Lower urinary tract dysfunction in Parkinsonian syndromes

Vichayanrat, Ekawat; Hentzen, Claire; Batla, Amit; Simeoni, Sara; Iodice, Valeria; Panicker, Jalesh N.

doi:10.1007/s10072-021-05411-y

Cited by 7 publications

(3 citation statements)

References 83 publications

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“…Lesions in the spinal cord may cause DESD and incomplete bladder emptying. Sacral or infrasacral lesions result in denervation of bladder and/or sphincters with incompetent sphincter and poorly sustained/absent detrusor contractions (Vichayanrat et al, 2021). As aforementioned, DO may be correlated with the emergence of a capsaicin-sensitive C-fiber-mediated spinal micturition reflex caused by a reorganization of synaptic connections in the spinal cord (Banakhar et al, 2012).…”

Section: Spinal Cord Injurymentioning

confidence: 98%

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

2021

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Overactive bladder (OAB) is a common debilitating condition characterized by urgency symptoms with detrimental effects on the quality of life and survival. The exact etiology of OAB is still enigmatic, and none of therapeutic approaches seems curative. OAB is generally regarded as a separate syndrome, whereas in clinic, OAB symptoms could be found in numerous diseases of other non-urogenital systems, particularly nervous system. The OAB symptoms in neurological diseases are often poorly recognized and inadequately treated. This review provided a comprehensive overview of recent findings related to the neurogenic OAB symptoms. Relevant neurological diseases could be mainly divided into seven kinds as follows: multiple sclerosis and related neuroinflammatory disorders, Parkinson’s diseases, multiple system atrophy, spinal cord injury, dementia, peripheral neuropathy, and others. Concurrently, we also summarized the hypothetical reasonings and available animal models to elucidate the underlying mechanism of neurogenic OAB symptoms. This review highlighted the close association between OAB symptoms and neurological diseases and expanded the current knowledge of pathophysiological basis of OAB. This may increase the awareness of urological complaints in neurological disorders and inspire robust therapies with better outcomes.

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Section: Spinal Cord Injurymentioning

confidence: 98%

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

2021

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“…Often, storage symptoms (frequency/urgency±urge incontinence) precede voiding symptoms (reduced stream/flow, dribbling) 46 47…”

Section: Diagnosing Msamentioning

confidence: 99%

Multiple system atrophy

et al. 2023

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This is a practical guide to diagnosing and managing multiple system atrophy (MSA). We explain the newly published Movement Disorders Society Consensus Diagnostic Criteria, which include new ‘Clinically Established MSA’ and ‘Possible Prodromal MSA’ categories, hopefully reducing time to diagnosis. We then highlight the key clinical features of MSA to aid diagnosis. We include a list of MSA mimics with suggested methods of differentiation from MSA. Lastly, we discuss practical symptom management in people living with MSA, including balancing side effects, with the ultimate aim of improving quality of life.

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“…Similar to the observations in PD, constipation is a common autonomic disorder in MSA [ 11 ]. However, it has been reported that PD and MSA have different preganglionic and postganglionic fiber dysfunction in the autonomic nervous system and that dysuria in both diseases also has different symptoms even at an early stage [ 12 , 13 ]. Therefore, the differences in the symptoms of constipation may also help in the early diagnosis of these seemingly similar neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

Constipation Symptoms in Multiple System Atrophy Using Rome Criteria and Their Impact on Personalized Medicine

Mishima

Fujioka

Kawazoe

et al. 2022

JPM

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Constipation is one of the most common non-motor symptoms in multiple system atrophy (MSA); however, it has not been evaluated according to the standard diagnostic criteria for constipation in patients with MSA. We evaluated the characteristics of constipation in patients with MSA by using Rome criteria (Rome III), which has been validated and the widely used for gastrointestinal disorders. Fifty-one patients with MSA (29 female) were enrolled in the study. Based on the Rome III criteria, constipation was diagnosed in 29 patients (56.9%); irritable bowel syndrome was not detected. Thirty-seven patients (72.5%) were aware of their constipation. The most common constipation symptom was the sensation of anorectal obstruction (68.6%). Patients’ self-awareness of constipation was most strongly correlated to the sensation of incomplete evacuation (odds ratio: 7.377, 95% confidence interval: 1.402–38.817). The number of constipation-related symptoms was correlated with the total levodopa equivalent dose (p < 0.05). Rome criteria, which can detect various constipation symptoms, are useful for evaluating constipation in MSA, and these findings may greatly impact personalized medicine.

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Lower urinary tract dysfunction in Parkinsonian syndromes

Cited by 7 publications

References 83 publications

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology

Multiple system atrophy

Constipation Symptoms in Multiple System Atrophy Using Rome Criteria and Their Impact on Personalized Medicine

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