The Use of Rectal Misoprostol as Active Pharmacological Management of the Third Stage of Labor

Diab, Khaled; Ramy, Ahmed; Yehia, Mohamed

doi:10.1111/j.1447-0756.1999.tb01171.x

Cited by 37 publications

(24 citation statements)

References 19 publications

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“…But lead to differing and sometimes contradictory results regarding its effectiveness. [7][8][9][10][11][12] Indeed misoprostol or oxytocin doses and routes of administration were wideranging in these studies; moreover active delivery techniques were not always clearly stated or differed from one study to the other.…”

Section: Introductionmentioning

confidence: 94%

“…8 This could be due to the methylergometrine which has hypertensive properties. 9,[19][20][21] In these studies. The average volume of blood loss varied between 155 ml and 193.5 ml in patients who received misoprostol; close to the average volume of 196.5 ml observed in our study.…”

Section: Effectivenessmentioning

confidence: 99%

“…but lower than that of Kundodyiwa (3.7%). 9,19,24 It shall be noted that Bamigboye and Caliskan with 400 mcg administered rectally and El Refaey with 500 mcg per os. reported comparable effectiveness to oxytocin 10 IU IM for the prevention of severe PPH.…”

Section: Misoprostolmentioning

confidence: 99%

“…Our results are consistent with those of Bulgaho, Walley, Zachariah, Afolabi and Caliskan who orally or rectally administered doses of 400 to 500 mcg of misoprostol comparing it to oxytocin or syntometrine. 9,10,19,22 Bellad observed a greater effectiveness of 400 mcg of misoprostol via the perlingual route over 10 IU IM oxytocin. 21 The need for additional oxytocics to limit blood loss is another criterion for measuring the therapeutic effectiveness of uterotonics used as first-line treatment.…”

Section: Misoprostolmentioning

confidence: 99%

“…17,18,25 No superiority of one treatment over the other was noted in the various studies where 400/500 mcg of misoprostol per os/perlingual was compared to oxytocin and/or Syntometrine®. 9,10,19,21,23 It shall be noted that Cook. Comparing 400 mcg of orally administered misoprostol to oxytocin and/or Syntometrine®.…”

Section: Misoprostolmentioning

confidence: 99%

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Active management of third stage of labour with low doses of oral misoprostol and oxytocin on low: risk parturient in a Sub-Saharan hospital, Dakar, Sénégal

Diallo¹,

Sylla²,

Diouf³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Assess the effectiveness of oral misoprostol as an alternative to oxytocin in the active management of the third stage of labour in Dakar/Senegal.Methods: Randomized controlled clinical trial conducted in the maternity ward of a university hospital on 304 women who had vaginal delivery. These women were randomly assigned into 2 groups based on active delivery conditions: the first group received an oral administration of misoprostol (400 mcg) and the second group 5 IU oxytocin through intravenous route.Results: The average volume of blood loss was 196.55 ml in the misoprostol group and 208.39 ml in the oxytocin group (p=0.63). The incidence of postpartum haemorrhage (>500 cc) was 6.49% in the misoprostol group and 9.33% in the oxytocin group (p=0.358). The average rate of haemo globin decline was 0.38 g/dl in the misoprostol group and 0.29 g/dl in the oxytocin group (p=0.99). The proportion of hyperthermia, shivering, and nausea in the misoprostol and oxytocin groups were respectively: 2.59% against 0.6% (p=0.123), 7.14% against 2% (p=0.001) and 2.59% against 0.6% (p=0.498).Conclusions: In Senegal, Misoprostol despite its side effects, is an effective alternative to oxytocin in the active management of the third stage of labour for low-risk parturient women to reduce the risk of maternal deaths due to post-partum hemorrhage.

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