Extended longevity of<i>Drosophila melanogaster</i>by water and ethanol extracts of<i>Stachys lavandulifolia</i>

Altun, Deniz; Ayar, Arif; Uysal, Handan; Kara, Aslı; Unal, Elif Leman

doi:10.3109/13880201003789424

Cited by 9 publications

(7 citation statements)

References 32 publications

(29 reference statements)

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“…The increase of the mean lifespan by 12 days is a robust effect, which has possibly not been shown so far in D. melanogaster by a single natural compound. Only some plant extracts including Rhodiola rosea , Stachyus lavandulifolia , and various herbal extracts have been shown to prolong lifespan to a similar extent. Currently, caloric restriction is the only well‐established intervention to effectively augment lifespan in most organisms including yeast, various invertebrate models, laboratory rodents, and primates .…”

Section: Discussionmentioning

confidence: 99%

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Staats¹,

Rimbach²,

Künstner

et al. 2018

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Staats¹,

Rimbach²,

Künstner

et al. 2018

Molecular Nutrition Food Res

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“…Ursolic and oleanolic acids were described as phytochemicals with significant pro-longevity action. The treatment with 25–50 µM ursolic acid and plant extracts reached with this compound increased the mean and maximum lifespan of C. elegans and D. melanogaster up to 30% [ 250 , 251 , 252 , 253 ]. Oleanolic acid at the 100–600 μM concentration extends the mean lifespan of nematodes by 10–20% [ 254 ].…”

Section: Terpenoids As Potential Geroprotectorsmentioning

confidence: 99%

“…Oleanolic acid at the 100–600 μM concentration extends the mean lifespan of nematodes by 10–20% [ 254 ]. Stachys lavandulifolia extracts that have betulin, betulinic acid, oleanolic acid, and ursolic acid among constituents sufficiently extend the Drosophila life [ 253 ].…”

Section: Terpenoids As Potential Geroprotectorsmentioning

confidence: 99%

Terpenoids as Potential Geroprotectors

et al. 2020

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Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases.

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“…Effects of aqueous and ethanolic extracts of Stachyslavan dulifolia has been studied on the longevity of D. melanogaster [9]. Similarly, lifespan studies have been made in D. melanogaster using different extracts of many herbal plants namely Emblica officinalis, Curcuma longa, Triticum aestivum,, Aloe vera [10][11][12][13][14].The supplementation of cocoa extends the life span of D. melanogaster under different oxidative stress conditions [15].…”

Section: * Corresponding Authormentioning

confidence: 99%

Asparagus racemosus extract increases the life span in Drosophila melanogaster

Kumar¹,

Prasanna²,

Ashadevi³

2015

J App Biol Biotech

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Free radicals and oxidative stress are recognized as important factors in the biology of aging as well as in many age-related diseases. Dietary antioxidant plays a potential role in the reduction of age-related diseases. Many medicinal plants are rich source of antioxidants and promote longevity. Drosophila is a suitable animal model to study ageing and oxidative study. This study evaluated the antioxidant property of Asparagus racemosus on longevity and G6PD activity in Drosophila melanogaster. The analyses were carried out in stress and non stress conditions. Longevity increased almost by 29% at low concentration and 41% at high concentration in extract supplemented flies. G6PD level was significantly increased in extract supplemented larval stages than adults. The antioxidant property of Asparagus racemosus increases the larval G6PD activity thus; it extends the lifespan in adults.Abbreviation A. racemosus Asparagus racemosus, ACR Acrylamide, OS Oxidative stress, G6PD Glucose 6 Phosphate Dehydrogenase.

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Extended longevity ofDrosophila melanogasterby water and ethanol extracts ofStachys lavandulifolia

Cited by 9 publications

References 32 publications

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Terpenoids as Potential Geroprotectors

Asparagus racemosus extract increases the life span in Drosophila melanogaster

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