female age, male age, and their interactions, on phenomena associated with reproductive senescence.…”

Section: Introductionmentioning

confidence: 99%

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The song of the old mother: Reproductive senescence in female drosophila

Miller

Obrik-Uloho

Phan

et al. 2014

Fly

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Among animals with multiple reproductive episodes, changes in adult condition over time can have profound effects on lifetime reproductive fitness and offspring performance. The changes in condition associated with senescence can be particularly acute for females who support reproductive processes from oogenesis through fertilization. The pomace fly Drosophila melanogaster is a well-established model system for exploring the physiology of reproduction and senescence. In this review, we describe how increasing maternal age in Drosophila affects reproductive fitness and offspring performance as well as the genetic foundation of these effects. Describing the processes underlying female reproductive senescence helps us understand diverse phenomena including population demographics, conditiondependent selection, sexual conflict, and transgenerational effects of maternal condition on offspring fitness. Understanding the genetic basis of reproductive senescence clarifies the nature of life-history trade-offs as well as potential ways to augment and/or limit female fertility in a variety of organisms.

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Section: Fecunditymentioning

confidence: 99%

Section: Fecunditymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The song of the old mother: Reproductive senescence in female drosophila

Miller

Obrik-Uloho

Phan

et al. 2014

Fly

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“…Here we determine how these types of factors and signal molecules change with age and affect GSC activity. In particular, we ask to what extent the well-described progressive decline of egg production with age (David et al ., 1975;Waskar et al ., 2005) is caused by stem cell aging in contrast to defects happening during later stages of oogenesis, from a daughter cystoblast to a mature egg.…”

Section: Introductionmentioning

confidence: 99%

Age‐related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila

et al. 2008

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SummaryAdult stem cells are important in replenishing aged cells to maintain tissue homeostasis. Aging in turn may exert profound effects on stem cell's regenerative potential, but to date the mechanisms of such stem cell aging are poorly understood, and it is not clear to what extent stem cell aging contributes to tissue or organ aging. Here we show in female Drosophila that germline stem cell (GSC) division rate progressively declines with age, which is accompanied by reduced decapentaplegic ( dpp ) niche signaling pathway activation within GSCs. Egg production also rapidly declines with age, which is accompanied by both decreased stem cell division and increased incidence of cell death of developing eggs, especially in the oldest females. Genetically increasing dpp expression delays GSC activity decline and transiently increases egg production. We conclude that age-related decline of reproduction is caused by both decreased GSC activity and increased incidence of cell death during oogenesis, while decreased GSC activity is attributed to declined signaling from the regulatory niche. We suggest that niche functional decay may be an important mechanism for stem cell aging and system failure.

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“…In our study standard drosophila 46.0 ± 1.57 N, total number of individuals: C, control; Max., maximum; SE, standard error; SD, standard deviation; w,water extract, e,ethanol extract; p, probability levels between groups; *the mean difference is not significant at the 0.001 level. medium (SDM) was used instead of different types of food, which might affect longevity (David et al, 1975). Maternal age is known to be an important factor on longevity of offspring (Sorensen & Loeschcke, 2002).…”

Section: Discussionmentioning

confidence: 99%