The value of C-reactive protein for postoperative monitoring of lower limb arthroplasty

Dupont, Colin; Rodenbach, J; Flachaire, E

doi:10.1016/j.annrmp.2008.01.014

Cited by 37 publications

(26 citation statements)

References 22 publications

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“…Previous studies have reported that, in uncomplicated THA, the CRP levels increase rapidly after surgery, up to a peak within 2-3 days. Thereafter, the levels fall and slowly become negative, in a range encompassing 3-4 to 6–8 weeks [17–20]. According to the literature, in our group of patients, the CRP mean serum concentrations peaked on the 3rd day after surgery, when a sharp increase was recorded (mean value 10.7 mg/dL).…”

Section: Discussionmentioning

confidence: 70%

Serum C-Reactive Protein and Procalcitonin Kinetics in Patients Undergoing Elective Total Hip Arthroplasty

Battistelli

Fortina

Carta

et al. 2014

BioMed Research International

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Background. The sensitivity and the specificity of different methods to detect periprosthetic infection have been questioned. The current study aimed to investigate the kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in patients undergoing uncomplicated elective total hip arthroplasty (THA), to provide a better interpretation of their levels in noninfectious inflammatory reaction. Methods. A total of 51 patients were included. Serum CRP and PCT concentrations were obtained before surgery, on the 1st, 3rd, and 7th postoperative days and after discharge on the 14th and 30th days and at 2 years. Results. Both markers were confirmed to increase after surgery. The serum CRP showed a marked increase on the 3rd postoperative day while the peak of serum PCT was earlier, even if much lower, on the first day. Then, they declined slowly approaching the baseline values by the second postoperative week. PCT mean values never exceed concentrations typically related to bacterial infections. Conclusions. CRP is very sensitive to inflammation. It could be the routine screening test in the follow-up of THA orthopaedic patients, but it should be complemented by PCT when there is the clinical suspicion of periprosthetic infection.

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Section: Discussionmentioning

confidence: 70%

Serum C-Reactive Protein and Procalcitonin Kinetics in Patients Undergoing Elective Total Hip Arthroplasty

Battistelli

Fortina

Carta

et al. 2014

BioMed Research International

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“…First, the variables such as procalcitonin and C-reactive protein (CRP) have been advised as quantitative monitoring indexes in patients with sepsis [14]. Studies have shown that they are helpful for early diagnosis and prognosis of patient suffering from sepsis [30][31][32][33][34]. But at our institution, preoperative routine examinations do not include such variables.…”

Section: Discussionmentioning

confidence: 98%

Preoperative CD4 Count or CD4/CD8 Ratio as a Useful Indicator for Postoperative Sepsis in HIV-Infected Patients Undergoing Abdominal Operations

Xia

Liu

Jing

et al. 2012

Journal of Surgical Research

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“…In the fi rst case, all studies included the same types of surgeries (orthopedic-12, cardiac-04, gastrointesti nal-04) ( Table 2). Although E18 considered orthopedic surgeries with and without prosthesis, the use of the same surgery type in almost all studies, and mainly of clean surgeries (16), homogenizes a relevant risk factor for surgical site infecti on, regarding the surgery's contaminati on potenti al. In the second case, similarly, most studies (15) verifi ed the CRP in the pre-and postoperati ve periods (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…As a result, many studies affi rm the prognosti c/diagnosti c value of CRP as a tool that should be used together with clinical assessment and other possible laboratory tests (16)(17)(18)(19) .…”

Section: Discussionmentioning

confidence: 99%

Revisão sistemática e metanálise sobre o valor preditivo da proteína C-reativa em infecção pós-operatória

Nunes

Lacerda

Jardim

2011

Rev. esc. enferm. USP

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Português / Inglês www.scielo.br/reeusp RESUMORevisão sistemáti ca sobre a proteína C--reati va (PCR) a fi m de identi fi car seu valor prediti vo no prognósti co/diagnósti co de infecção em pacientes cirúrgicos. As fontes de busca foram: COCHRANE, EMBASE, LILACS, MEDLINE E OVID, e referências bibliográfi cas dos estudos encontrados. Em todos os estudos a elevação dos níveis de PCR foi observada após a cirurgia e na presença de infecções pós-operatórias (PO), em oito estudos um pico de PCR entre o segundo e o terceiro PO foi relatado como aspecto normal da curva de PCR, declinando em pacientes sem complicações pós-operatórias, e elevando em pacientes com complicações. A metanálise revelou média de 85% (sensibilidade), 86% (especifi cidade), a área sob a curva SROC foi de 0,9060, e a Odds Rati o foi de 23,56. A PCR com outras intervenções clínicas apresenta alto valor no prognósti co/ diagnósti co de infecção pós-cirúrgica. DESCRITORES Proteína C-reati va Período pós-operatório Infecção da ferida operatória Revisão ABSTRACTThis systemati c review on C-reacti ve protein (CRP) was performed with the purpose to identi fy its predicti ve value in the prognosis/diagnosis of infecti on in surgical pati ents. The sources used in the search were: COCHRANE, EMBASE, LILACS, MED-LINE and OVID, and bibliographic references of the located studies. All studies found increased CRP levels aft er surgery in cases of postoperati ve infecti on (PO), in eight studies a CRP peak between the second and third PO was reported as normal aspect of the CRP curve, reducing in pati ents without postoperati ve complicati ons and increasing in pati ents with complicati ons. The meta-analysis revealed an average of 85% (sensiti vity), 86% (specifi city), the area under the SROC curve was 0.9060, and the Odds Rati o was 23.56. Along with other clinical interventi ons, CRP is considerably valuable in the prognosis/diagnosis of postoperati ve infecti ons. DESCRIPTORS C-reacti ve protein Postoperati ve period Surgical wound infecti on Review RESUMENRevisión sistemáti ca sobre la proteína Creacti va (PCR) para identi fi car su valor predicti vo en pronósti co/diagnósti co de infección en pacientes quirúrgicos. Las fuentes de búsqueda fueron: COCHRANE, EMBASE, LILACS, MEDLINE y OVID, y referencias bibliográfi cas de los estudios encontrados. En todos los estudios la elevación de los niveles de PCR fue observada después de la cirugía y en presencia de infecciones postoperatorias (PO), en 8 estudios un pico de PCR entre el 2º y el 3º PO fue defi nida como aspecto normal de la curva de PCR, declinando en pacientes sin complicaciones postoperatorias, y elevándose en pacientes con tales complicaciones. El meta-análisis determinó una media de 85% (sensibilidad), 86% (especifi cidad), el área bajo la curva SROC fue de 0,9060, y el Odds Rati o fue de 23,56. La PCR junto a otras intervenciones clínicas presenta alto valor en el pronósti co/diagnósti co de infección post quirúrgica. DESCRIPTORESProteína C-reacti va Periodo postoperatorio Infección de herida op...

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The value of C-reactive protein for postoperative monitoring of lower limb arthroplasty

Cited by 37 publications

References 22 publications

Serum C-Reactive Protein and Procalcitonin Kinetics in Patients Undergoing Elective Total Hip Arthroplasty

Serum C-Reactive Protein and Procalcitonin Kinetics in Patients Undergoing Elective Total Hip Arthroplasty

Preoperative CD4 Count or CD4/CD8 Ratio as a Useful Indicator for Postoperative Sepsis in HIV-Infected Patients Undergoing Abdominal Operations

Revisão sistemática e metanálise sobre o valor preditivo da proteína C-reativa em infecção pós-operatória

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