The value of the bulbocavernosus reflex and pudendal nerve somatosensory evoked potentials in distinguishing between multiple system atrophy and Parkinson's disease at an early stage

Cai, Zuren; Niu, Xiaoting; Pan, Jie; Ni, Peiqi; Wang, X.; Shao, Baiqi

doi:10.1111/ane.12710

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…Thus, abnormal pudendal nerve somatosensory evoked potentials mainly reflect possible central and peripheral afferent neuropathy. Somatosensory evoked potentials of the pudendal nerves combined with the bulbocavernosus muscle reflex have localized and qualitative diagnostic significance for neurological lesions [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

2022

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Objective. To explore the diagnostic value of bulbocavernosus muscle reflex and pudendal somatosensory evoked potentials for diabetic neurogenic bladder. Methods. From January 2021 to December 2021, 104 patients with type 2 diabetes mellitus admitted to the hospital were recruited, with 57 allocated to the case group and 47 to the control group. Outcome measures included bulbocavernosus muscle response, pudendal somatosensory evoked potentials, and bladder residual urine volume. The connection of bulbocavernosus muscle response and pudendal somatosensory evoked potentials with bladder residual urine volume was investigated using the Pearson analysis. Results. In both males and females, the latency of the left and right bulbocavernosus muscle reflexes in the case group was longer than in the control group, but the difference was not statistically significant ( P > 0.05 ), and the wave amplitude of the left and right bulbocavernosus muscle reflexes was significantly smaller than that of the control group ( P < 0.05 ). The diabetic neurogenic bladder was associated with a significantly longer latency and a smaller wave amplitude of pudendal somatosensory evoked potentials versus without neurogenic bladder ( P < 0.05 ). Patients with a diabetic neurogenic bladder had more residual bladder urine volume versus those without ( P < 0.05 ). Bladder residual urine volume was significantly positively correlated with bulbocavernosus muscle reflex and pudendal somatosensory evoked potential latency and negatively correlated with wave amplitude ( P < 0.05 ). Conclusion. The bulbocavernosus muscle reflex and pudendal somatosensory evoked potentials demonstrate great potential as adjuncts to diagnose diabetic neurogenic bladder and correlate with ultrasound results in determining bladder function in patients.

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Section: Introductionmentioning

confidence: 99%

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

2022

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“…Although the abnormalities on EAS-EMG can be present in other conditions such as PD [40,41], progressive supranuclear palsy (PSP) [42] and DLB [43]and its usefulness in distinguishing MSA from PD may be lower in patients with longer disease duration >5 years [36], this test remains a valuable diagnostic tool in distinguishing MSA from other parkinsonian symptoms when being used in conjunction of other investigations in patients with suspected MSA. A delay in BCR latencies has also been shown in parkinsonian disorders compared to controls, and prolonged BCR latencies were found in MSA patients compared to PD [44][45][46].…”

Section: Multiple System Atrophymentioning

confidence: 82%

Lower urinary tract dysfunction in Parkinsonian syndromes

et al. 2021

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Purpose of review:The aim of this review is to outline the clinical presentation, pathophysiology and evaluation of lower urinary tract (LUT) dysfunction in Parkinson's disease and other parkinsonian syndromes including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration.Recent findings: LUT dysfunction commonly occurs in neurological disorders, including patients with parkinsonian syndromes. The pattern of LUT dysfunction and its severity are variable, depending upon the site of lesion within the neural pathways. Parkinsonian syndromes are broadly divided into Parkinson's disease (PD) and atypical parkinsonian syndromes such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Different parkinsonian syndromes have distinct clinical features (e.g., dysautonomia, early dementia, supranuclear gaze palsy, higher corticol signs), and the pattern of LUT dysfunction and its severity can differ.Conclusions: LUT dysfunction is a common feature in patients with parkinsonian syndromes.Recognising the pattern of LUT dysfunction during the assessment of these patients can help management and possibly facilitate an earlier diagnosis.

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“…28 Lower elicitation rates and prolonged latencies of the bulbocavernosus reflex were observed in patients with MSA compared to patients with PD with early urogenital symptoms (Table 1). 33 Among other neurophysiological tests, auditory startle reflex has occasionally been used for distinguishing PSP (absent or reduced due to pathology in the reticular formation) from MSA (normal response) in small unblinded studies. 34…”

Section: Pelvic Neurophysiologymentioning

confidence: 99%

“…Lower elicitation rates and prolonged latencies of the bulbocavernosus reflex were observed in patients with MSA compared to patients with PD with early urogenital symptoms (Table 1). 33 …”

Section: Additional Tests In Patients With Parkinsonism Suggestive Of...mentioning

confidence: 99%

Laboratory‐Supported Multiple System Atrophy beyond Autonomic Function Testing and Imaging: A Systematic Review by the MoDiMSA Study Group

Stanković

Fanciulli

Kostić

et al. 2021

Movement Disord Clin Pract

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Background Neuroimaging has been used to support a diagnosis of possible multiple system atrophy (MSA). Only blood pressure changes upon standing are included in the second consensus criteria but other autonomic function tests (AFT) are also useful to diagnose widespread and progressive autonomic failure typical of MSA. Additional diagnostic tools are of interest to improve accuracy of MSA diagnosis. Objectives To assess the utility of diagnostic tools beyond brain imaging and AFT in enhancing a laboratory‐supported diagnosis of MSA to support the upcoming revision of the consensus criteria. Methods The International Parkinson and Movement Disorders Society MSA Study Group (MoDiMSA) performed a systematic review of original papers on biomarkers, sleep studies, genetic, neuroendocrine, neurophysiological, neuropsychological and other tests including olfactory testing and acute levodopa challenge test published before August 2019. Results Evaluation of history of levodopa responsiveness and olfaction is useful in patients in whom MSA‐parkinsonian subtype is suspected. Neuropsychological testing is useful to exclude dementia at time of diagnosis. Applicability of sphincter EMG is limited. When MSA‐cerebellar subtype is suspected, a screening for the common causes of adult‐onset progressive ataxia is useful, including spinocerebellar ataxias in selected patients. Diagnosing stridor and REM sleep behavior disorder is useful in both MSA subtypes. However, none of these tools are validated in large longitudinal cohorts of postmortem confirmed MSA cases. Conclusions Despite limited evidence, additional laboratory work‐up of patients with possible MSA beyond imaging and AFT should be considered to optimize the clinical diagnostic accuracy.

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The value of the bulbocavernosus reflex and pudendal nerve somatosensory evoked potentials in distinguishing between multiple system atrophy and Parkinson's disease at an early stage

Cited by 8 publications

References 33 publications

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

Lower urinary tract dysfunction in Parkinsonian syndromes

Laboratory‐Supported Multiple System Atrophy beyond Autonomic Function Testing and Imaging: A Systematic Review by the MoDiMSA Study Group

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